COVID-19’s Biological Politics

[badger2]

Catholic puppet, Fauci, knows that Selamectin (trade name) by Pfizer, Ltd., has been used to treat Demodex parasites in the natural reservoir of SARS-CoV, masked palm civet, Paguma larvata.

(2015) Paguma / Demodex

MITE INFECTION IN A MASKED PALM CIVET (PAGUMA LARVATA) TREATED BY SELAMECTIN (STRONGHOLD®, PFIZER LTD.) - PubMed

The masked palm civet (Paguma larvata) is a small Asian mammal (order Carnivora, family Viverridae) uncommon in Italy. Limited information is available about management and sanitary maintenance in captivity. A 4-mo-old masked palm civet presented with pruritus, itch, scratching, and disorexia...

pubmed.ncbi.nlm.nih.gov

’....with the presence of a Sarcoptidae mite and Demodex speices....a notoedric mange was thought to be the main problem....Selamectin, Pfizer, Ltd.’

Another natural reservoir of SARS-CoV is raccoon dog, Nyctereutes procyonoides:

(2001) Nyctereutes / Sarcoptes scabiei

Mange caused by Sarcoptes scabiei (Acari: Sarcoptidae) in wild raccoon dogs, Nyctereutes procyonoides, in Kanagawa Prefecture, Japan - PubMed

Parasitological and histopathological examinations were performed in 25 raccoon dogs (Nyctereutes procyonoides) obtained in Kanagawa Prefecture, Japan, all of which were found to be heavily infected with Sarcoptes scabiei. The mites detected on these raccoon dogs were morphologically...

pubmed.ncbi.nlm.nih.gov

’....No Demodex mites were detected....’

(1998) Trichosurus / Ivermectin

The effects of parasites on a wild population of the Mountain Brushtail Possum (Trichosurus caninus) in south-eastern Australia - PubMed

The effects of a reduction of parasite burdens were determined in adult female Mountain Brushtail Possums, Trichosurus caninus, on the birth, mortality and growth rates of pouch-dependent young, as well as the haematological and serum biochemical values of the mothers. The efficacy of the...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

Trichosurus mycobacterial infection previously mentioned, links to mycobacterial infection of two natural reservoirs of SARS-CoV:

Oct 2020 Japan: Paguma / Nyctereutes / Mycobacterium / Azithromycin

ISOLATION AND ANTIMICROBIAL SUSCEPTIBILITIES OF NONTUBERCULOUS MYCOBACTERIA FROM WILDLIFE IN JAPAN - PubMed

Nontuberculous mycobacteria (NTM) are opportunistic pathogens of humans and animals and are transmitted among the environment, wildlife, livestock, and humans. The aim of this study was to investigate the rate of isolation and antimicrobial susceptibility of NTM in wildlife. In total, 178...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

On the agenda, we will take a closer look at what coronaviruses might “think” about branched-chain amino acids and the aminos they use for some of their more salient mutations.

We’ve already mentioned Selamectin (Pfizer, Ltd.) use in the SARS-CoV reservoir, Paguma, and mefloquine for the rapid metabolizer of xenobiotics, Trichosurus.

Ivermectin, Selamectin, abamectin, are macrocyclic lactones and resistance mutations have been reported. For example, MDR1 gene resistence mutations will link MDR1 in Mycobacterium spp., vectored by the brushtailed opossum. Susceptibility of UK canines to lungworm can be compared with lungworm infections of Australian felines:

2000 Australia / Cat Feline Immunodeficiency Virus Infection / Lungworm / Abamectin

Pulmonary cryptococcosis and Capillaria aerophila infection in an FIV-positive cat - PubMed

A 12-year-old, FIV-positive, domestic longhair cat was presented with a history of sneezing and coughing during the previous seven months. On thoracic radiographs, a prominent bronchial pattern and three focal, opacified nodules were seen. Cytology of bronchoalveolar lavage fluid demonstrated...

pubmed.ncbi.nlm.nih.gov

Jun 2021 Bangladesh Coronavirus / Selamectin

Potential Drugs for the Treatment of COVID-19: Synthesis, Brief History and Application - PubMed

