Cancer Cures

[badger2]

This Tennessee-Korea study was chosen for CD36 comparison and links to the ECM (extracellular matrix), because it mentions the 28.5 kDa weight. This in turn is quite comparable with the 27 kDa heat-shock protein in breast cancer, already mentioned in this thread:

Immunolocalization of Collagenase Inhibitor in Normal Skin and Basal Cell Carcinoma
www.jaad.org/article/S0190-9622(87)70293-X/pdf
(otherwise retrievable via the internet)

 

[RodISHI]

So if you factor in any Cytochalasin D that comes into the mix the actin filaments could be disorganized according to the studies accomplished already. Tropomyosin - Wikipedia I have also noticed that mold will grow directly into the muscle or fat tissues of pork. critters eat the toxin laden grains and people eat the meat from the critters. I would imagine that can happen with any type of food we eat. It could be there unseen by the naked eye and we wouldn't normally notice it. I have also noticed the rot in veges is totally different than it was previously when the produce becomes aged. They now sell enzymes for almost all the crops out there.

 

[badger2]

Yes, much more enzyme study seems required. The Tennessee-Korean report mentions the balance between collagenase and its inhibitor. We think that this iranian report will mesh nicely for insight into the modus operandi of basal cell carcinoma:

Iran / Marine/Human Fibroblast Collagenase
Molecular Dynamics and Docking Investigations of Several Zoanthamine-Type Marine Alkaloids as Matrix Metaloproteinase-1 Inhibitors. - PubMed - NCBI
'....enol-iminium form more inhibitory than the keto form....'

The epidermal tissues of Zoanthus are on the cutting edge of anti-basal cell carcinoma chemistry.

Zoanthus locations are southern Japan and Brazil.

Increased Resistance to UV Light
Distribution and possible function of the marine alkaloid, norzoanthamine, in the zoanthid Zoanthus sp. using MALDI imaging mass spectrometry. - PubMed - NCBI

-- The lack of a calcium carbonate skeleton meshes evolutionarily with the uveal melanoma connection to the eyes of trilobites, which are optically pure calcium carbonate. Thus NMSC (non-melanoma skin cancer) differs exemplary in Zoanthus.

-- It is found on reef flats exposed to high intensity light and intermittent strong currents.

-- It synchronizes the release of gametes with extremely low tides, which will link to circadian rhythym genes in the fish models of melanoma, such as clock, sgk2, ppargc1a, atm, etc.

-- Both intra- and extracellular methods of digestion, linking the balancing chemistry (collagenase and its inhibitor) to human BCC.

 

[badger2]

Yes, one cytochalasin D link to muscular dystrophy is here:

Cytochalasin D / Mini-Nesprin / Actin
Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts. - PubMed - NCBI

Several days ago we had made the nesprin link to beta-catenin in Emery-Dreifuss MD, and there are three subtypes:

Emery-Dreifuss Muscular Dystrophy / Nesprin / Beta-Catenin
The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin. - PubMed - NCBI

 

[badger2]

Tracking the cytochalasin D leads back to London's Dr. Taylor and the anti-tuberculosis activity of the African Geranium:

Melanoma B16 / Geranylgeranylation / Cytochalasin D
RhoA mediates the expression of acidic extracellular pH-induced matrix metalloproteinase-9 mRNA through phospholipase D1 in mouse metastatic B16-BL... - PubMed - NCBI

 

[badger2]

The B16 strain of melanoma arose spontaneously in 1954 in C67BL/6 mice. The question is, what light and/or diet factors may have been involved? Were these mice indoors, in a laboratory?

 

[badger2]

The tropomyosin link is a mayapple link (podophyllotoxin):

Tropomyosin-Related Kinase / Neuroblastoma / Etoposide
Trk inhibitor attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo. - PubMed - NCBI

Note that Trk receptors regulate apoptosis. We have already questioned in this thread, the credibility of anti-cancer cannabis for its ability (or inability) to invoke apoptosis.

