Snake Meat......source of chinese virus

[badger2]

Sooner or later, Homo sapiens' science will be forced to take a closer look at conjunctivitis in Chrysemys painted turtles. Because the eye, also containing ACE2 receptors, is an organ both inside and outside the body, reasoning suggests that a virus would temporarily evolve in this intermediate zone of a host.

10 Jul 2020 Is COVID-19 Airborne? WHO Issues New Guidance

Is COVID-19 airborne? WHO issues new guidance

Goya is facing calls for a boycott after CEO says U.S. "blessed" to have Trump as a leader.

www.news.yahoo.com

'....this is not an option.'

 

[beagle9]

Sooner or later, Homo sapiens' science will be forced to take a closer look at conjunctivitis in Chrysemys painted turtles. Because the eye, also containing ACE2 receptors, is an organ both inside and outside the body, reasoning suggests that a virus would temporarily evolve in this intermediate zone of a host.

10 Jul 2020 Is COVID-19 Airborne? WHO Issues New Guidance

Is COVID-19 airborne? WHO issues new guidance

Goya is facing calls for a boycott after CEO says U.S. "blessed" to have Trump as a leader.

www.news.yahoo.com

'....this is not an option.'

Are you having a conversation with yourself here ??? On top of that, you seem to be going in circles as you attempt to show the room your medical degree's, and extensive research you have done in regards to this virus or any virus for that matter.

 

[Flopper]

Note that the transduction study above mentions that vaccines in development were based on the original D614. COVID-19 has mutated using glycine, an amino acid that has unique folding abilities compared with other amino acids.

So?

If not a virus that has been tampered with by the whu han lab, then it is a naturally occurring thing correct ??? And that is good thing.

The human being can defeat all naturally occurring viruses in the wild, but if this has been toyed with, and it has been released due to a diabolical plan of either by some sort of accidental release, then the Chinese should be charged for creating a weapon of mass destruction, and for releasing it on the world..... They should be sanctioned heavily for it by the super powers that have been affected the most, and for whom should then inturn help the smaller countries that were also hit hard by it.

Action should be taken... There is no other way if justice is to be done.

No, humans can not defeat all natural occurring viruses for example HIV.

A weaponized virus suffers from the same problem as other biological weapons. Once released they are very difficult to control if not impossible. It could easily infect China or almost as bad infect over nations intentionally or accidentally that have nuclear capability such the US or Russia.

Even if the Chinese could develop and control such a virus, why would they want to do that? Most of the country's wealth comes from exports. The Chinese communist are rolling in money thanks to Chinese exports. Killing off all your customers and possibly yourself doesn't make much sense.

You've been watching too many sci-fi movies.

HIV is a natural occuring virus in the wild ?? Where does it come from, and how do people avoid it ???

HIV crossed from chimps to humans in the 1920s in what is now the Democratic Republic of Congo.

Origin of HIV & AIDS

Where did HIV come from? Here we discuss evidence about the origin of HIV and how it came to affect humans.

www.avert.org

.

And it traveled around the entire world in some sort of linked way eh ???? Tell us about that linked way that it traveled around the world being able to infect million's upon millions ??

So you're saying that it was found in the republic of Congo, and it wasn't detected by the WHO or others immediately or within an ample amount of time before infecting most of the world with it ???

No. It was traced back to Chimps in the Congo decades later. The first human infection was detected in a blood sample in 1959 from a man in Kinshasa, Democratic Republic of the Congo. This was all done from research in in 1980's and 90's.

The WHO became involved with HIV in 2004. The role of the World Health Organization in HIV/AIDS is to help countries close the gaps in their health sectors and to help ensure that life-saving HIV services are accessible to everyone who needs them. The WHO has been the primary international organization providing HIV treatment, care, and prevention services in 3rd world countries. for over a generation.

What Trump is doing is just plain horrible. He's trying to destroy one of the primary international healthcare organizations in the world that does enormous good in 3rd world countries in order to deflect his failure to manage the covid 19 epidemic in the US. And you guys wonder why Trump is hated so much. He just doesn't give a damn about anybody or anything except himself.