Coronaviruses (CoVs) belong to the Betacoronavirus group, an unusually large RNA genome characterized by club-like spikes that project from their surface. An outbreak of a novel coronavirus 2019 (nCOVID-19) already showed a unique replication strategy and infection that has posed significant...

pubmed.ncbi.nlm.nih.gov

May 2020 Beijing / Pangolin / COVID-19 / Mefloquine / Cepharanthine

Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus-related coronavirus model - PubMed

Our pangolin coronavirus GX_P2V is a workable model for 2019-nCoV research. CEP, selamectin, and mefloquine hydrochloride are potential drugs for treating 2019-nCoV infection. Our results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and further study of CEP for...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

We have a strong clue to the Australian tree, Codonocarpus used by Aborigines for oral cancer when comparing the N501Y mutation of SARS-CoV-2. Using the chart in post #519 in comparing the 8 coronavirus in post #518, shows that all 8 at position 501 are branched-chain amino acids. Indeed, Codonocarpus (sequesters [italics]) branched-chain amino acids. Unfortunately, we cannot link it to adenocarcinoma as we might wish, because the information is esoteric in the Australian government archives. There was no reply to our request for the document from a prominent Australian ethnobotanist.

 

[badger2]

It was on OP Disir’s thread, 11 Ap 2021, that we first mentioned the K417N/T COVID-19 mutation found only in the P.1 Brazil-Japan variant complex of mutations. Some time later, the CDC page was changed, eliminating the N (asparagine). Both the N and T link to mutations in the mu-opioid receptor, rendering increased potency of fentanyl, fentanyl itself originating in a division of Johnson & Johnson, Janssen Pharmaceutica.

South African variant can 'break through' Pfizer vaccine, Israeli study says

The coronavirus variant discovered in South Africa can "break through" Pfizer/BioNTech's COVID-19 vaccine to some extent, a real-world data study in Israel found, though its prevalence in the country is low and the research has not been peer reviewed. The study, released on Saturday, compared...

www.usmessageboard.com

Examining the 8 coronaviruses in post #518 shows that at position 417 of the spike, human coronavirus links to feline coronavirus, FIPV, the T and the N in the column, respectively. Thus, what may have been attempted in the removal at the CDC variants page, was the original link to felines found in the P.1 variant.

 

[badger2]

On the other hand, the feline infectious peritonitis virus spike that shows N at position 417 could link to powerful peritoneal macrophages involved in rabies series of vaccinations given in the stomach (‘sledgehammer’).

Dec 2020 Bronx, New York: Asymptomatic COVID-19 Infection / Peritoneum

SARS-Cov-2 Was Not Found in the Peritoneal Fluid of an Asymptomatic Patient Undergoing Laparoscopic Appendectomy - PubMed

SARS-CoV-2 was not found in the peritoneum of a single patient with asymptomatic infection. Further studies comparing SARS-CoV-2 surgical candidates are needed to address safety concerns.

pubmed.ncbi.nlm.nih.gov

’....SARS-CoV-2 was not found in the peritoneum of a single patient with asymptomatic infection.’

 

[badger2]

More studies here on the peritoneum link to asymptomatic C-19:

Jun 2021 Guadalajara (Espanol) Hydxroxychloroquine-Azithromycin / Non-Surgical Spontaneous Pneumoperitoneum / COVID-19 / Severe Bilateral Pneumonia

Non-surgical spontaneous pneumoperitoneum in a COVID-19 positive patient with severe bilateral pneumonia - PubMed

Non-surgical spontaneous pneumoperitoneum in a COVID-19 positive patient with severe bilateral pneumonia

pubmed.ncbi.nlm.nih.gov

This Bristol study, which shows C-19 rarely in urine, will link to another Bristol study for the ephrin connection to the Mojiang henipahvirus as well as to our forthcoming trajectory for Trichosurus urine:

Mar 2021 Bristol, UK

COVID-19 (SARS-CoV-2) in Non-Airborne body fluids: A systematic review & Meta-analysis - PubMed

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been predominantly respiratory. This study aimed to evaluate the presence of virus in non-airborne body fluids as transmission vehicles. Medline, EMBASE, and Cochrane Library databases were searched from December 01, 2019...

