Cancer Cures

[badger2]

It is interesting to link German chemistry to azisevoflurane, that locates the binding precisely at Charlie Gard's potassium channel which resonates nicely with Jacques Monod's Internal French Forces. In addition, there uis even Russian resonance, and we will be considering more closely valinomycin-induced permeability as it relates to anaesthesia and potassium channels:

' Gradient coupling in bacteria, if it exists, may perhaps be linked to the transport of hydrogen ions. Pavlasova and Harold (1969) measured the flow of hydrogen ions into cells treated with EDTA and valinomycin, an antibiotic which makes cells more permeable to potassium.'
(The Lac Operon, op cit)

 

[badger2]

We have now established historical links for further investigation of anaesthesia, potassium channels, and their effects on the genes of MDS. Charlie Gard's first MRI was apparently performed on 7 Oct 2016, dates that link both Anna Politkovskaya and Vladimir Putin.

 

[badger2]

The dat after the Charlie Gard Foundation is established, lo and behold another connection to Aboriginals using their tree, Codonocarpus, against tongue cancer. The link is to Charlie Gard's RRM2B gene and the other 16 for the syndrome, and also meshes with what we have posted for the Lac operon:

RRM2B / Lactic Acidosis / Bilateral Neurosensory Deafness
Novel RRM2B Mutation and Severe Mitochondrial DNA Depletion: Report of 2 Cases and Review of the Literature. - PubMed - NCBI
'....All 16 presented with myopathy and lactic acidosis....novel mutation....A 2.5-month-old-boy....was the first child of consanguineous parents(first cousins) of Arab Muslim origin. The extended family has a marked pattern of consanguineous marriage.....ionized calcium (0.89 mmol/L), hypocalcemia (6.3 mg/dl)....molecular test showed normal function of mitochondrial respiratory complexes II-IV in cutaneous fibroblast culture.
....
The brother....elevated lactate level (60-120 mg/dl), elevated levels of branched-chain amino acids, valine, isoleucine, leucine and elevated alanine....massive excretion of lactate and ketones....brainstem evoked response audiometry test revealed severe bilateral neurosensory deafness.'

 

[badger2]

Following the lactic acidosis trajectory, we link it to anesthesia:

Alteration in mitochondrial membrane permeability to compounds such as alpha glycerophosphate would also influence extramitochondrial concentration of NAD because of the relationship of such compounds to shuttle systems responsible for transport of NADH across mitochondrial membranes. Resultant changes in cytoplasmic NAD concentrations could impair extramitochondrial metabolic processes such as lactate metabolism.

The in vitro findings of Fink and Kenny are supported by the in vivo data obtained by Schweizer and her associates. These investigators studied 50 patients during ether anesthesia and 50 patients during halothane anesthesia. They found blood levels of lactate and pyruvate were consistently higher following ether than following halothane anesthesia the lactateyruvate ratio also being higher with ether.....Cohen and Marshall studied the effect of halothane on the rate of uptake of oxygen in the presence of exogenously added adenosine diphosphate (ADP). They found that clinically effective concentrations of halothane produced a dose-related, reversible depression of the respiratory chain within mitochondria, and loss of mitochondria respiratory control.'
(Greene NM, Metabolic Effects of Anesthetics, in Modern Inhalation Anesthetics, Springer-Verlag Berlin, Heidelberg, New York, 1972)

 

[badger2]

For the Charlie Gard study of single-payer pathologies, we document that not all of the funding entities are named:

New York Times 3 Aug 2017 Scientists Repair Risky Mutation in Human Embryo
'....Congress has barred the Food and Drug Administration from considering clinical trials involving germline engineering. And the National Institute of Health is prohibited from funding gene-editing research in human embryos. (The new study was funded by Oregon Health and Science University, the Institute for Basic Science in South Korea, and several foundations.)'

Thus the Charlie Gard Foundation is transparent, while gene-editing support is not.

 

[badger2]

Post #453 mentioned gene-editing for the British cardiomyopathy study. We link that and muscular dystrophy from post #196 to this MD study:

Duchenne MD
Elevated Myocardial Extracellular Volume Fraction in Duchenne Muscular Dystrophy. - PubMed - NCBI

 

[badger2]

The Duchenne study (above) establishes some extracellular parameters for sodium-potassium comparisons on the Charlie Gard, et al RRM2B trajectory. It states: 'The study was approved by the Institutional Review Board at Cincinnati Children's Hospital.'

