Cancer Cures

[danielpalos]

Marijuana helps cure some cancers. Bay leaf consumption is also, said to help with some cancers, and flavor food.

 

[badger2]

For cannabinoids, one might consider lipid head groups for cancer comparisons, though the cyanide in the smoke is the same cyanide in tobacco smoke.

 

[danielpalos]

More recently, scientists reported that THC and other cannabinoids such as CBD slow growth and/or cause death in certain types of cancer cells growing in lab dishes. Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer.--https://www.cancer.org/treatment/treatments-and-side-effects/complementary-and-alternative-medicine/marijuana-and-cancer.html

 

[jpowell123]

In one of my classes during med school we had saw a video that explains the potential of vitamin treatments for cancer. The point was to see if it could be treatable using a more natural method of curing such as vitamins. There are published papers that demonstrate the anti-cancer effects of certain vitamins, however, the problem is that the concentration needed for the vitamins to reach a therapeutic level is quite high and the effects on the body could be dangerous. Investigations are being conducted to see if this is a viable treatment. Although it is still on the fence, there are many doctors that believe very strongly about it.

 

[badger2]

Aspicilin/Squaric Acid Trajectory

This trajectory compares the two substances. For squaric acid, there is a wavelength. Squaric acid is 3,4-Dihydroxy-3-cyclobutene-1,2-dione:

Squaric Wavelength 308nm
Vitiliginous lesions induced by amyl nitrite exposure. - PubMed - NCBI

We have mentioned prednisolone in this thread.

Squaric / Alopecia / Methylprednisolone
Review of treatment for alopecia totalis and alopecia universalis. - PubMed - NCBI

May 2017 JAMA: Immunotherapy of Recurrent Herpes Labialis with Squaric Acid
Immunotherapy of Recurrent Herpes Labialis With Squaric Acid. - PubMed - NCBI

'Macrolide Constructions: Aspicilin Synthesis. Perhaps the most impressive applications of dienone photocleavage reactions have been in the area of macrolide construction.The essence of photolactonization is shown in the conversion of the 6-acetoxy-2,4-cyclohexedienone 38 to diene ketene 39. This process has been studied in great detail. A specific application, the total synthesis of the lichen macrolide (+)-aspicilin....The final transformations set the stage for hydroxylation of the C6-C5 double bond with OsO4 , to give (+)-aspicilin in 40% yield.'
(Organic Photochemistry and Photobiology, Ch. 58 Photorearrangement Reactions of Linearly Conjugated Cyclohexadienones)

We next compare Mycobacterium ulcerans, causal agent of Buruli ulcer.

 

[badger2]

Yes, antioxidant activity, but then, uveal melanoma cells contain vitamin E, likely as a strategy to protect their cells against oxidation and reactive oxygen species. One should look for studies that trace cancer types and apoptosis induction by cannabinoids.

 

[badger2]

Linking the lichen macrolide to Mycobacterium ulcerans:

Mycobacterium ulcerans / Macrolide Exotoxin
The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR. - PubMed - NCBI

 

[badger2]

May 2017 Brazil: Prohibitin / Melanoma
Accumulation of prohibitin is a common cellular response to different stressing stimuli and protects melanoma cells from ER stress and chemotherapy... - PubMed - NCBI

May 2017 Japan: Prohibitin / Breast Cancer
Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics. - PubMed - NCBI
'....Its intracellular localization without the membrane-permeable polyarginine sequence was possible via the formation of a stable alpha-helix structure by stapling.'

 

[badger2]

2017 Spain: Cutting Edge Anti-Cancer

'The mechanisms whereby some tumor cells detach from the primary lesion to colonize distant sites are still largely unknown.....When cell lines and patient-derived cells (PDCs) arising from human oral carcinomas were pulsed with a lipophilic fluorescent dye that non-specifically binds to membranes and is diluted upon cell division, and were orthoptically injected into the oral cavity of NOD.Cg-Prkdc(scid)Il2rg(tm1Wjl/Szj (NSG) mice, we observed a small percentage of slow-cycling CD44(bright)/dye+ long-term label-retaining cells (LRCs) within oral lesions....Gene ontology analysis indicated that the CD44(bright) dye(-) signature was associated with chromosomal instability, cell transformation and neoplasm and genes involved in the cell cycle, as expected from a proliferative tumor population.

On the other hand, the signature LRCs included an over-representation of genes associated with lymphatic metastasis, neoplasm metastasis, response to lipids and lipid metabolic process.....Notably, 69 genes were found in the dye+ signatures from both the SCC-25 and the Detroit-562 cell lines.