 

[badger2]

We track the anti-tumor activity of the anilino moiety mentioned in the opioids-carfentanil thread:

Gandin V, et al, with Anilinopyrimidines: Discovery of N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea Derivatives as Selective Inhibitors of Class III Receptor Kinase Subfamily, Sci. Rep. [2015] 5: 16750

'....and endowed with a promising anti-tumor activity....TKIs is a challenging and fascinating goal: the ATP binding pocket is quite conserved in the entire kenome, and it is particularly conserved inside each OKs subfamily....a recurring motif in kinase inhibitors is the pyrimidine nucleus. Some symmetric 4,6-dianilinopyrimidines were reported as selective EGFR inhibitors....the 6-phenly moiety of compound 27 interacted with both the hydrophobic pocket II and the sugar pocket of the kinases.'

 

[badger2]

We now link folic acid and CD36, both previously mentioned, to the anilino moiety that links both anti-tumor activity and carfentanil:

Our search, "folic[AND]cd36" retrieved only two references:

CD36 / Folate Metabolism
Single nucleotide polymorphisms in CETP, SLC46A1, SLC19A1, CD36, BCMO1, APOA5, and ABCA1 are significant predictors of plasma HDL in healthy adults. - PubMed - NCBI

Maternal Lipid Metabolism
Maternal diets deficient in folic acid and related methyl donors modify mechanisms associated with lipid metabolism in the fetal liver of the rat. - PubMed - NCBI

Dihydropteridines in which the pyrazine ring is the site of reduction are attracting considerable current attention, not only because of their demonstrated intermediacy in folic acid metabolism, but also because of their occurrence as natural products....These compounds were readily prepared by the condensation of 3-methylamino-4-aminodimethylaniline.....The properties of these 4-methylpteridines correspond in every way with those of the des-methyl derivatives discussed above.'
(Taylor EC, Thomson MJ, Pfleiderer W, [Frick Lab, Princeton University] Synthesis and Properties of 5,6- and 5,8- Dihydropteridine Isomers, in Pteridine Chemistry, op cit)

 

[badger2]

In this thread, anilino pyrimidines have been linked to both growth factor inhibitors in cancer and to carfentanil/fentanyl moieties. With a forensic view, we note the molecular formulas for fentanyl chemistry:

Analysis of Fentanyl Chemistry
Identification of Unique Metabolites of the Designer Opioid Furanyl Fentanyl. - PubMed - NCBI

' Fu-f
C24H26N2O2

ANPP-SO4(M1)
C13H18N
C24H28N2O4
C16H19N2O4....'

As far as is known, there are no published studies comparing plant chemistry molecular formulas to these metabolites of fentanyl chemistry. In this way, the molecular formula for Fu-f metabolite would link to vincamedine (C24H28N2O4. Thus, the anti-cancer vinca alkaloids resonate with anilino pyrimidines. Phalaris tuberosa and Desmodium pulchellum alkaloids would link withC13H18N, and it isw very likely that the dimethyltryptamine moiety is instrumental in causing staggers-like poisoning in sheep in Australia. Papaver fugax main alkaloid is also comparable.

The C16H19N2O4 compares with the C16H19N3 of anabasamine from Anabasis aphylla. Noranabasamine is a minor alkaloid from the skin extracts of the Columbian poison-dart frog, Phyllobates terribilis.

 

[badger2]

To grasp Chinese historical connections to fentanyl, one must link the anti-cancer anilino moiety:

China, 1990 / N-methyl-anilino Groups
[Synthesis and analgesic activity of 1-substituted derivatives of 4-methoxycarbonyl-4-N-propionylanilinepiperidine]. - PubMed - NCBI

 

[danielpalos]

The latest research from space could imply more "natural" solutions that require no human intervention for conception.

I make a motion for a lunar presence for the greater glory of human understanding.

We could contract with the Chinese, to build lunar cities, with drug money by ending our drug war.

And, give the private sector additional profit motive.

 

[RodISHI]

I tried a small amount of that Cup-plant (Silphium perfoliatum) <good stuff. Along with a small amount of pepper or pepper tincture it is a great painkilling combo for sciatic pain. So I checked the field and discovered a whole lot of it is now growing here and there in the field since we haven't mowed the field for two seasons now.