For CMR, we note the parameters for children's examinations:

Cardiac Magnetic Resonance Imaging
Cardiac magnetic resonance imaging - Wikipedia
(Scroll down to Children and Congenital Heart Disease)
'If the child cannot cooperate sufficiently, sedation with intravenous medications or general anesthesia may be necessary. In very young babies, it may be possible to perform the examination while they are in a natural sleep. New image capture techniques such as 4D flow require a shorter scan and can lead to reduced needs for sedation.'

 

[badger2]

Post # 464 should read 'lactateyruvate.'

 

[badger2]

Hirano, et al
Administration of deoxyribonucleosides or inhibition of their catabolism as a pharmacological approach for mitochondrial DNA depletion syndrome. - PubMed - NCBI
'....We propose increased cellular availability of deficient dNTP precursor by direct administration of the dN or inhibition of its catabolism.'

We have already linked Charlie Gard's potassium channel leucine317 to the Aboriginal tree Codonocarpus and the RRM2B mutation in the Arab Muslim brothers. Both the tree and the brothers show the branched-chain amino acids clue.

For Hirano et al's concept of catabolism, we again invoke the lac operon, this time including Salmonella typhimurium:

'....GD-1 strain. In all cases, the sensitivity to catabolite repression was absent. The strain grew as well upon a medium containing glucose as upon a medium containing citrate as the sole carbon source. This was confirmed by the lack of any significant difference in the specific activities of the beta-isopropylmalate dehydrogenase found for cultures grown on the two different carbon sources.
....
It thus appears that the leucine biosynthetic enzymes have come under catabolite repressor control. Indeed, the order of intensity of the repression manifested by the various carbohydrates is identical for the leucine pathway enzymes and for the normally catabolic repressor-sensitive enzyme, histidase.'
(Friedman SB, Margolin P, Cold Spring Harbor, New York, Evidence for an Altered Operator Specificity: Catabolite Repression Control of the Leucine Operon in Salmonella typhimurium, J. Bacteriol. (1968) 95: 2263-2269)

 

[badger2]

It was azirine chemistry that would go on to show precisely where the anesthetic bound in Charlie Gard's body, if indeed Charlie Gard received anesthetics, and if that anesthetic was sevoflurane. Since the name Gard links to Pence DNA buried at Rector-Gard cemetery in Ohio, we should point out that Mueller DNA links not only to azirine chemistry and the Trump news, it also links to the lac operon which by default links to salvage pathways and catabolism in Charlie Gard et al's MDS.

'Mueller-Hill B (1966) Suppressible Regulatory Constitutive Mutants of the Lactose System of Escherichia coli, J. Molecular Biology 15: 374.'
(The Lac Operon, p.217)

 

[badger2]

Linking beta-isopropylmalate dehydrogenase of Salmonella (above) to Charlie Gard's Leucine317 vital helix already mentioned in this thread, regardless of whether or not Charlie Gard received sevoflurane anesthesia:

'A series of 4 more BCAA (branched chain amino acids) enzymes, isopropylmalate synthetase, isopropylmalate isomerase, isopropylmalate dehydrogenase and aminotransferase, are necessary for the formation of leucine from 2-oxoisovalerate.'
(Biosynthesis of Branched-Chain Amino Acids: From Test Tube to Field, The Plant Cell 7: 935)

 

[badger2]

Sevoflurane anesthesia binds precisely to the leucine317 vital helix. Degradation of BCAAs involve the branched-chain alpha-keto acid dehydrogenase complex (BCKDH). A deficiency of this complex leads to buildup of leucine, valine and isoleucine qand their toxic by-products in blood and urine as can be seen in the Arab Muslim borthers previously mentioned. This condition is named maple syrup urine disease (MSUD) and is significantly higher in Amish, Mennonites and Jewish decent. These branched-chain amino acids share the same transport protein into the brain with the aromatic amino acids (tryptophan, tyrosine, and phenylalanine).

 

[badger2]

Badger2 has been banned from posting to the Charlie Gard thread. Note that, without knowing it, we made an Amish link about the same time that the Charlie Gard thread made an Amish link.