CD36 Is Essential for Metastasis
Overexpression of CD36 in cell lines or PDCs with low metastatic potential greatly increased their potentiasl to metastasise to lymph nodes, with penetrance increasing from less than 20 to 75-80%. Lymph node metastases generated by OSCC tumors overexpressing CD36 were also more than 40 times the size of those generated by the parental cells. Most importantly, short hairpin RNA (shRNA)-mediated depletion of CD36 significantly reduced the penetrance of metastases to lymph nodes, in some cases by 80-100%. CD26 depletion greatly reduced the size of lymph node metastases in all tumor lines, and inhibited lung metastasis by FaDu cells.
(Pascual G, et al, Targeting Metastasis-Initiating Cells Through the Fatty Acid Receptor CD36, Nature [2017] 541: 41)

 

[badger2]

'The boost in metastatic potential of OSCCs in high-fat diet-fed mice correlated with an increase in the percentage of CD36+ cells in oral and metastatic lesions, suggesting that the expression of CD36 might be sensitive to the concentration of fatty acids....In addition, exposure of cultured OSCC cells to palmitic acid, a dietary fatty acid recognized by CD36, for 2 days also robustly increased the percentage of CD36+ cells. Palmitic acid increased the size and frequency of lymph node metastases in a manner dependent on CD36, without affecting primary tumor growth. Notably, palmitic acid promoted lung metastasis in 10% of mice, something we did not observe in the more than 100 mice inoculated with control SCC-25 tumor cells.

As CD36 can activate fatty acid beta-oxidation, we hypothesized that CD36 inhibition leads to accumulation of endogenously synthesized, unmetabolized lipids. This continuous lipid accumulation would ultimately result in metastatic lipotoxicity and cell death.....Notably, CD36- cells did not generate even a single lymph node metastasis, whereas CD36+ cells formed metastases with an even higher penetrance than the parent cells....More strikingly, treating mice that had already developed lymph node metastasis with daily intraperitoneal injections of JC63.1 anti-CD36 neutralizing antibodies reduced the size of lymph node metastases by 80-90%, and resulted in complete remission in 14% of mice, in a dose-dependent manner and without affecting oral lesion sizes by the endpoint.'
(Pascual, op cit)

 

[badger2]

Regarding the therapeutic significance of our findings, several lines of evidence suggest that CD36+ cells constitue a general mechanism of metastasis. Besides our results in OSCC, melanoma, luminal breast cancer, bladder cancer, and lung SCC, CD36 drives glioblastoma progression, is amplified in metastases in most types of human tumors, and promotes the motility of hepatocellular carcinoma cells. Furthermore, lipid metabolism is part of the signature that defines the most invasive cells in murine epidermal SCC and is required for metastasis of ovarian cancer cells. We further expect that targeting CD36 and CD36+ metastasis-initiating cells could provide a breakthrough therapy to specifically target the metastatic process.'
(Pascual, op cit)

 

[badger2]

We have already mentioned parietin from Xanthoria lichens and others. Names for parietin are:

1,8-Dihydroxy-6-methoxy-3-methyl-anthracene-9,10-dione

1,8-Dihydroxy-3-methoxy-6-methyl-anthraquinone

physcion(e)

rheochrysidin

methoxyemodin

Comparing the Spanish CD36 cancer metastasis report (for palmitic acid), there is

Anti-Obesity / Zebrafish Nile Red Assay / Sponge-Associated Fungus / Emodin-Rheoemodin / Palmitic Acid
A New Ergosterol Analog, a New Bis-Anthraquinone and Anti-Obesity Activity of Anthraquinones from the Marine Sponge-Associated Fungus Talaromyces s... - PubMed - NCBI

 

[RodISHI]

2017 Spain: Cutting Edge Anti-Cancer

'The mechanisms whereby some tumor cells detach from the primary lesion to colonize distant sites are still largely unknown.....When cell lines and patient-derived cells (PDCs) arising from human oral carcinomas were pulsed with a lipophilic fluorescent dye that non-specifically binds to membranes and is diluted upon cell division, and were orthoptically injected into the oral cavity of NOD.Cg-Prkdc(scid)Il2rg(tm1Wjl/Szj (NSG) mice, we observed a small percentage of slow-cycling CD44(bright)/dye+ long-term label-retaining cells (LRCs) within oral lesions....Gene ontology analysis indicated that the CD44(bright) dye(-) signature was associated with chromosomal instability, cell transformation and neoplasm and genes involved in the cell cycle, as expected from a proliferative tumor population.

On the other hand, the signature LRCs included an over-representation of genes associated with lymphatic metastasis, neoplasm metastasis, response to lipids and lipid metabolic process.....Notably, 69 genes were found in the dye+ signatures from both the SCC-25 and the Detroit-562 cell lines.

