Having linked Rab7 to Zika, comparable is the Rab7 passage in Epstein's Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis, the link was to Charcot-Marie-Tooth disease:
'Mutations in the small GTPase Rab7 cause a peripheral sensory neuropathy called Charcot-Marie-Tooth disease type 2B (CMT2B). Rab7 regulates the recruitment of dynein/dynactin to endocytic compartments and trafficking in the late endocytic pathway. Importantly, Rab7 was also shown to control the trafficking and signaling of the nerve growth factor receptor, TrkA, suggesting that Rab7 defects may contribute to neurodegeneration by affecting transport of neurotrophins of their receptors. Another type of CMT2A, is due to a loss-of-function mutation in the motor domain of the plus-end directed microtubule motor KIF1Bbeta. Studies in heterozygous kif1B+/- mice revealed that reducing the gene dosage leads to impaired anterograde axonal transport of synaptic vesicle precursors. This reinforces the idea that disturbed axonal transport is a major problem in CMT2A.'
Thus, a Pubmed keyword search, 'coronavirus charcot-marie-tooth' yielded only one reference:
Aug 2020 COVID-19 / ALS / Charcot-Marie-Tooth
Coronavirus disease 2019 has created unprecedented challenges for amyotrophic lateral sclerosis (ALS) clinical care and research in the United States. Traditional evaluations for making an ALS diagnosis, measuring progression, and planning interventions rely on in-person visits that may now be...
www.ncbi.nlm.nih.gov
'Johns Hopkins, Columbia University Neurological Institute, Cedars-Sinai, Emory U., Washington University School of Medicine, Hershey Medical Center, Duke U., Barrow Neurological Institute.
Conflict of Interest Statement.....R.B. has consulted for Modulus Pharmaceuticals, Mitochondria in Motion, Acurastem, Sarepta....and the Charcot-Marie-Tooth Association.'
R.B. is Cedars-Sinai, Los Angeles.
www.avianflutalk.com
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