 

[badger2]

Yes, as Coyote states, Charlie was diagnosed with epileptic encephalopathy in December. We are interested in the threat of epileptiform EEG due to sevoflurane for the MRI performed on Charlie Gard on 7 October 2016, several months earlier.

 

[badger2]

Flacaltenn was the one that tweaked, stating that Putin has nothing to do with Charlie Gard. Flacaltenn's fascist power prevents a reasoning that would include perpetrators of nosocomial mischief. It is indeed possible that Charlie Gard's anesthesiologist (anonymous) knew about azisevoflurane before the published article appeared in March. Because Charlie Gard's case has to do with genealogy, it's obvious that we should get others to visit USMB to see what is going on.

Initial talking points for review would be....

1.) The Charlie Gard thread apparently cannot and will not answer the question of Charlie Gard's sedation, which links to German chemistry, which is cutting-edge sedation chemistry.

2.) The Charlie Gard thread refuses to comment upon the Rector-Gard Cemetery that links genealogy to the American rhizome when it was still resonating with Britishism. The thread does seem to agree with our Amish example of the chemistry of genealogy with its political Amish example.

 

[badger2]

We cannot guarantee that this message will stay in the thread. Facaltenn's private message to badger2 includes accusations of creating "diversions" and also uses terms such as "bait." We can think of no other media story that baits as well as the Charlie Gard story and yes, there are plenty of diversions because of the complexities involved. We will remember the Rector-Gard cemetery and the work done to gather information for this thread. Who ordered the MRI for 7 October?

 

[badger2]

Flacaltenn, the Speaking Tumor

Flacaltenn e-mail to badger2, 4 Aug 2017

' We cannot allow users to be abusive, overly aggressive, threatening, or to "troll."....Your account's access may be limited based on these actions.'

The evidence for fascism points to the geographical concepts embedded within Flacaltenn's namesake, while the same concept also points to the pathology of Masonic boy-scoutism (e.g., tracking the wife with the help of some friends). Suggested reading has to be the history of Mussolini's Italy.
***************************************************************************************************************
Because of mitochondrial depletions in Charlie Gard et al's MDS, one approach is to study the melanotic mitochondria.

'Differences in PGC1a levels in melanoma tumors have a profound impact in their metabolism, biology, and drug sensitivity.'
(Vazquez F, et al, PGC1a Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress, Cancer Cell (2013) 23: 287-301)

We suggest that readers can stay in touch with badger2's writings by keeping an eye on these two locations:

1.) Amboy, California (desert climate for plant/fish-model research).

2.) Clarkston, Washington (Mediterranean climate for plant/fish-model research).

 

[badger2]

Badger2 has nothing to do with Mormons, but does have melanoma and basal cell carcinoma. Did a Mormon molest badger2's ancestors?

Polygamous Genetic Disorder
Polygamous Genetic Disorder
'....fumarase....'

Fumarate / Melanoma / Basal Cell Carcinoma
Melanoma and basal cell carcinoma in the hereditary leiomyomatosis and renal cell cancer syndrome. An expansion of the oncologic spectrum. - PubMed - NCBI

 

[RodISHI]

From everything I have read Galangal Root was receiving the best results for melanoma. A piece soaked in hot water first to extract for tea and then directly taped over the top of moles for 48 hrs the odd shaped moles and round dark moles begin to shrink. I used it in combination with Amoxicillin for long term stomach issues I have had since I was a child. Immediate results but kinda hard on the tummy when it starts clearing out H.plylori or where documented ulcers were previously located through xrays so have something to help on had like Marshmallow root and a little cream helps too. In combination with Hydrangea the stones started breaking loose that were gain from going through detox too rapidly. It may be that a time release capsule may be needed and the roots ground finely to get more of the roots properties into the lower intestinal tract for some. Plus side of it all was I was able to regain some skin tone/strength so therefore internally things were obviously improving healing too through high nutrition and greens such as the Nettle (I ground and canned it in alcohol while it was still fresh to attempt to retain the goods in it. Did the same with Mulberry leaf and started adding a spoonful or three a day of Nettle to routine of high chlorophyll herbs and greens, "C", b' complex plus a mixture of cartilage builder I'd mixed up for Rod I'll have to go back through my notes for what all is in it if you want to know).