Is HIV airborne ??? How did it affect so many around the world ?? What's it's primary transport from human to human ?? Is it something humans are doing that caused the epidemic to spread out of control, and if so what should have been the warnings put out by world governments to stop the virus ???

I answer stupid question but not rhetorical questions.

 

[badger2]

#720: It's transmission wasn't aggressive. In fact, the likely older of the two viruses, HIV-2, has an incubation period of twenty years. HIV-1's symptoms first appeared quite subtlely, in conditions known as "Slim" or a wasting away (Hooper, The River)

 

[badger2]

#722: We make a statements to get the ideas into screenal space first, so that others can contemplate them. 'Going in circles' is a claim that warrants substantiation, especially since the reports we are posting are from many other individuals. If one reader cannot connect the dots, other readers can, which is the combinatorial spirit of science. In post #715, snakes are invoked again, so we will reinforce the speculation again: 1.) ACE2 receptors are the target of COVID-19; 2.) There are ACE2 receptors in turtle conjunctiva. These two facts prompt a question: "Can COVID-19 subsist in or on turtle or snake conjunctiva?"

OP's snake mentioned was Bungarus (post #715). This prompts the question, "Are there ACE2 receptors in Bungarus eyes?" There certainly are ACE receptors in its liver:

Bungarus Liver ACE

Identification of a novel type of alternatively spliced exon from the acetylcholinesterase gene of Bungarus fasciatus. Molecular forms of acetylcholinesterase in the snake liver and muscle - PubMed

The venom of the snake Bungarus fasciatus contains a hydrophilic, monomeric species of acetylcholinesterase (AChE), characterized by a C-terminal region that does not resemble the alternative T- or H-peptides. Here, we show that the snake contains a single gene for AChE, possessing a novel...

www.ncbi.nlm.nih.gov

Hydroxychloroquine has been used to treat COVID-19, which can also induce hepatotoxicity:

Hydroxychloroquine Hepatotoxicity

Hydroxychloroquine-induced toxic hepatitis in a patient with systemic lupus erythematosus: a case report - PubMed

Increased serum level of liver enzymes is a common finding in patients with systemic lupus erythematosus (SLE). Hepatotoxic drugs, viral hepatitis and fatty liver are thought to be the main causes of hepatic lesion in these patients. Our aim was to determine the cause of strikingly elevated...

www.ncbi.nlm.nih.gov

This is an example of connecting the dots.

 

[badger2]

With regard to post #725 and monomeric species of ACE in Bungarus venom, we have already posted the U.S. Army Medical Research report of 1985 showing that chloroquine increases the lethality of Bungarus venom 17-fold. This is another example of connecting the dots: chloroquine links Bungarus venom, hydroxychloroquine links human hepatotoxicity.

 

[badger2]

The report below prompts questions as to the pharmacodynamics of these drugs in snake and turtle ACE:

May 2020 Mechanism of Action, Chloroquine and Hydroxychloroquine / ACE2

Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection - PubMed

The recent emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) is responsible for a worldwide pandemic. Given the global health emergency, drug repositioning is the most reliable option to design an efficient therapy for infected patients without delay. The first step of the viral...

www.ncbi.nlm.nih.gov

 

[beagle9]

#720: It's transmission wasn't aggressive. In fact, the likely older of the two viruses, HIV-2, has an incubation period of twenty years. HIV-1's symptoms first appeared quite subtlely, in conditions known as "Slim" or a wasting away (Hooper, The River)

Regardless of the incubation time periods, when it was discovered, and then it was diagnosed as a highly deadly disease having no cure, one has to ask why did measures not get taken to stop the spread of it, and especially before it killed and infected millions around the globe ????

Why wasn't every citizen tested to see if they may have been exposed or not, and then quarantined due to there not be any cure (i.e. to stop the transmission of it), otherwise where the victim would eventually die from the disease or from the complications of it, and surely the ones exposed to that person would also contract the thing, and surely would die as well ???