CD36 Is Essential for Metastasis
Overexpression of CD36 in cell lines or PDCs with low metastatic potential greatly increased their potentiasl to metastasise to lymph nodes, with penetrance increasing from less than 20 to 75-80%. Lymph node metastases generated by OSCC tumors overexpressing CD36 were also more than 40 times the size of those generated by the parental cells. Most importantly, short hairpin RNA (shRNA)-mediated depletion of CD36 significantly reduced the penetrance of metastases to lymph nodes, in some cases by 80-100%. CD26 depletion greatly reduced the size of lymph node metastases in all tumor lines, and inhibited lung metastasis by FaDu cells.
(Pascual G, et al, Targeting Metastasis-Initiating Cells Through the Fatty Acid Receptor CD36, Nature [2017] 541: 41)

So avoiding foods that create platelet aggregation like pork and increasing foods that help prevent platelet aggregation like spinach would be helpful for some?

 

[badger2]

There's more to it than platelet aggregation, palmitic acid and pork, though folic acid in spinach is a good preventive countermeasure:

China: CD34 Deficiency / Tryptophan Mutation
[A novel CD36 mutation T538C (Trp180Arg) results in CD36 deficiency and establishment of a genotyping method for the novel mutation based on sequen... - PubMed - NCBI

Quite a few researchers are working on this:

African American CD36 Nonsense Variant / Lipid Traits
Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. - PubMed - NCBI

 

[RodISHI]

It would be interesting to include those with the ages, consider the vaccines, and the regions of the country for the different family members too.

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. - PubMed - NCBI
Finally, through Mendelian randomization, we provide evidence of shared genetic pathways linking blood cell indices with complex pathologies, including autoimmune diseases, schizophrenia, and coronary heart disease and evidence suggesting previously reported population associations between blood cell indices and cardiovascular disease may be non-causal.

 

[badger2]

'As is well known, F.G. Hopkins in England isolated fractions rich in pigments from butterfly wings and attempted to determine their nature. In his first publication (1889) he described the yellow pigment of the brimstone butterfly. Six years later, he reported the white pigment from another Pierid, the cabbage white butterfly.

Deprivation of folic acid, either directly or through use of an antagonist, leads to death. The function of folic acid is to insert a single carbon atom wherever this is required in biosynthesis....Methotrexate, introduced into the clinic in 1958, has proved to be an excellent and reliable drug in certain forms of cancer. This substance differs from folic acid in two particulars, the oxo-function in the 4-position has been replaced by an amino-group, and the hydrogen atom in the 10-position by a methyl-group. Methotrexate, alone or in combination with other inhibitors of DNA synthesis, provides the standard treatment for the leukemia of young adults. In addition, methotrexate provides a rapid and complete cure for two other, otherwise fatal, forms of cancer: choriocarcinoma (a fast-growing tumour of pregnancy) andf Burkitt's lymphoma ( a solid tumour of the jaw affecting many children in Africa). It is also used in severe cases of psoriasis.....Unfortunately, it has little toxicity for most bacteria and protozoa, because it can no more be taken up by these organisms than folic acid can. As soon as it was seen that p-aminobenzoic acid was part of the folic acid molecule (and it does not occur elsewhere in Nature) it was realized that the sulfonamide drugs owed their antibacterial action to interference with the synthesis of folic acid.'
(Albert A., Significant Steps in the Discovery and Application of Pteridines, in Chemistry and Biology of Pteridines, Wolfgang Pfleiderer ed., de Gruyter [1975])

 

[RodISHI]

I was reading something here awhile back about iron loving and vitamin B loving blood parasites. Possible there is something smaller than what has been found thus far to be discovered yet.

 

[badger2]

Iron and CD36, and the hydrocephalus links to congenital muscular dystrophy (mulpitle genes involved):

CD36 / Iron
Simvastatin Promotes Hematoma Absorption and Reduces Hydrocephalus Following Intraventricular Hemorrhage in Part by Upregulating CD36. - PubMed - NCBI
'....higher expression of CD36 was detected around the hematoma....less iron accumulation and more cilia survival....hydrocephalus....'

In congenital MD, it is the dystrophin-glycoprotein complexes that help produce lissencephaly and hydrocephalus.

 

[badger2]

There is the CD36-Plasmopdium connection for parasite studies. CD36 also links to fungi.

CD36
CD36 - Wikipedia
'....erythrocytes parasitized with Plasmodium falciparum....interacts with FYN....'

FYN interacts with paxillin, focal adhesion kinase, Src, etc. in Orpinomyces"
Insights into the Utility of the Focal Adhesion Scaffolding Proteins in the Anaerobic Fungus Orpinomyces sp. C1A. - PubMed - NCBI

Focal adhesion, vincuilin, etc. we are in the realm of amanita toxins at the extracellular matrix.

 

[badger2]

This study links CD36 connections to cardiomyocytes:

2016 Cardiomyocyte Progenitor Cells / Vinculin / Amanita Phalloidin / FAK / Collagen IV / Permeabilization with Triton-X
Cardiomyocyte progenitor cell mechanoresponse unrevealed: strain avoidance and mechanosome development. - PubMed - NCBI