Cancer Cures

Discussion in 'Health and Lifestyle' started by Buck111, Apr 15, 2017.

  1. badger2
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    badger2 Active Member

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    Yes, though we must go back to Batrachochytrium in the webbing of Xenopus foot found in a museum in South Africa. That is how we may best address the issue of vanadium and sulfur upwellings due to El Nino on the Peruvian coast, in synch with plague outbreaks in that country. What were the parameters of forg skin before the pollution?

    'Grossman: There are scattered alpha-melanocyte-stimulating-hormone-(MSH-secreting cells in the human pituitary, but they do not seem to be related to the residual pars intermedia and they don't seem to change in any uniform manner.

    Gold: There has never been a a corroborated report alpha-MSH in human blood.

    Grossman: Early studies suggested that alpha-MSH increased during pregnancy, but these were subsequently withdrawn. One occasionally finds aplha-MSH in the blood of patients with ectopic Cushing's syndrome, but this is not a pathological finding.'
    (CIBA Foundation Symposium, 1993 pp. 30-58)
     
  2. badger2
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    badger2 Active Member

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    Well now, you've lead us right back to fish, because the Janthinobacteria link to Chromobacterium on Noprth Atlantic Cod skin, and Chromobacterium does link to breast cancer: C. violaceum.

    'Although there is little sequence homology between D(and its amidated form, E) and the bovine gamma-MSH sequence, their lack of melanotrophic activity compared with the two other dogfish peptides, alpha and berta MSH, and the poor activity of synthetic bovine MSH suggest their assignment as gamma-MSH peptides. It is interesting to note there that the unconservative substitutions in the core sequence of dogfish beta-MSH compared with bovine beta-MSH (Phe for Met and Gly for Glu) have maintained its potent MSH activity whilst both gamma-MSHs which have a more recognizable core sequence (Met-X-His-Phe-Arg-Trp) are comparatively inactive as melanotrophic peptides.
    (Natural Occurence but Lack of Melanotrophic Activity og Gamma-MSH in Fish, Nature [1981] 290:341)
     
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  3. badger2
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    badger2 Active Member

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    Janthinobacterium lividum used to be called Chromobacterium lividum, and C. violaceum was found on the skin of cod in 1931 in the North Atlantic. Violacein is the active constituent used for breast cancer.
     
  4. badger2
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    badger2 Active Member

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  5. badger2
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    badger2 Active Member

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    UVC in California

    'Intensity of UV radiation was measured with a UVX digital radiometer. Because UVC radiation was detected and intensity of UVB was too high based on preliminary experiments, UV light was filtered out through a sheet of Mylar-polyester. Fish in control group were exposed to fluorescent light.'
    (Ramirez-Duarte WF, et al, Effects of Low Levels of Ultraviolet Radiation on Antioxidant Mechanisms of Japanese Medaka (Oryzias latipes), Chromosphere 2017 181: 304)
     
  6. badger2
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    Into Africa

    We're going in at the mangroves of South Africa to make the melanoma connection:

    South African Mangroves / Diplodia
    Endophytic Botryosphaeriaceae, including five new species, associated with mangrove trees in South Africa. - PubMed - NCBI

    Once again, changing names is always a job-security option, anbd we have aqlready mentioned the valine in the V600E / BRAF mutation in this thread: Diplodia is Sphaeropsis.

    Sphaeropsidin A / Melanoma
    Computed determination of the in vitro optimal chemocombinations of sphaeropsidin A with chemotherapeutic agents to combat melanomas. - PubMed - NCBI
    '....forces melanoma cells to undergo apoptosis regardless of the genetic BRAF and NRAS status.'
     
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  7. RodISHI
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    RodISHI Gold Member

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    Did it morph all on its own or did it have some help?
    Phylogeny and pathogenicity of Lasiodiplodia species associated with dieback of mango in Peru
    Individual and combined gene genealogies suggest that this Lasiodiplodia sp. is possibly a hybrid of Lasiodiplodia citricola and Lasiodiplodia parva. Apart from Lasiodiplodia theobromae, which was the most prevalent species, all other species are newly reported from Peru. Moreover, L. iraniensis is reported for the first time on mango. Inoculation trials of mango plants confirmed Koch's postulates, and revealed differences in aggressiveness among species and isolates.
     
  8. badger2
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    badger2 Active Member

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    Taxol, continued

    'A titanium-mediated pinacol coupling, also known as the McMurry coupling reaction, appeared particularly attractive. It is important at this point to acknowledge important precedent that encouraged the selection of this particular cyclization reaction. In 1986, Kende and his collaborators disclosed a convergent synthesis of a rather advanced tricyclic taxane triene via a strategy that features a McMurry coupling reaction. Although the yield for the crucial cyclization step was modest (23%), it was encouraging that the congested taxane carbon framework could be assembled through direct closure of the eight-membered B-ring.'
    (Nicolaou, Classics, op cit)

    Pinacol is 2,3-dimethylbutane-2,3-diol.

    We compare moities in the synthesis of anti-cancer agents:

    Butane-2,3-diol Moiety / Ruthenium II - Vanadium IV / Melanoma
    Preliminary anti-cancer photodynamic therapeutic in vitro studies with mixed-metal binuclear ruthenium(II)-vanadium(IV) complexes. - PubMed - NCBI
     
  9. badger2
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    Nice connection, RodIshi!
     
  10. badger2
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    A certain Dr. Taylor went into the ghettos of London to ask of Africans what folk remedy was used for tuberculosis, coming upon the constituents from Pelargonia (a Geranium). The doctor was black-balled by the establishment. Nevertheless, decades later Taylor was exonerated when it was discovered that pelargonidin is a planar molecule that can penetrate the membrane of Mycobacterium tuberculosis, the thickest biological membrane known.
     
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