Was it not an invisible enemy as well, otherwise a virus that is undetectable until contacted, and very deadly also ???

Did the virus exist in the shadows, and therefore it was looked at as a cleaner of the shadows ??

 

[esalla]

The chiinese eat all kinds of exotic foods......and live with pigs in many cases....the source of most of the flu viruses that travel around the world.

.Wuhan: Chinese scientists trace coronavirus to snakes - Breitbart

Saying that the chinese live with pigs is redundant

 

[badger2]

#728: Initially, there were false positives and false negatives regarding testing as the technique was improved upon, which would take time. We're also talking about testing in Africa, not one of the world's most developed nations. One is not entirely certain that the spread was universally recognized, at least until the momentum was gathered.

 

[badger2]

Air-conditioning was already brought up on another C19 thread:

11 Jul 2020 Turn Off Your Air Conditioner

Turn off your air conditioning, experts say after WHO shifts stance on airborne coronavirus

Air conditioning units that recirculate the same air in a room should be switched off or only used with open windows, experts have urged, amid mounting concern around the role of airborne transmission to spread Covid-19. Experts told the Telegraph that air conditioning units that only used...

www.yahoo.com

'....brief that acknowledged "emerging evidence" of airborne transmission.'

 

[badger2]

This is the latest from Promedmail on origins of C19:

10 Jul 2020 WHO-Led Mission

Science | AAAS

www.sciencemag.org

 

[badger2]

We continue the interferon trajectory that first began in post #630 (21 Jun 2020) of this thread, which was the connection to MHV coronavirus PLP2 catalytic domain and the interferon-stimulated gene 15.

Differences in COVID-19 patient response to hydroxychloroquine must also consider inborn errors of innate immunity. How many were tested for these mutations before administering hydroxychloroquine? :

10 Jul 2020 Can Interferons Stop COVID-19 Before It Takes Hold?

https://www.science.sciencemag.org/content/369/6500/125

'....has found three inherited mutations that profoundly inhibit the interferon response, raising the possibility that genetic predisposition plays a role in some cases of COVID-19.'

Brazil's success with hydroxychloroquine (see thread 'FDA Hydroxychloroquine Ban, Fake Science, and Political Agendas') suggest that Brazilians have fewer genetic mutations in key genes that link the pharmacokinetics/pharmacodynamics of hydroxychloroquine as it relates to interferon production.

2018 Inborn Errors of Innate Immunity

Lessons learned from the study of human inborn errors of innate immunity - PubMed

Innate immunity contributes to host defense through all cell types and relies on their shared germline genetic background, whereas adaptive immunity operates through only 3 main cell types, αβ T cells, γδ T cells, and B cells, and relies on their somatic genetic diversification of...

www.ncbi.nlm.nih.gov

 

[badger2]

URL as found:
science.sciencemag.org/content/369/6500/125

 

[badger2]

URL will function if typed in the spacebar.

 

[badger2]

From the same author (2018 Inborn Errors of Innate Immunity), there is an r--->l mutation in GATA-2 gene, which is a link back to COVID-19 and the megakaryocytes seen at autopsy:

GATA2 Mutation

Lethal Influenza in Two Related Adults with Inherited GATA2 Deficiency - PubMed

The pathogenesis of life-threatening influenza A virus (IAV) disease remains elusive, as infection is benign in most individuals. We studied two relatives who died from influenza. We Sanger sequenced GATA2 and evaluated the mutation by gene transfer, measured serum cytokine levels, and analyzed...

www.ncbi.nlm.nih.gov

GATA-1 Mutation / Megakaryocytes

GATA Transcription Factors: Basic Principles and Related Human Disorders - PubMed

The development of mature blood cell from hematopoietic stem cells is regulated by transcription factors that coordinate the expression of lineage-specific genes. GATA transcription factors are zinc finger DNA-binding proteins that play crucial roles in various biological processes, including...

www.ncbi.nlm.nih.gov

GATA-1 Mutation / Megakaryocytes

GATA-2 reinforces megakaryocyte development in the absence of GATA-1 - PubMed

GATA-2 is an essential transcription factor that regulates multiple aspects of hematopoiesis. Dysregulation of GATA-2 is a hallmark of acute megakaryoblastic leukemia in children with Down syndrome, a malignancy that is defined by the combination of trisomy 21 and a GATA1 mutation. Here, we show...

www.ncbi.nlm.nih.gov

There are no entries for COVID-19 and either GATA gene at Pubmed.

