Cancer Cures

[badger2]

This Korean study probes the ribosome and mitochondria relating to lichenoid compounds. The genus Catoplaca contains parietin:

Lichen Compounds / Chromatin Remodeling Inhibition
Lichen-forming fungus Caloplaca flavoruscens inhibits transcription factors and chromatin remodeling system in fungi. - PubMed - NCBI
'....Lichen extracts also have powerful antifungal and antibactieral activities, yet many lichen secondary metabolites have not been characterized, and their modes of action have not been defined....codes for gamma-glutamyl kinase, which catalyzes the first step of proline biosynthesis....

 

[badger2]

Beware Chinese capitalism. Michaux himself described American Schisandra species, though now it is extirpated or endangered in the southeastern states of the U.S., one plant holding out in a county in Kentucky, small populations on Crowley's Ridge, Arkansas, and a few in Florida. In the meantime, one can buy Chinese Schisandra plants form a nursery in Canada, if one is really that stupid. The plants are sterile, and its the berries that contain nature's race-horse medicine, Schisandra gomisins. All horses originated in the United States. Boycott Chinese arrogance, stupidity, and avarice.

 

[RodISHI]

Beware Chinese capitalism. Michaux himself described American Schisandra species, though now it is extirpated or endangered in the southeastern states of the U.S., one plant holding out in a county in Kentucky, small populations on Crowley's Ridge, Arkansas, and a few in Florida. In the meantime, one can buy Chinese Schisandra plants form a nursery in Canada, if one is really that stupid. The plants are sterile, and its the berries that contain nature's race-horse medicine, Schisandra gomisins. All horses originated in the United States. Boycott Chinese arrogance, stupidity, and avarice.

Sounds like a plant that should be propagated in areas where it likes to grow.

Int J Mol Med. 2013 Apr;31(4):888-98. doi: 10.3892/ijmm.2013.1263. Epub 2013 Jan 31.
Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4) Carbon tetrachloride, -induced hepatic and renal injury.

 

[badger2]

The anti-hepatitis B virus activities listed at Pubmed would make one think that Schisandra is a Chinese phenomenon. Note that all of the abstracts are Chinese:

schisandra[AND]hbv - PubMed - NCBI

 

[badger2]

We have mentioned valproic acid for muscular dystrophy and complications during gestation. We have compared the lichenoid compound, parietin, and its property of chromatin remodeling inhibition. Here we link this inhibition to the muscular dystrophy that affects both males and females:

SMCHD1
The Epigenetic Regulator SMCHD1 in Development and Disease. - PubMed - NCBI

For the fungal meningitis outbreak, it was prednisolone that was contaminated. Note that as with protective pigments in lichens, so too with the pigment connection to the contaminating fungus. The fungal genus, Exserohilum is distinguished precisely due to the nature of pigmentation of the hilum. We have mentioned mTOR-rapamycin in this thread.

May 2017 Muscular Dystrophy / mTOR / Prednisolone
RhoA/Rock Inhibition Improves the Beneficial Effects of Glucocorticoid Treatment in Dystrophic Muscle: Implications for Stem Cell Depletion. - PubMed - NCBI

 

[badger2]

Keyhole-Limpet hemocyanin and Mycobacterium tuberculosis BCG have both been used in melanoma therapy. We track Balea snail passing parietin (variations, physcion) from mother to eggs.

Balea High Gene Flow Independent of Geographic Distance
An RAPD (random amplified polymorphic DNA) analysis of genetic population structure of Balea biplicata (Gastropoda: Clausiliidae) in fragmented flo... - PubMed - NCBI

May 2017: China / Keyhole Limpet Hemocyanin / Cancer Vaccine
A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model. - PubMed - NCBI

Balea is Clausiliidae;

1971: ABH Blood Group
[Presence and distribution-rates of ABH-blood group specific hemagglutinins at 13 snail-species of the family Clausiliidae]. - PubMed - NCBI

We now link TWIST1/Drosophila mentioned earlier in the thread, to a member of the Clausiliidae. The ATP link will come in handy when we investigate potassium channelopathies:

Albinaria / Drosophila / ATPase8
Novel features of metazoan mtDNA revealed from sequence analysis of three mitochondrial DNA segments of the land snail Albinaria turrita (Gastropod... - PubMed - NCBI

May 2017: From Ocean to Bedside
From Ocean to Bedside: the Therapeutic Potential of Molluscan Hemocyanins. - PubMed - NCBI

 

[badger2]

Note that histone and chromatin remodeling mentioned previously link to Clausiliidae phylogeny:

Clausiliidae / Histone H3/H4
Phylogeny of the land snail family Clausiliidae (Gastropoda: Pulmonata). - PubMed - NCBI
'....the ancestor....must have colonized the New World after the Atlantic Ocean had opened.'