 

[badger2]

Trending now:

14 Jun 2017 Wisconsin State Journal: 'Very Happy Surprise Very Soon'
'Pewaukee: President Donald Trump announced Tuesday during a visit to Wisconsin that he and governor Scott Walker were negotiating to bring a "major, incredible manufacturer" to the state....Walker recently traveled to Japan for a trade mission.'

There is also the problem of China's orthographic dilemma. We boycott the Chinese for many reasons, not least of which is due to the language trauma imposed on the Japanese from the beginning. At least Koreans have their own alphabet. The Japanese, however, have never gotten to see what a consonant looks like standing on its own two feet due to the pathologies inherent in the katakana-hiragana syllabary. We have already done some work towards a Japanese alphabet, and this could be used in all areas of medicine, either printed or cursive, on terrestrial or lunar surfaces.

 

[badger2]

We have already mentioned Silphium constituent, caryophyllene (C15H24) in the thread. A molecular formula comparison links alpha- & beta-alaskene from Asteriscus species, with a possible link to Tunisia for A. maritimus. Apparently, alaskene is not mentioned in Pubmed archives, although it has anti-cholinesterase activity. The reason caryophyllene is comparable to the anilino moiety already mentioned for anti-cancer pyrimidines and for fentanyl chemistry, is because both acridine and aniline are organic dyes, the former from coal tar, the latter from Indigofera species.

Anticholinesterase Activity / Acridine-Coumarin Hybrids
Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids. - PubMed - NCBI

 

[badger2]

When tracking Silphium's caryopyllene/acetylcholinesterase activity, one recalls Australian aboriginal tree already mentioned, Codonocarpus (glucosinolates), and we have already mentioned miRNAs in this thread:

Jun 2016 Acetylcholinesterase Staining / Rat Sciatic Nerve
http://www.ncbi.nlm.nih.gov/pubmed/miRNA/26909749

 

[badger2]

The rat sciatic nerve study states: 'Slides were incubated in the incubation fluid which was composed of 5mg. iodide glucosinolates acetylcholine.'

This is an important link to Codonocarpus leucine, isoleucine and valine. The tree was used by Aboriginals against cancer, as already stated, which links back to the taxonomy of the Phytolaccaceae which includes pokeweed..

 

[RodISHI]

Mulberry Morus alba and active compound oxyresveratrol exert anti-inflammatory activity via inhibition of leukocyte migration involving MEK/ERK signaling

 

[badger2]

Actually, resveratrol was isolated by Takaoka in 1939 from Veratrum alba and later from Japanese knotweed (Reynoutria). Here we'll make the fungal meningitis outbreak connection that occurred in the U.S., because Guignarida is a fungus of wild Iowa grapes and resveratrol has also been found in grape skins. Oxyresveratrol, in comparison to the fungal meningitis outbreak fungus, Exserohilum in cerabral spinal fluid (CSF), crosses the blood-brain barrier:

Oxyresveratrol / BBB
Blood-brain barrier permeability to the neuroprotectant oxyresveratrol. - PubMed - NCBI

We link CD36 to this fungal assemblage:

Resveratrol / Dectin-1 / CD36
Resveratrol modulates phagocytosis of bacteria through an NF-kappaB-dependent gene program. - PubMed - NCBI

Dectin-1 / Exserohilum
The Carbohydrate Lectin Receptor Dectin-1 Mediates the Immune Response to Exserohilum rostratum. - PubMed - NCBI

 

[badger2]

The resveratrol trajectory leads back to the Australian Aborigine tree, Codonocarpus and its use by them against cancer:

Resveratrol / Isoleucine / Branched Chain Amino Acids Isoleucine and Valine
Metabonomic variations associated with AOM-induced precancerous colorectal lesions and resveratrol treatment. - PubMed - NCBI

However, there are three branched chain amino acids: isoleucine, leucine, and valine

According to German chemistry, Codonocarpus sports all three branched chain amino acids (as a prominent physiological expression [italics]) in the tree.