 

[badger2]

There are, however, GATA3 links to coronaviruses:

GATA3 / Tonsillar Immune Response

Distinct regulation of tonsillar immune response in virus infection - PubMed

Tonsillar cytokine expression is closely related to existing viral infections, age, and allergic illnesses and shows distinct clusters between antiviral and immune regulatory genes.

www.ncbi.nlm.nih.gov

(2018) GATA-3 / Tonsillar Cytokine Expression

Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis - PubMed

Intratonsillar T cell and interferon gene expressions appeared to be relatively stable for both tonsillar hypertrophy and recurrent tonsillitis. Of the studied cytokines, only newly discovered anti-inflammatory cytokine IL-37, was independently associated with tonsillar hypertrophy showing...

www.ncbi.nlm.nih.gov

There is one case of tonsillitis in COVID-19 infection from Germany:

Germany / COVID-19 / Tonsillitis

Schamberg-like purpuric eruptions and tonsillitis in mild COVID-19 - PubMed

Schamberg-like purpuric eruptions and tonsillitis in mild COVID-19

www.ncbi.nlm.nih.gov

'....In our case tonsillitis may be due to SARS-CoV-2 but co-infections are not uncommon....Schamberg's disease has to be added to the list of non-specific findings of SARS-CoV-2 infection.'

 

[Flopper]

#720: It's transmission wasn't aggressive. In fact, the likely older of the two viruses, HIV-2, has an incubation period of twenty years. HIV-1's symptoms first appeared quite subtlely, in conditions known as "Slim" or a wasting away (Hooper, The River)

Regardless of the incubation time periods, when it was discovered, and then it was diagnosed as a highly deadly disease having no cure, one has to ask why did measures not get taken to stop the spread of it, and especially before it killed and infected millions around the globe ????

Why wasn't every citizen tested to see if they may have been exposed or not, and then quarantined due to there not be any cure (i.e. to stop the transmission of it), otherwise where the victim would eventually die from the disease or from the complications of it, and surely the ones exposed to that person would also contract the thing, and surely would die as well ???

Was it not an invisible enemy as well, otherwise a virus that is undetectable until contacted, and very deadly also ???

Did the virus exist in the shadows, and therefore it was looked at as a cleaner of the shadows ??

Flashback to the 1980's. HIV/AIDS was God's punish on degenerates. The tests were developed to screen blood collections to protect other from contamination. Several years later a test was made available to the general public.

 

[beagle9]

Air-conditioning was already brought up on another C19 thread:

11 Jul 2020 Turn Off Your Air Conditioner

Turn off your air conditioning, experts say after WHO shifts stance on airborne coronavirus

Air conditioning units that recirculate the same air in a room should be switched off or only used with open windows, experts have urged, amid mounting concern around the role of airborne transmission to spread Covid-19. Experts told the Telegraph that air conditioning units that only used...

www.yahoo.com

'....brief that acknowledged "emerging evidence" of airborne transmission.'

Yeah, just tell all them old people to cut off their AC, that oughta do it.... Good grief.

