Cancer Cures

[badger2]

www. "First Report of Tip Blight of Pinus tabulaeformis Caused by Sphaeropsis sapinea in China"

 

[badger2]

Hebei Province is at approx. 39 degrees 18 ' N latitude. That would link to just south of Denver, bringing up the possibility of industrial pollution as a factor besides the UV. That is the factor thought to have caused prions (CWD) in deer, and they were (eating pine needles[italics])!

www.mapsofworld.com/usa/states/colorado/lat-long.html

 

[badger2]

For the story of Tennessee "mouse ear," the active constituent is likely alpha-hairpinin, unique to Stellaria media:

2014 Russia: Stellaria media / Alpha-Hairpinin
Novel antifungal α-hairpinin peptide from Stellaria media seeds: structure, biosynthesis, gene structure and evolution. - PubMed - NCBI

A melanoma-susceptible horse is the Camargue:

Camargue Horse
Camargue horse - Wikipedia

 

[badger2]

Coral Ecology 2017: Are There Any Left?

The caryophyllene connection to Tennessee "mouse ear" is beta-caryophyllene from Stellaria species. But for breaqst cancer, there are other caryophyllenes:

Breast Cancer / Cespitularia stonlonifera / Caryophyllene Moiety
Soft coral Cespitularia stolonifera: New cytotoxic ceramides and gastroprotective activity. - PubMed - NCBI

 

[RodISHI]

Hebei Province is at approx. 39 degrees 18 ' N latitude. That would link to just south of Denver, bringing up the possibility of industrial pollution as a factor besides the UV. That is the factor thought to have caused prions (CWD) in deer, and they were (eating pine needles[italics])!

www.mapsofworld.com/usa/states/colorado/lat-long.html

Know that is an interesting connection as my big baby dog got sick after eating from a dead deer out in the field. I have often wondered if there was some connection in that for the fungal portions of the skin infections we were always battling that he had. You can see his nose has a pink to it and beyond his nose there is a dark skin area that was white before he got sick. This photo he was about six years old, that skin change started at about 1 year after he ate from the deer. He lived to be 11 but his predecessor a Chow lived to be 17 (he was diagnose with Thyroid issues two years after coming to Iowa) and his sister lived to be 14 with us but we did not have her for the first 3 years of her life; she was diagnosed with cancer three years after arriving in Iowa at 8 years old (they didn't think she would live beyond six months after the cancer was surgically removed from her throat- she fooled them- we fed her cimetidine every day after the surgery with her meals- the Chow dogs mostly ate whatever we ate and also had dog food available if they wanted it). My big baby ate almost all people food (veggies a lb of meat and generally oatmeal for main meal ea. day) and rarely had any dog food after he got sick, it was the only way to keep half ass healthy.

 

[badger2]

The dog is white like a Camargue. Would there be a link to mc1r phenotypes?

 

[badger2]

We next get ready for an important entry because it more strongly links the Australian aboriginal tree Codonocarpus to the mc1r gene and receptor. This is the gene that Sloan-Kettering, et al that links to New Mexico Hispanics for melanoma prevention testing. We now translate post #45 where is mentioned three prominent amino acids for Codonocarpus family: valine, isoleucine, and leucine. It says, 'Valin, Isoleucin, Leucin) a dissipation that should correspond to the original state of the glucosinolates characteristic.'

 

[RodISHI]

The dog is white like a Camargue. Would there be a link to mc1r phenotypes?

He was Pyrenees, that is about all I can tell you. This one's lineage was half from a local goat farmer. I have noticed with all the pups from there that they have two different shapes and features. One has a more defined face and those pups generally are extra large (200lbs this one) with more white & less spots of red generally and the other ones generally have a rounder face with more colors in their hair until they grow out of that (most turn white as adults even when they have red and light brown on them).

Canine Morphology: Hunting for Genes and Tracking Mutations

Genetics of Cream Coat Color in Dogs | Journal of Heredity | Oxford Academic

The female Chow that had the throat cancer was a light red color- consider a blonde very rare and we also got white pups with the male and another female which is exceedingly rare with Chows.

 

[badger2]

'Pigmentation variants with Mc1r alleles conferring a dark hair coat have been described in numerous mammals including cow, sheep, pig, fox, dog, and rock pocket mouse. The melanic form of jaguar, the black panther, has been shown to be due to a gain of function mutation in Mc1r.
....
In humans, residues substituted in specific Mc1r variants clearly associated with red hair and fair skin (strong "red hair color" RHC alleles R: D84E, R 142H, R151C, I155T, R160W, D294H).'
(Selz Y, et al, Evolution of Melanocortin Receptors in Teleost Fish: The Melanocortin Type 1 Receptor)

Camargue horese originate in southern France.

 

[RodISHI]

'Pigmentation variants with Mc1r alleles conferring a dark hair coat have been described in numerous mammals including cow, sheep, pig, fox, dog, and rock pocket mouse. The melanic form of jaguar, the black panther, has been shown to be due to a gain of function mutation in Mc1r.
....
In humans, residues substituted in specific Mc1r variants clearly associated with red hair and fair skin (strong "red hair color" RHC alleles R: D84E, R 142H, R151C, I155T, R160W, D294H).'
(Selz Y, et al, Evolution of Melanocortin Receptors in Teleost Fish: The Melanocortin Type 1 Receptor)

Camargue horese originate in southern France.

The Chows have all black (bluish colored) mouths inside generally and the Pyre's partially- Pyre's are also of French origin.