Antiproliferative activity and induction of apoptosis by Annona muricata (Annonaceae) extract on human cancer cells
...................Previous reports have demonstrated that the leaf, twigs, root, stem, and fruit seed extracts of A. muricata have several biological activities such as anti-bacterial [9], antifungal [10] and anti-malarial [11]. Its leaf extract were also found to possess antioxidant [12] and molluscicidal properties [13]. Recently, it has also been reported to exhibit anti-inflammatory and analgesic effects [14], cytotoxicity and apoptosis inducing activities on T47D breast cancer [15], antiviral activity [16] and antidiabetic activity. Phytochemical investigation of the leaf of A. muricata showed the presence of alkaloids [17], essential oils [18] and acetogenins [19]. These acetogenins demonstrated to be selectively toxic against various types of the cancerous cells without harming healthy cells [20]. Acetogenin 1 was reported to exhibit cytotoxic activities against the human pancreatic tumor cell line (PACA-2), human prostate adenocarcinoma (PC-3) and human lung carcinoma (A-549), while Acetogenin 2 was reported to exhibit cytotoxicity against human hepatoma carcinoma cell line (Hep G2) [21]. Seven isoquinoline alkaloids including reticuline, coclaurine, coreximine, atherosperminine, stepharine, anomurine and anomuricine have been isolated from the leaves, root and stem barks of A. muricata[22]. The essential oil of the fresh fruit pulp of A. muricata contains 2-hexenoic acid methyl ester (23.9%), 2-hexenoic acid ethyl ester (8.6%), 2-octenoic acid methyl ester (5.4%), 2-butenoic acid methyl ester (2.4%), β-caryophyllene (12.7%), 1,8-cineole (9.9%), linalool (7.8%), α-terpineol (2.8%), lialyl propionate (2.2%) and calarence (2.2%) [23]. Therefore, we attempted to investigate the growth-inhibitory and apoptotic effects of extracts from leaf, twigs and roots from A. muricata against Human promyelocytic leukemia (HL-60 cells)................

Lots of studies and articles on lung, prostate and other cancer cell lines that Soursoap leaves have been effective in killing. human trials in India for Colon cancer but the results are not published yet.
Anti-cancer effect of Annona Muricata Linn Leaves Crude Extract (AMCE) on breast cancer cell line. - PubMed - NCBI
Anti-cancer effect of Annona Muricata Linn Leaves Crude Extract (AMCE) on breast cancer cell line.

Long-term efficacy and safety of aromatase inhibitor use for leiomyomatosis peritonealis disseminata. - PubMed - NCBI
Long-term efficacy and safety of aromatase inhibitor use for leiomyomatosis peritonealis disseminata.


Last but not least: Hereditary leiomyomatosis and renal cell cancer syndrome: A novel mutation in the FH gene. - PubMed - NCBI
J Dermatol. 2017 Jul 10. doi: 10.1111/1346-8138.13955. [Epub ahead of print]
Hereditary leiomyomatosis and renal cell cancer syndrome: A novel mutation in the FH gene.

FH gene at DuckDuckGo


Fumarase - Wikipedia
Fumarase (or fumarate hydratase) is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to malate. ... The FH gene contains 10 exons.


Chickens and Hen plants pure malic acid. It can also be gotten through other sources that are more yummy like Apple juice concentrate.

l malate at DuckDuckGo

 

[RodISHI]

We also started using honey in place of sugar over a year ago and I have taken Ginger either candied or cooked in honey for years to help offset the chemical damage to my lungs and esophagus..

https://www.researchgate.net/publication/51031361_Honey_induces_apoptosis_in_renal_cell_carcinoma
Honey induces apoptosis in renal cell carcinoma
Honey decreased the cell viability in the malignant cells in a concentration- and time-dependent manner. The IC (50) values against the ACHN cell lines were determined as 1.7 ± 0.04% and 2.1 ± 0.03% μg/mL after 48 and 72 h, respectively. Honey induced apoptosis of the ACHN cells in a concentration-dependent manner, as determined by flow cytometry histogram of treated cells. It might be concluded that honey may cause cell death in the ACHN cells, in which apoptosis plays an important role. Most of the drugs used in the cancer treatment are apoptotic inducers, hence apoptotic nature of honey is considered vital.
Honey induces apoptosis in renal cell carcinoma. Available from: https://www.researchgate.net/publication/51031361_Honey_induces_apoptosis_in_renal_cell_carcinoma [accessed Aug 12, 2017].

Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line
Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line (MCF-7)