Pubmed.ncbi.nlm.nih.gov

’....rarely in urine....’

The powerful peritoneal macrophage response for rabies vaccination compares to the absences in COVID-19:

Jul 2020 Azithromycin / Hydroxychloroquine / Peritonism

Histopathological findings in a COVID-19 patient affected by ischemic gangrenous cholecystitis - PubMed

Ischemic gangrenous cholecystitis can be a tardive complication of COVID-19, and it is characterized by a dysregulated host inflammatory response and thrombosis of medium-size vessels.

pubmed.ncbi.nlm.nih.gov

‘....at day 32, patient revealed abdominal pain without signs of peritonism at examination....with a remarkable activity of macrophages (anti-CD68)....ischemic gangrenic cholecystitis....’

Pressurized Intraperitoneal Aerosolized Chemotherapy (Florida, Arabia, Germany)

COVID-19: impact on colorectal surgery - PubMed

This paper evaluates the issues surrounding these challenges including the OR environment and AGPs which are germane to surgical practices around the world. Although there is no single universally agreed upon set of answers, we have presented what we think is a balanced cogent description of...

pubmed.ncbi.nlm.nih.gov

As sensed yesterday in this thread, the Italians asked in 2020:

Sep 2020 Italy: Are They The Same?

Feline infectious peritonitis (FIP) and coronavirus disease 19 (COVID-19): Are they similar? - PubMed

SARS-CoV-2 has radically changed our lives causing hundreds of thousands of victims worldwide and influencing our lifestyle and habits. Feline infectious peritonitis (FIP) is a disease of felids caused by the feline coronaviruses (FCoV). FIP has been considered irremediably deadly until the last...

pubmed.ncbi.nlm.nih.gov

’....FIP has been considered irremediably deadly until the last few years....one of the most promising therapeutic compounds against FIP, remdesivir....’

 

[badger2]

One can arrive at Mojiang (Tongguan), the location of SARS-CoV-2’s closest relative, by viewing this map:

Jinghong

Jinghong is the capital of Xishuangbanna in southern Yunnan. Jinghong has about 643,000 residents. Mapcarta, the open map.

mapcarta.com

(Note that the Chinese expressway comes near to both Tongguan and Mengla. It also connects to the animal market at Kunming. These nearby rivers flow into Vietnam and Hanoi, so we will digress a bit on the history of Calmette, of the Calmette-Guerin (BCG) for Mycobacterium in connection with Trichosurus.

Mojiang Virus Ephrin Receptor

Idiosyncratic Mòjiāng virus attachment glycoprotein directs a host-cell entry pathway distinct from genetically related henipaviruses - PubMed

In 2012, cases of lethal pneumonia among Chinese miners prompted the isolation of a rat-borne henipavirus (HNV), Mòjiāng virus (MojV). Although MojV is genetically related to highly pathogenic bat-borne henipaviruses, the absence of a conserved ephrin receptor-binding motif in the MojV...

pubmed.ncbi.nlm.nih.gov

’....Absence of a conserved ephrin receptor binding motif....indicates a differing host-cell recognition mechanism. We confirm the inability of MojV-G to interact with known paramyxoviral receptors....independent from a well-characterized ephrin B2/B3, sialic acid and CD 150-mediated entry.’

The Bristol, UK ephrin study:

Jun 2019 Ephrin Receptor Facilitates Macrophage Recognition of Differentiating Human Erythroblasts

Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts - PubMed

Erythropoiesis is one of the most efficient cellular processes in the human body producing approximately 2.5 million red blood cells every second. This process occurs in a bone marrow niche comprised of a central resident macrophage surrounded by differentiating erythroblasts, termed an...

pubmed.ncbi.nlm.nih.gov

May 2021 Ok., R.I., India, Indiana, N.C., Connecticut, Malaysia:
Ephrin Receptor / COVID-19

Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approaches - PubMed

While protein-protein interaction is the first step of the SARS-CoV-2 infection, recent comparative proteomic profiling enabled the identification of over 11,000 protein dynamics, thus providing a comprehensive reflection of the molecular mechanisms underlying the cellular system in response to...

pubmed.ncbi.nlm.nih.gov

’....Ephrin receptor A2 (EPHA2) was identified by 11 studies including all proteomic platforms, suggesting it as a potential future target for SARS-CoV-2 infection mechanisms and development of new therapeutic strategies. We further discuss potentials of future proteomics strategies for identifying prognostic SARS-CoV-2 responsive age-, gender-dependent, tissue-specific protein targets.’

Jun 2021 Sloan-Kettering, Brigham and Women’s Hospital, SUNY Downstate Health Sciences, Brooklyn: EPH A1 Signaling Pathway

Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19 - PubMed

More than 3.5 million people have died globally from COVID-19, yet an effective therapy is not available. It is, therefore, important to understand the signaling pathways that mediate disease progression in order to identify new molecular targets for therapeutic development. Here, we report that...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

In post #528, one can compress the map with the fingers to find the location of Mengla and Tongguan. Mengla is closest to North Vietnam, a large reservoir at the Yayangshan Dam, is just south of Tongguan.

 

[badger2]

The Bristol study (Jun 2019) states: ‘We detect a rise in integrin activation on erythroblasts at the stage at which the cells bind which is independent of EPH receptor presence....we show that specific inhibitory peptides of shRNA depletion of EPHB4 cause a significant decrease in the ability of macrophages to interact with erythroblasts but do not affect integrin activation....EPHB4 expression is required on erythroblasts to facilitate initial recognition and subsequent interaction with macrophages, alongside the presence of active integrins.’

 

[badger2]

Because the George Floyd-Derek Chauvin story links to opioid addiction, and because both the SARS-CoV-2 in Floyd’s brain as well as the fentanyl in Floyd’s brain link to precisely one vaccine, Johnson & Johnson, the investigation returns to the pre-cART treatment era for HIV-1. One reason for review is due to opioid’s neurological influence on HIV-1 infection. Furthermore, the pre-cART treatment era would synchronize with the evolution of SARS-CoV-2’s closest relative, RaTG13 from Mojiang County, especially opioid addiction and HIV-1 in Southeast Asia. Another reason for review is because retroviral elements can integrate into the coronavirus genome.

 

[badger2]

We will shortly link Yunnan Province and Vietnam to CYP2D6 polymorphisms, which we think is a factor in thromboembolism and CYP2D6 in Americans, via this report for Astrazeneca vaccine:

23 Jun 2021 Thromboembolism / Astrazeneca / COVID-19

Blood clots and bleeding events following BNT162b2 and ChAdOx1 nCoV-19 vaccine: An analysis of European data - PubMed

The involvement of viruses and SARS-CoV-2 in autoimmune diseases is well known. The recent demonstration that ChAdOx1 nCoV-19 Covid-19 (AstraZeneca) vaccine (ChA) favors the production of anti-platelet factor 4 (anti-PF4) antibodies, blood clots, and thrombocytopenia raises the question of...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

An Australian scientist refutes the lab leak theory and says none got sick at the Wuhan lab:

28 Jun 2021 An Australian Scientist Who Was the Only Foreigner at the Wuhan Virus Lab Says She Never Got COVID-19 and Doesn’t Believe the Center Leaked It

An Australian scientist who was the only foreigner at the Wuhan virus lab says she never got COVID-19 and doesn't believe the center leaked it

Danielle Anderson, 42, worked at the Wuhan Institute of Virology's BSL-4 lab until November 2019. She told Bloomberg News she saw no sign of illness.

www.yahoo.com

’....What people are saying is just not how it is....not aware of anyone falling ill at the time....very, very extensive training....’