 

[badger2]

Recalling the valine mutations in Alzheimer's we can see that the dog is expressing the weakness of the RHC allele. In making the Codonocarpus connection to the three amino acids of the aboriginal tree, Selz Y, et al, further state that....

'Positions modified in weak RHC alleles (r) poorly associated with red hair and fair skin, such as V60L, V92M, and R163Q, are conserved or conservatively substituted in vertebrate Mc1rs. The valine residue conservatively affected in the V60L variant is also conservatively substituted but to an isoleucine in teleosts (XmaI64 [Xiphophorus]), with the exception of zebrafish (V65). At the position modified in Hsa V92M, the valine residue is conserved in teleosts but is conservatively substituted by a leucine in chicken. A natural Mc1r variant Hsa V92L is also known in human.'

Codonocarpus is expressing the same amino acids phenomenon.

 

[badger2]

The glucosinolates linking Codonocarpus link coloring in Peruvian Maca:

Maca (Brassicaceae) / Glucosinolates / Color
Influence of colour type and previous cultivation on secondary metabolites in hypocotyls and leaves of maca (Lepidium meyenii Walpers). - PubMed - NCBI

 

[badger2]

Sphaeropsidin A mechanism seems to be ion channel modulation:

Sphaeropsidin A / Drug-Resistant Cancers
Sphaeropsidin A shows promising activity against drug-resistant cancer cells by targeting regulatory volume increase. - PubMed - NCBI
'....did not match that of any other agent in the 765,000 compound database.'

 

[badger2]

Yes, ocular melanoma may now link to ocular tuberculosis mentioned previously due to sphaeropsidin's mechanism.This can also be seen in neuroblastoma and Parkinson's:

Mycobacterium / P2X7 Ion Channel Receptor / Lower Lung Bacteria / Attenuated Pneumonia
P2X7 Receptor in Bone Marrow-Derived Cells Aggravates Tuberculosis Caused by Hypervirulent Mycobacterium bovis. - PubMed - NCBI

Neuroblastoma / Parkinson's / P2X7
P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells. - PubMed - NCBI

 

[badger2]

As a promising model for both melanoma and kidney cancer, we can see where the fungus Sphaeropsis got its experience. The map in post #132 clearly shows its history along the Nile.

 

[badger2]

We'll be further examining Niole tilapia Mc1r sequence alignments, tentatively implicating a threonine with which to compare the valine/leucine/isoleucine of Codonocarpus. Sphaeropsis fungus links to Aedes aegypti:

Sphaeropsidin B / Aedes aegypti
Cyclopaldic acid, seiridin, and sphaeropsidin A as fungal phytotoxins, and larvicidal and biting deterrents against Aedes aegypti (Diptera: Culicid... - PubMed - NCBI

Cyclohexene Epoxide / Sphaeropsidin A
Effect of fungal and plant metabolites on broomrapes (Orobanche and Phelipanche spp.) seed germination and radicle growth. - PubMed - NCBI
'....strongly inhibited by sphaeropsidin A and compounds belonging to cyclohexene epoxide and cytochalasan classes.'

Breast Cancer / Vinyl Cyclohexene Diepoxide
Effects of raloxifene against letrozole-induced bone loss in chemically-induced model of menopause in mice. - PubMed - NCBI

'Of the two cyclohexenoid sectors of taxol, C-ring intermediate 10 is clearly the more complex. The chcylhexene ring in 10 includes four contiguous asymmetric carbon atoms, one of which is quaternary. When confronted with a highly sterodefined six-membered ring, one should be mindful of opportunities afforded by the powerful Diels-Alder reaction. Indeed, an important virtue of the Diels-Alder reaction is that it can create, in a single stereospecific step, a cyclohexene ring containing up to four contiguous sterogenic centers.'
(Nicolaou, Classics in Total Synthesis)

 

[badger2]

In the Mc1r sequence alignments for platyfish, medaka, tilapia, tetraodon, fugu, zebrafish, chicken, mouse, and human, there is a column showing all isoleucines, except for a threonine for the medaka. Another completely isoleucine column shows a phenylalanine exception for chicken, mouse, and human. A third completely isoleucine column shows a leucine exception for mouse, and a threonine exception for human. We thus for comparisoin add threonine to the Codonocarpus assemblage.

 

[badger2]

A Pubmed search 'isoleucine[AND]mc1r' yielded one reference:

Isoleucine / Mc1r / Owl
Effect of the MC1R gene on sexual dimorphism in melanin-based colorations. - PubMed - NCBI
'We found that valine-to-isoleucine substitution explains up to 30% of the variation in the three melanin-based color traits.'

Indeed, there is a completely valine column except for mouse and human, which are both isoleucine.

 

[American88]

The medicinal properties of that plant are truly remarkable.

I agree!!

 

[badger2]

We have traversed the pokeweed trajectory, linking it to the Australian Aboriginal tree Codonocarpus. The glucosinolate signature of Codonocarpus (valine, leucine, isolecucine) we have superimposed over the protein sequence alignments for the Mc1r gene which, as far as is known, has not yet been compared. Pokeweed (Phytolaccaceae) contains ribosome-inactivating proteins, and a riboswitch seminar is to be held in the capital of Wisconsin this coming Friday. This places the Phytolaccaceae family on the cutting edge of the anti-cancer frontier. The art now being displayed at UW cannot be downloaded to this list, though stunning is the correspondence of the artists's work "Blue Tree" to the pokeweed-Codonocarpus trajectory.