Cancer Cures

[badger2]

Yes and sunspots could effect the greening as well? You may actually have another Xanthoria or a Caloplaca:

Parietin
Parietin - Wikipedia

What wiki does not say is that parietin is an anthraquinone, so one may compare other structures of anthraquinones, and that parietin occurs externally on the lichen:

'Apothecia lecanorine, sessile or short stipitate; disk concave to becoming convex, yellowish orange or orange or orange reddish; hypothecium hyaline to pale brown; hymenium hyaline below, with anthraquinone crystals above; paraphyses capitate, sometimes containing oil droplets; spores 8, ellipsoidal to cylindrical, 2-celled, polariocular. Pycnidia immersed; condia short cylindrical or ellipsoid.'
(Thomson, Lichens of Wisconsin)

The parietin study, of course, used pure parietin, separated from its naturally-occurring context. Outer crystals would mean that rain could wash the parietin into a drinking basin for animals. When considering the entire lichen, one cannot be sure of the effects or anti-effects of the other constituents. It would be interesting to know abgouot the oil.

 

[badger2]

UV-B stimulates parietin synthesis. Once these wavelengths are identified, they can be compared with the wavelengths that down- or up-regulate genes in the medaka/zebrafish/platyfish cancer model, which goal is to link the wavelength to the gene.

Here are guidelines for comparison from onlinelibrary.wiley.com:
UV Induction of Sun-Screening Pigments in Lichens
'....3. Biosynthesis of the pigment must be inducible by the relevant radiation.'

 

[badger2]

Wiki does mention anthraquinones on the Xanthoria parietina page as well as Rumex crispus. However, the lichen model distributes parietin into the environment, whereas Rumex sequesters it in its roots.

 

[RodISHI]

Yes the other one is more orange-red in color. we haven't had much sun this year so maybe later the changes will occur. I will try to remember to watch and see if it does. It would take a lot of the stuff to make much oil.

On another note there is another plant that may interest you. Galium Aparine, Cleavers, sticky weed, etc. It has some good properties and asperulosidic acid. Asperulosidic acid has been found to be effective on JB6 cells. Cleavers Herb Uses, Benefits, Cures, Side Effects, Nutrients. Cleavers tinctures have an affinity for clearing lymph nodes too. Fresh its pretty juicy and I imagine it grows there too.

Yes Dock root has been used for centuries by females with hormonal issues.

 

[badger2]

Cleavers a la Euell Gibbons and there's more from the Russian side. Amounts of oil, amounts of parietin, but how to separate and condense the active constituents? What effective dose, what under- or overdose? How to direct the med to the target intact, to the lymph node?

 

[badger2]

Three anti-prion lichens are mentioned here:

Degradation of the Disease-Associated Prion Protein by a Serine Protease from Lichens
journals.plos.org/plosone/article?id=10.1371/journal.pon.0019836

 

[badger2]

We can further investigate these three lichens later. The taxol-owl-tree paradox is that the lichen requires a tree that has not been molested long enough to allow lichenization. Xanthoria is a heavy-meatl accumulator, so synthesized parietin makes sense. Nonetheless, there is no barrier to applying these compounds in an experimental protocol with the fish models of cancer.

 

[RodISHI]

Cleavers a la Euell Gibbons and there's more from the Russian side. Amounts of oil, amounts of parietin, but how to separate and condense the active constituents? What effective dose, what under- or overdose? How to direct the med to the target intact, to the lymph node?

Well if you are playing with your fish like I do you can add small amounts to their feed and check their innards out later to see if you are getting positive results or not Just don't butcher the fav one that acts like a puppy dog and gets into your hand, it'll work out.

 

[badger2]

There are fish-hawks and ospreys, though parietin physically makes contact with the talons of the owl. As far as is known, there are no published experiments with Alpinia and lichens in combination for fish melanomas.

'Melanoma is one of the most aggressive forms of cancer with still rapidly increasing incidence in the western world. Melanoma is a paradigm for the complexity of cancer. The clinical heterogeneity of the disease is astonishingly high, ranging from spontaneous total remission to extremely fast, fatal progression.'
(Schartl M, et al, Conserved Expression Signatures between Medaka and Human Pigment Cell Tumors)

 

[badger2]

No, radical fishplay: injecting parietin and Alpinia directly into the tumor of the transparent fish to see what happens.

 

[RodISHI]

The active ingredient in Alpinia ACA dissipates rapidly once drawn from a dried root so it needs to be boil and used asap. Water was the recommendation drawing agent for best results. I merely used the finely ground leftovers like a paste after making some tea on a black mole and it lighten it several shades after a couple of days.

Here is an article I had not read yet on glioblastoma 1'-Acetoxychavicol acetate promotes caspase 3‑activated glioblastoma cell death by overcoming enhanced cytokine expression ............1'‑acetoxychavicol acetate (ACA), a naturally derived antioxidant that inhibits xanthine oxidase, was evaluated for its role as an anti‑tumorigenic agent in glioblastomas. The study revealed that ACA inhibited glioblastoma cell proliferation as a consequence of promoting apoptotic cell death by enhancing caspase 3 activity. It was also shown that ACA impaired the migratory ability of glioblastoma cells by decreasing their adhesive properties. Additionally, ACA increased the protein expression levels of the pro‑survival signaling cytokines, IL‑6 and IL‑1α, established cell protectors and survival molecules in brain tumors. Together, these results demonstrate that, despite enhanced expression of compensatory signaling molecules that contribute to tumor cell survival, ACA is an effective pro‑apoptotic inducing agent in glioblastomas................

