Further links to Guttmacher syndrome for Hox genes are the nipah virus of Peter Daszak, who collected the Yunnan bat virus (2011) that Ralph Baric studied at Chapel Hill, the latter virus that once tampered with and found more dangerous, was allowed to proceed with research according to Sorensen, Dalgleish and Susrud's report (USMB search 'Sorensen, et al.')
We have already mentioned HOXA13 (HOX13A) here at USMB. Note that the chimpanzee-based SARS-CoV-2 vaccine links to the gain of function differences between the evolution of the thumbs of human and chimp, extant in the published literature:
'In the developing limb, one function of HOXA13 is to promote the growth of mesenchyme, particularly preaxial tissues that will give rise to the thumbs or great toes, as well as aggregation, cell adhesion, and perichondrial boundary formation in the autopod through the regulation of EphA7 receptor, ephrin A3 ligand, and bone morphogenic protein 2 (Bmp2) and Bmp7 expressions. In the vascular walls of the umbilical arteries, HOXA13 deficiency reduces EphA7 and EphA4 expression, and there is a failure of cell sorting between the endothelium and the vascular mesenchyme. Hoxa13 is also expressed early along the length of the Mullerian ducts and is subsequently restricted in expression to the cervix and vagina.
Hypospadias in Hoxa13-mutant mice is associated with reduction of expression of Bmp7 and Fgf8 in the urethral plate epithelium, which is associated with loss of Bmp-regulated apoptosis in the urethra. Thus, the role of HOXA13 in embryogenesis is both promotion of growth and organization of mesenchymal condensation in the limbs, cellular stratification with the umbilical arteries, as well as definition of tissue boundaries of male and female reproductive organs. HOX protein exert their effects at multiple levels in developmental pathways by promoting or altering expression of other genes at executive levels as well as through effects on cell adhesion, the cell cycle, cell death, and cell migration.'
(Epstein, Inborn Errors of Development, p. 670 HOXA13 and the Hand-Foot-Genital and Guttmacher Syndromes)
The ephrin gene links to Daszak and the Mojiang Nipah Virus, from the same cave from which the RaTG13 coronavirus emerged:
25 Jun 2021 Mojiang Virus Ephrin Receptor, Post # 528
Catholic puppet, Fauci, knows that Selamectin (trade name) by Pfizer, Ltd., has been used to treat Demodex parasites in the natural reservoir of SARS-CoV, masked palm civet, Paguma larvata. (2015) Paguma / Demodex https://pubmed.ncbi.nlm.nih.gov/26352967 ’....with the presence of a Sarcoptidae...
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13 Sep 2021 Daszak / Ephrin / Nipah Virus, Post #51
Variants may share some of the the same mutations, an expression of the virus-host relationship, which history must include non-human hosts. Nipah also implicates pigs, so we pay attention to the (Indian [italics]]) study that suggests SARS-CoV-2’s most ancient ancestor is a pig virus. The...
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