 

[badger2]

Another report on Danielle Anderson has more details:

https://www.newsmax.com/news/newsfront/2021/06/27

’....”It’s exceedingly difficult to actually make it work when you want it to work,” she said....targeted by U.S. extremists in early 2020....”The virus was in the right place at the right time and everything lined up to cause this disaster.” ‘

Agreeing with Anderson, the trajectory will further investigate the use of adenoviruses such as Ad26, a rarer virus than Ad5, as well as differences found in Homo sapiens CYP2D6 for the metabolism of xenobiotics. We have already mentioned Australian brush-tailed possum, Trichosurus as as rapid metabolizer of xenobiotics, though this rapidity in humans causes a CYP2D6 deficit. We think this deficit not only links to Trichosurus being capable of sustaining a reservoir for Mycobacterium bovis in Australia, but also CYP2D6-linked human malaria in Yunnan and Vietnam.

CYP2D6

CYP2D6 - Wikipedia

en.wikipedia.org

 

[badger2]

https://Www.newsmax.com/newsfront/2021/06/27/id/1026611/

 

[badger2]

The Last – And Only – Foreign Scientist in The Wuhan Lab Speaks Out

Danielle Anderson was working in what has become the world's most notorious laboratory just weeks before the first known cases of Covid-19 emerged in central China. Yet, the Australian virologist still wonders what she missed.

www.newsmax.com

 

[badger2]

We mentioned mefloquine for Trichosurus in post #523 and its rapid xenobiotic metabolism, chloroquine and hydroxychloroquine will link malaria/Mycobacterium in Yunnan and Vietnam in comparing differences in xenobiotic metabolism linked to CYP2D6.

COVID-19’s Biological Politics

Catholic puppet, Fauci, knows that Selamectin (trade name) by Pfizer, Ltd., has been used to treat Demodex parasites in the natural reservoir of SARS-CoV, masked palm civet, Paguma larvata. (2015) Paguma / Demodex https://pubmed.ncbi.nlm.nih.gov/26352967 ’....with the presence of a Sarcoptidae...

www.usmessageboard.com

’....rapid metabolizer of xenobiotics, Trichosurus....’

 

[badger2]

Interethnic differences of CYP2D6 in the U.S.

Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implications - PubMed

DNA polymorphisms have been identified in the genes encoding a number of the cytochrome P450 (CYP) enzymes, leading to wide interindividual variation in drug clearance. CYP2D6 metabolizes a significant number of clinically used medications, and genetic variants of the CYP2D6 isozyme that result...

pubmed.ncbi.nlm.nih.gov

Aug 2020 Ft. Detrick: CYP2D6 Polymorphism Genotyping / Cambodia/ Clinical Failure of Primaquine

Prevalence of CYP2D6 Genotypes and Predicted Phenotypes in a Cohort of Cambodians at High Risk for Infections with Plasmodium vivax - PubMed

Clinical failure of primaquine (PQ) has been demonstrated in people with CYP450 2D6 genetic polymorphisms that result in reduced or no enzyme activity. The distribution of CYP2D6 genotypes and predicted phenotypes in the Cambodian population is not well described. Surveys in other Asian...

pubmed.ncbi.nlm.nih.gov

 

[Rigby5]

An Australian scientist refutes the lab leak theory and says none got sick at the Wuhan lab:

28 Jun 2021 An Australian Scientist Who Was the Only Foreigner at the Wuhan Virus Lab Says She Never Got COVID-19 and Doesn’t Believe the Center Leaked It

An Australian scientist who was the only foreigner at the Wuhan virus lab says she never got COVID-19 and doesn't believe the center leaked it

Danielle Anderson, 42, worked at the Wuhan Institute of Virology's BSL-4 lab until November 2019. She told Bloomberg News she saw no sign of illness.

www.yahoo.com

’....What people are saying is just not how it is....not aware of anyone falling ill at the time....very, very extensive training....’

Good point in that an experienced lab like this would have quickly quarantined and identified the virus.
They are experts in contact tracing as well, so it seems unlikely the lab could have been the source.

I would have put the lab there because of the presence of natural virus diversity like bat viruses, not to test experimental weapons.

 

[Rigby5]

Since Danielle Anderson was working with far more lethal viruses at the Wuhan lab, like Ebola, its seems unlikely to be the source of a covid-19 leak.