Snake Meat......source of chinese virus

badger2 · Oct 6, 2020

A DO from Las Cruces is now explaining things in the media. We first noticed Epstein’s Inborn Errors of Development in the Medical Library of the University of New Mexico, Albuquerque, circa 2006.

Here we link bone morphogenetic protein to COVID-19 via pulmonary hypertension:

Bone Morphogenetic Protein / Pulmonary Hypertension

https://www.ncbi.nlm.nih.gov/15005857

Pulmonary Hypertension / COVID-19

Adult congenital heart disease and the COVID-19 pandemic - PubMed

Adults with congenital heart disease (ACHD) may be at high risk in the case of COVID-19. Due to the heterogeneity of ACHD and secondary complications, risk profiles are, however, not uniform. This document aims to give an overview of relevant data and outline our pragmatic approach to disease...

www.ncbi.nlm.nih.gov

’....severe valvular disease or pulmonary hypertension as high-risk patients.’

badger2 · Oct 6, 2020

Primary pulmonary hypertension: molecular basis and potential for therapy - PubMed

Primary pulmonary hypertension (PPH) is defined clinically by sustained elevation of pulmonary arterial pressure without a demonstrable cause, and is a progressive, often-fatal disease. PPH can be associated with ingestion of appetite suppressants, human immunodeficiency virus infection and...

www.ncbi.nlm.nih.gov

badger2 · Oct 6, 2020

Here is a general outline of the two anti-covid-19 antibodies, REGN10933 & REGN10987:

ClinicalTrials.gov

www.clinicaltrials.gov

badger2 · Oct 6, 2020

Trump‘s early dismissal from Walter Reed resonates with the Palm Trial.

Palm Trial / REGN-EB3

Independent Monitoring Board Recommends Early Termination of Ebola Therapeutics Trial in DRC Because of Favorable Results with Two of Four Candidates

The Pamoja Tulinde Maisha (PALM [together save lives]) study is a randomized, controlled trial of four investigational agents (ZMapp, remdesivir, mAb114 and REGN-EB3) for the treatment of patients with Ebola virus disease. The study began on November 20, 2018 in the Democratic Republic of the...

www.niaid.nih.gov

badger2 · Oct 7, 2020

Regarding the Chinese virus evolved from culinary promiscuity, one opportunist pathology is expressed here: “ I can’t tell you what to do except to revisit your religious beliefs and ask yourself what is right.” (Foege to Redfield, 2020)

badger2 · Oct 7, 2020

Pfizer, Moderna announce 30 million doses for Nov and Dec:

6 Oct 2020 U.S. Vaccine Program

U.S. vaccine program head Slaoui expects Pfizer, Moderna vaccine data readouts in November-December

Speaking at a symposium conducted by the Johns Hopkins University and the University of Washington, Slaoui said data readouts from leading vaccine developers are expected to come in three waves over the next several months. The first wave would be coming from Pfizer and Moderna, both of which...

www.yahoo.com.

’....there will be enough doses to immunize 30 million people between Nov and Dec.’

badger2 · Oct 7, 2020

Perusing Epstein’s Inborn Errors of Development, the bone morphogenetic protein mentioned on page 209 links to genes involved in sexual differentiation.

’Some Genes Involved in External Sexual Differentiation....Bone morphogenetic protein 4, Fgf10, Gli1, Hoxd13, and Ptch1, not implicated in sex differentiation, all showed increased expression in the Shh-treated (sonic hedgehog-treated) outgrowths (genital tubercles).’

Brachydactyly was mentioned in post #1,075. Epstein continues, p. 210:

’.... Multiple Hox genes are involved in sexual differentiation. Hypodactyly is a semi dominant mutation in mice. Due to the deficiency of Hox13. The homozygous embryos rarely survive to adulthood, but when they do they are infertile. Alfred expression of multiple Hoxd genes occur in the mouse mutation Ulnaless, and is associated with abnormalities of the penile bone. The Hoxd13 homozygous KOs (knockouts) are infertile and have altered penile bone. The compound double homozygous deficiency of Hoxa13 and Hoxd13 showed a complete absence of external genitalia, suggesting that they function in a redundant fashion....Patients with haploinsufficiency of HOXD complex had genital anomalies of small phallus, and no palpable testicles in one case and penoscrotal transposition with microbe is in a second case, as well as several limb abnormalities, while hand-foot-genital syndrome with male cryptorchidism and hypospadias is due to mutations in HOXA13.’

badger2 · Oct 7, 2020

should read ‘altered expression.’

Continuing the o.s.t.e.o trajectory, bone morphogenetic protein 4 links to both COVID-19 and dengue virus autopsies:

Lyon, France (2008) BMP4 / Megakaryocytes

BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling - PubMed

Activin A, BMP2, and BMP4, 3 members of the transforming growth factor-beta family, are involved in the regulation of hematopoiesis. Here, we explored the role of these molecules in human megakaryopoiesis using an in vitro serum-free assay. Our results highlight for the first time that, in the...

www.ncbi.nlm.nih.gov

’....Our results highlight for the first time that, in the absence of thrombopoietin, BMP4 is able to induce CD34(+) progenitor differentiation into megakaryocytes through all stages.’

Dengue Autopsy Similar to COVID-19 Autopsy