 

[badger2]

'Ganglioside Antigens and Vaccines

Antibody responses to human melanoma cells have prompted identification of surface antigens recognized by these antibodies. Among them are the ganglioside antigens GD2, GD3, and GM2. When GM2 is coupled to the keyhole-limpet hemocyanin protein and combined with the adjuvant QS21, this is very effective at inducing immunologlobulin G (IgG) and IgM antibodies to GM2 in humans. Because of the promising work with this vaccine approach, it has been studied in the adjuvant setting in the phase 3 randomized trial E1694. However, survival and disease-free survival were not improved over interferon-alpha-2b.'
(Cancer: Principles and Practice of Oncology, Kluwer-Lippincott, p. 1671)

 

[RodISHI]

Five reviews on people who used SCHISANDRA: User ratings for effectiveness, side effects, safety and interactions – WebMD and a lot of info if one checks the active compounds. I wonder if I can get one of those plants to grow here?

Journal Of Modern Oncology[ISSN:1672-4992/CN:61-1415/R] - Abstract
www.xdzlyx.com/en/oa/darticle.aspx?type=view&id... - Translate this page
by L Shan - ‎Related articles
Jun 3, 2014 - ... C isolated from Schizandra chinensis Baill in human leukemia U937 ... Wuweizisu C from Schisandra chinensis decreases membrane ...
PRIME PubMed | Molecular mechanisms of antiproliferative effects ...
www.unboundmedicine.com/.../Molecular_mechanisms_of_antiproliferative_effects_ind...
Apoptosis induction of human leukemia U937 cells by gomisin N, ... Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells.
synthesis antiproliferative activity: Topics by WorldWideScience.org
synthesis antiproliferative activity: Topics by WorldWideScience.org
New compounds exhibit antiproliferative activity towards leukemia and ... The indolic ring system was substituted at the C-4 to C-7 positions either by a ...... of the human leukemic cell lines K562, U937, and HL60, and the breast cancer cell ...... Further design, synthesis, and evaluation of Wuweizisu C analogs are discussed.
[PDF]Open full article - Biomedical Papers - Upol
biomed.papers.upol.cz/incpdfs/pri-990000-0200_10_026.pdf
Jul 4, 2012 - of leukemia, breast, ovarian and lung cancer, their clinical administration is ...... of mal-a in leukemic cell lines (U937, molT3, ccrF cem and K562) ...... oxyschizandrin, γ-schizandrin and wuweizisu c from seeds of Schisandra ...
schisandra sphenanthera extract: Topics by Science.gov
schisandra sphenanthera extract: Topics by Science.gov
Both WZ and NAC prevented APAP-induced c-Jun N-terminal protein kinase ...... of MAE and SE mainly contained aromatics such as schizandrins, wuweizisu C, ...... the mechanisms associated with these effects in human leukemia U937 cells

 

[badger2]

Awesome, RodIshi! It may be possible, because the northernmost specimen seems to have been the one plant in Kentucky. You would, of course, want to propagate Bay Star Vine all the way to finished seeds, which should produce more plants. Obviously, these compounds go into the Medaka-Zebrafish-Platyfish Experiments file. With an aquarium system, you could boast of "within-minutes" experiments from living plant to living fish.

 

[badger2]

Rodishi has already mentioned Gallium in this thread. Separating gallic acid from the rest of the constituents, this report will link to basal cell carcinoma as we will show:

Gallic Acid
Effects of gallic acid on delta - aminolevulinic dehydratase activity and in the biochemical, histological and oxidative stress parameters in the l... - PubMed - NCBI

 

[badger2]

Schisandra glabra
florida.plantatlas.usf.edu/Plant.aspx?id=2640

 

[badger2]

In post #191, Rodishi mentioned the acetoxychavicol study for glioblastoma. Here we link it to Schisandra, to struggle with the translation later:

Schisandraceae....Nach neuesten Befunden (Okely-Grundon 1971) handelt es sich beim Anisoxid allerdings um ein pyrogen gebildetes Artefakt; im Oel liegen genuin Dimethylallylaether des Anols ( = p-Propenylphenol) und des Chavicols (= p-Ayllylphenol) vor; aus ersterem entsteht bei hohen Temperaturen Anisoxid.
....
Schisandra: Fruechte und Wurzeln werden in Japan, China und Ruissland ebenfalls medizinisch verwendet (vor allem als Tonicum). Das aetherische Oel der Fruechte enthaelt Ylangen, Sesquicaren, alpha- und beta-Chamigren und Chamigrenal.'
(Hegenaeur, Chemotaxonomie der Pflantzen)

 

[badger2]