 

[badger2]

We next wondered if there were connections to dengue virus and GATA3, then we found t-bet:

Dengue / GATA3 mRNA Expression / T-bet

Altered T helper 1 reaction but not increase of virus load in patients with dengue hemorrhagic fever - PubMed

To investigate whether dengue-2 patients with and without dengue hemorrhagic fever had different virus load, immune mediators, or T helper (Th) reaction, we simultaneously measured virus load, immune mediators and the Th1/Th2 transcription factors T-bet/GATA-3 mRNA expression in a large outbreak...

www.ncbi.nlm.nih.gov

Then we tried t-bet and COVID-19 and retrieved only one reference:

May 2020 T-bet / COVID-19 / Lupus

Dominant extrafollicular B cell responses in severe COVID-19 disease correlate with robust viral-specific antibody production but poor clinical outcomes - PubMed

A wide clinical spectrum has become a hallmark of the SARS-CoV-2 (COVID-19) pandemic, although its immunologic underpinnings remain to be defined. We have performed deep characterization of B cell responses through high-dimensional flow cytometry to reveal substantial heterogeneity in both...

www.ncbi.nlm.nih.gov

'....This patient cluster associates tightly with biomarkers of poor outcomes and exhibits high rates of mortality....distinguished by high expression of CD11c and T-bet and are TLR7-driven.'

We have already linked hydroxychloroquine and praziquantel in this thread.

ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers: A structured summary of a study protocol for a randomised controlled trial - PubMed

The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest of expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. The...

www.ncbi.nlm.nih.gov

We link next lupus to praziquantel, and this to suspected COVID-19 intermediate host, Chrysemys:

Lupus / Praziquantel / Paragonimiasis

Paragonimiasis: an infrequent but treatable cause of hemoptysis in systemic lupus erythematosus - PubMed

Hemoptysis in systemic lupus erythematosus (SLE) may occur in up to 17% of cases. The vast majority of the cases are secondary to bacterial, tuberculosis or opportunistic infections. Also uremia, pulmonary embolism and lung hemorrhage must be considered. The majority of the above referred...

www.ncbi.nlm.nih.gov

China, 1954 / Paragonimus / Chloroquine

Chemotherapy of paragonimiasis; further observations on the efficacy of chloroquine - PubMed

Chemotherapy of paragonimiasis; further observations on the efficacy of chloroquine

www.ncbi.nlm.nih.gov

Chrysemys / Praziquantel

Fatal trematodiasis in research turtles - PubMed

During a 5-year period, 16 freshwater turtles (Trachemys scripta elegans and Chrysemys picta) that were purchased for research purposes died spontaneously. Clinical signs of disease included lethargy, constant swimming, swimming sideways, hemiplegia, and ulcerative lesions on the carapace. At...

www.ncbi.nlm.nih.gov

We next found the zinc link with a 't-bet ' search:

Argentina / T-bet / Zinc-Finger / Activated Glucocorticoid Receptor

The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction - PubMed

Glucocorticoids (GCs) immunosuppression acts via regulation of several transcription factors (TF), including activating protein (AP)-1, NF-kappaB, and NFAT. GCs inhibit Th1 cytokines and promote a shift toward Th2 differentiation. Th1 phenotype depends on TF T-bet. In this study, we examined GC...

www.ncbi.nlm.nih.gov

We next linked glucocorticoid with hydroxychloroquine

Jun 2020 Severe COVID-19 / Tocilizumab

Tocilizumab in patients with severe COVID-19: A single-center observational analysis - PubMed

Patients with coronavirus disease 2019 (COVID-19) may develop severe respiratory distress, thought to be mediated by cytokine release. Elevated proinflammatory markers have been associated with disease severity. Tocilizumab, an interleukin-6 receptor antagonist, may be beneficial for severe...

www.ncbi.nlm.nih.gov

China was also reporting on T-bet and GATA-3 mRNA in Feb 2020:

China / Pseudorabies / IgG / GATA-3 / T-bet

A Solution with Ginseng Saponins and Selenium as Vaccine Diluent to Increase Th1/Th2 Immune Responses in Mice - PubMed

Pseudorabies is an important infectious disease of swine, and immunization using attenuated pseudorabies virus (aPrV) vaccine is a routine practice to control this disease in swine herds. This study was to evaluate a saline solution containing ginseng stem-leaf saponins (GSLS) and sodium...

www.ncbi.nlm.nih.gov