Another one on skin https://www.hindawi.com/journals/tswj/2013/186505/

 

[badger2]

The lightening effect is encouraging news, and we'll have to add the silkworm model because of it. We can see the acetoxy moiety coming through in the synthesis of taxol. A similar molecule that is coming on strong these days is docetaxel:

May 2017: Docetaxel-Loaded Nanoparticles / Triple-Negative Breast Cancer
Treating metastatic triple negative breast cancer with CD44/neuropilin dual molecular targets of multifunctional nanoparticles. - PubMed - NCBI

 

[RodISHI]

Not a whole lot of info on it but it also has skin lightening effects and has been widely used by homeopaths and herbalist for skin conditions Iris versicolour

 

[badger2]

Nice snag, Rodishi. Dr. Willy Burgdorfer enjoyed working in his Iris garden. The asperuloside you mentioned links to its biosynthesis. The precursor of asperuloside is loganine, also found in Catharanthus, so this is the chemotherapy pivot for those ingestinjg Catharanthus: hair loss.

Loganine Precursor to Asperuloside
[Loganine as precursor in the biosynthesis of asperuloside]. - PubMed - NCBI

Catharanthus
Novel bisindole derivatives of Catharanthus alkaloids with potential cytotoxic properties. - PubMed - NCBI

 

[badger2]

The 1'-Acetoxychavicol preferentially kills melanoma cells, which is paradoxical because down-regulation of adhesion signaling is shared by both the compound and the melanoma. It looks like something to load into nanoparticles for fish experiments.

 

[badger2]

We investigate another paradox, namely that between melanoma and Duchenne muscular dystrophy. The mascot plant is Valeriana officinalis. One pivotal signaling pathway for the MD-melanoma assemblage is valproic acid, which links back to Streptomyces hygroscopicus and rapamycin-mTor, and RodIshi's post on Vit. K:

Valproic Acid (VPA)
Molecular and therapeutic potential and toxicity of valproic acid. - PubMed - NCBI
'....Duchenne muscular dystrophy is a skeletal muscle degeneration disease. Possibility of using VPA was recently demonstrated in vivo and in vivo on mice, mdx/utrn -/-. VPA activates PI3K/AKT/mTor pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy (Am. J. Pathol. [2009] 174: 999-1008)....Vitamin K-dependent coagulopathy....effects correlate with DNA decondensation (in breast cancer cells)....48 hours....used as an anti-epileptic and mood stabilizer.'

 

[badger2]

A2 Dendritic Cell-Targeted Gorilla Adenoviral Vector for Cancer Vaccination for Canine Melanoma
A One Health overview, facilitating advances in comparative medicine and translational research. - PubMed - NCBI

 

[RodISHI]

I think I'll pass on the vaccine.

Another natural not widely tested but an oldie is Silphium perfoliatum. There are a lot of ins and outs on this one and its chemical properties but it is worth pursuing more testing on it as it has both anti-bacterial and anti-fungal properties. China is ahead of everyone on this one they are seeking to by it in mass. I had went out to get some out in the field last year and step into a hornets nest along the way but made sure I got some it today as it kills Gram-positive (Enterococcus faecalis., Staphylococcus aureus.) and Gram-negative (Escherichia coli., Pseudomonas aeruginosa, bacteria.). As I tried to decide whether or not to toss the leaves I looked it up. The triterpene glycosides of Silphium perfoliatum kills phytopathogenic fungi. These fungi are a major issue for some cancer patients; from blood (cancer) to skin infections.

 

[badger2]

Chinese are adept. Nevertheless, we won't be forgetting German chemistry any time soon.

Silphium was first described by Michaux, the French explorer-botanist who had a garden established at Ten Mile Station, South Carolina. We have already mentioned caryophyllene in this thread as well as the acetoxy moiety:

www. The Chemical Composition of Essential Oils and Lipophilic Extracts of Silphium integrifolium Michx. and Silphium trifoliatum L. Rhizomes
'....beta-caryophyllene....16-acetoxycarterochaetol....'

We have already mentioned proline in this thread.

May 2017 China / Silphium / Proline / Phenols
Characterization of Chinese Unifloral Honeys Based on Proline and Phenolic Content as Markers of Botanical Origin, Using Multivariate Analysis. - PubMed - NCBI

Sequestration of Lichen Compounds by Lichen-Feeding Members of the Arctiidae (Lepidoptera)
Sequestration of lichen compounds by lichen-feeding members of the Arctiidae (Lepidoptera). - PubMed - NCBI
....indicate that the larvae feed only on the algal and cortical layers of the thallus, which are vitrually free of phenolic compounds....larvae of Eilema complana collected near Stalhof (Niederoesterreich) were reared for the last five days of their larval period in the laboratory on the lichen Cladonnia pyxidata'(L.) Hoffm., containing fumaroprotocetraric acid.'

We have mentioned parietin from lichens in this thread.

Transovarial Parietin
Sequestration of lichen compounds by three species of terrestrial snails. - PubMed - NCBI
'....was transferred from the mother to the eggs in the reproductive tract.'

 

[badger2]

A valproic acid contraindication arises during gestation:

VPA / Adenomatoid Malformation
Nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation: Evidence for a new entity or consequence of g... - PubMed - NCBI
'....She took valproic acid from the beginning of the gestation, at the end of the thírd month used misoprostol....genome-wide study detected one copy number variation classified as rare, entirely contained in the SPATA5 gene....unusual nasoethmoidal meningocele in a child presenting bilateral congenital cystic adenomatoid malformation.

Germany-Brazil / Microglia / Valproic Acid
Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia. - PubMed - NCBI
'HDAC inhibitors valproic acid (VPA) and sodium butyrate (NaBut)....histone hyperacetylation....

We can now connect to other lichenoid compounds linking histone to chromatin remodeling.