Deep Evolutionary Origin of Hepatitis B Virus
Possible origins and evolution of the hepatitis B virus (HBV). - PubMed - NCBI

Gorilla Adenovirus
A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla). - PubMed - NCBI

Deliberate self-medication with Vernonia is documented in chimpanzees. Here we link it to the tricyclic sesquiterpenes of Silphium, a plant already mentioned in this thread along with the daucanes. There is also a link to Joe-Pye the Massasoit in the use of Eupatorium (anti-malarial):

'Compositae. Silphinnene, Silphiperfoline, Presilphiperfolane....Silphiperfol-6-en abgeleitet sein. Ein weiteres anormal gebautes Sesquiterpen ist das Pardalianchol aus Doronicum pardalianches. Stevia serrata und S.rhombifolia lieferten Rastevion. Ausser dembereits erwaehnten Fastigiolid sind bei Compositen weitere Daucan- und Isodaucanderivate nachgewiessen worden. Dise fuer die Umbelliferin charakteristischen Sesquiterpen wurden fuer Vertreter der Eupatorieae (Ageratum fastigiatum, Chromolaena laevigata), Heliantheae (Blainvillea acmella, Calea prunifolia, Lasianthaea [=Zexmenia] fruticosa), Inuleae (Inula crithmoides) und Vernonieae (Vernonia galpinii nachgewiessen.'
(Hegemauer, op cit)

 

[badger2]

Here we link estrogen to the seeds of pokeweed, which contain ribosome-inactivating proteins (RIPs):

Progesterone
https://n.wikipedia.org/wiki/Progesterone
'....Progesterone is anti-mitogenic in endometrial epithelial cells, and as such, mitigates the tropic effects of estrogen.'

We retrieve an article from 1958 to compare tropisms:

'....1.) factors operating at the enzyme level, which affect the amount of pigment within the cell, and 2.) factos operating at a higher level of organization, which affect (movement and distribution pattern [italics]) of melanin granules within the cell. population density of of melanocytes is regulated by factors which control embryonic development and will not be discussed here....Progesterone causes dispersion of melanin granules in frog melanocytes.'
(Lerner and Case, Pigment Cell Regulatory Factors, Presented at the Brook Lodge Invitational Symposium on the Psoralens, sponsored by the Upjohn Company, Kalamazoo, Michigan, March 27-28, 1958)

 

[badger2]

Psoralens link to ribosome inactivation:

'Photopheresis is a process by which peripheral blood is exposed in an extracorporeal flow system to photoactivated 8-methoxypsoralen (8-MOP) for the treatment of disorders caused by aberrant T-lymphocytes. Photopheresis is an effective therapy for cutaneous T-cell lymphoma and for other autoimmune disorders such as pemphigus vulgaris and scleroderma. Clinical trials are in progress for treatment of multiple sclerosis, organ transplant rejection, rheumatoid arthritis and AIDS.....Table 9.1 Effects of Furocoumarins on Cells: cytoplasm: photoreactions with proteins, inactivation of enzymes, inactivation of ribosomes, etc.....'
(The Molecular Basis of Psoralen Photochemotherapy, in Organic Photochemistry and Photobiology, 1995)

 

[badger2]

'While typically thought of as a 'vitamin', it may be more appropriate to regard the primary circulating form, 25-hydroxyvitamin D (25OHD), as a pre-hormone and the primary active form, 1,25-dihydroxyvitamin D (1,25-(OH)2D), as a (hormone [italics]).....Few studies to date have analysed the associations between VDR or vitamin D pathway genetic variants and cancer outcomes, and no meta-analyses have been published to date. A review by Kosner et al (2009) concluded that associations between VDR polymorphisms and cancer prognosis are strongest for prostate cancer (rs2228570), breast (rs1544410, rs731236), malignant melanoma (rs1544410), and renal cell carcinoma (rs731236) but did not perform meta-analysis on these data.'
Vaughn-Shaw PG, et al, The Impact of Vitamin D Pathway Genetic Variation and Circulating 25-hydroxyvitamin D on Cancer Outcome: Systematic Review and Meta-Analysis)

 

[American88]

Is there a way to avoid prostate cancer?

 

[badger2]

The chemistry of saw palmetto berries link to prostate.

 

[badger2]

Lichens in Space: Aspicilia and Cosmic Radiation
Whole lichen thalli survive exposure to space conditions: results of Lithopanspermia experiment with Aspicilia fruticulosa. - PubMed - NCBI
'....was capable of repairing all space-induced damage.'

Aspicilia Cinder Lichen Photos
www.wisconsinmushrooms.com/AspiciliaCinerea

Anti-prion depsides and depsidones compare Aspicilia caesiocinerea from the southern Black Forest which contain beta-orcinol depsidones.