It sure would be. If employers plunk some weirdo guy in a cubicle next to me and insist I use his "pronouns," first, I wouldn't. I'd call him him.
The only interesting question would be whether to quit or wait to be fired.
But I do think it's time to start taking stands. In my county they fired the Health Commissioner (big mask and mandate fan in a conservative country). This is because a lot of normal people have been coming to every county council meeting and protesting, which is NOT a normal feature of our county government, believe me. I'm watching: if they need bodies for a demonstration, I'll go.
I imagine the Council is REAL well aware a lot of us are ready to go ---- that's why they are giving way to the angry anti-maskers/anti-vaxxers. I've been in two big movements here, when some white guy wanted to make an incorporated town out of the black area and run it as his own money machine, and when they wanted to build a THREE-STORY HOMELESS SHELTER for Baltimore druggies and drunks way out here in the suburbs and destroy everyone's house values and safety. A whole lot of people turned out for that one!!! We won both times, so they are being careful now.