I'm an old time wheel gun fan. No safeties and a guaranteed six rounds as fast as you can pull the trigger.
I'm in favor of open carry. I don't know what the negatives would be, but I felt very safe on my horse with one strapped around my waist, in a holster, in secluded areas where I road, often.
When I first moved to Vegas more than 30 years ago, there were a couple of guys who walked around town wearing a gun belt with very large revolvers.
Nobody ever messed with them!