Snake Meat......source of chinese virus

[badger2]

We link anti-inflammatory activity of baricitinib use in COVID-19 therapy to the plant genus, Salvia. Like chloroquine and hydroxychloroquine, baricitinib is used in lupus (CLE & SLE) treatment.

14 Sep 2020 Baricitinib / Anti-Inflammatory

Anti-inflammatory drug may shorten COVID-19 recovery time

A drug company says that adding an anti-inflammatory medicine to a drug already widely used for hospitalized COVID-19 patients shortens their time to recovery by an additional day. Eli Lilly announced the results Monday from a 1,000-person study sponsored by the U.S. National Institute of...

www.yahoo.com

Baricitinib / Jak/Stat

JAK inhibitors in dermatology: The promise of a new drug class - PubMed

New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase-signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling pathway upon which many different proinflammatory signaling pathways converge. Numerous inflammatory dermatoses are...

www.ncbi.nlm.nih.gov

Stat3 / Cryptotanshinone / Salvia

Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways - PubMed

Cryptotanshinone (CTS), a lipophilic compound extracted from root of Salvia miltiorrhiza (Danshen), has demonstrated multiple pharmacological activities, including anti-inflammation, anti-proliferation and anti-infection. However, the effect of CTS on pulmonary fibrosis is unknown. This study...

www.ncbi.nlm.nih.gov

Tanshinones / SARS-CoV

Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases - PubMed

In the search for anti-SARS-CoV, tanshinones derived from Salvia miltiorrhiza were found to be specific and selective inhibitors for the SARS-CoV 3CL(pro) and PL(pro), viral cysteine proteases. A literature search for studies involving the seven isolated tanshinone hits showed that at present...

www.ncbi.nlm.nih.gov

Tanshinones link the three virus families mentioned earlier today in this thread, Retroviridae, Flaviviridae, and Hepadnaviridae.

Tanshinone II-A / HIV

Tanshinone II A inhibits tat-induced HIV-1 transactivation through redox-regulated AMPK/Nampt pathway - PubMed

Tat transactivating activity regulated by NAD(+) -dependent histone deacetylase sirtuin1 (SIRT1) connects HIV transcription with the metabolic state of the cell. Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the mammalian NAD(+) biosynthesis. Nampt, SIRT1, and AMPK...

www.ncbi.nlm.nih.gov

Tanshinone II-A / Hepatocellular Carcinoma

Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma - PubMed

Herbal compounds derived from CHM are of much significance in devising new drugs and providing unique ideas for the war against HCC. We propose that these breakthrough findings may have important implications for targeted-HCC therapy and modernization of CHM.

www.ncbi.nlm.nih.gov

 

[badger2]

Though testing on humans will not begin until 2021, Ab8 is the newest in the anti-COVID-19 arsenal, reported just 23 hours ago from University of Pittsburgh. Dimitrov spearheaded this trajectory. Here is the original 2003 report when Dimitrov was at NIH Frederick, Md.:

(Dec 2003) Dimitrov and Li / ACE2

The secret life of ACE2 as a receptor for the SARS virus - PubMed

The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.

www.ncbi.nlm.nih.gov

 

[badger2]

From Avian Flu Talk, an excellent article on ab8 with more historical information:

Tiny Antibody Component Highly Effective Against COVID-19

A molecular discovery by Pitt infectious disease scientists is being turned into a drug to treat and prevent COVID-19.

www.upmc.com

 

[badger2]

Male Bias and Lesbianism in COVID-19 Biology

Going some distance in answering male bias in C19 infections, there are homosexual clues in Ab8.

High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models - PubMed

Novel COVID-19 therapeutics are urgently needed. We generated a phage-displayed human antibody V_H domain library from which we identified a high-affinity V_H binder ab8. Bivalent V_H, V_H-Fc ab8, bound with high avidity to membrane-associated S...

www.ncbi.nlm.nih.gov

’....Vh-Fc Ab8 binding except F486A, F456A and A475I. The F486A significantly decreased binding without affecting the overall receptor binding domain (RBD) conformation.’

F is phenylalanine.

Phenylalanine and Homosexuality

Serotonin signaling in the brain of adult female mice is required for sexual preference - PubMed

A role for serotonin in male sexual preference was recently uncovered by our finding that male mutant mice lacking serotonin have lost sexual preference. Here we show that female mouse mutants lacking either central serotonergic neurons or serotonin prefer female over male genital odors when...

www.ncbi.nlm.nih.gov

....and displayed increased female to female mounting when presented either with a choice of a male and a female target or only with a female target....although preference for the opposite sex is essential for reproduction, sexual behaviors toward members of the same sex have been observed in many animal species, indicating that there are potential evolutionary advantages....although a genetic component for homosexual orientation has been suggested, no specific genes have been identified in sexual preference for sexual behaviors....We first used parachlorophenylalanine, a tryptophan hydroxylase 2 inhibitor, to pharmacologically deplete 5-HT from wild type animals.’

Thus, decreased binding of antiCOVID Ab8 is directly related to lesbianism in mice via phenylalanine, which links the RBD of COVID-19.

 

[badger2]

The Recovery trial for hydroxychloroquine comes under scrutiny for some of its suspicious parameters. We’ll be excerpting from this webpage:

https://www.francesoir.fr/oxford-recovery-hospital-test-overdose-hard- pills-swallow

 

[badger2]

Oxford-Recovery clinical trial and overdose: a hard pill to swallow | FranceSoir

Oxford is the circus of a significant scam around the Recovery clinical trial for Covid-19 therapies. Significant errors, excessive doses of hydroxychloroquine on very sick patients with many comorbidities, resulting in what may appear as "death by overdose", could easily have masked a...

www.francesoir.fr

 

[badger2]

The software clearly does not like the URL and includes the threat of theft. Nevertheless, the URL is correctly transcribed. There is some intriguing information here, an example is

’....patients received higher doses of hydroxychloroquine than other trials (400 mg every 12 hr after two loading doses of 800 mg)....Significant errors, excessive doses of hydroxychloroquine on very sick patients with many comorbidities, resulting in what may appear as ”death by overdose” could easily have masked a beneficial effect of the molecule....Moreover it is surreal that the pharmacokinetic data of plasma levels and hydroxychloroquine efficacy that should have been retained by the authors, and set out in this supporting document, were indeed measured by the Chinese researchers and published on 9 Mar.’

 

[badger2]

This recently posted at Avian Flu Talk, links to USMB Evolution of the Saxophone thread. It is not peer-reviewed.

V483a – an Emerging Mutation Hotspot of Sars-Cov-2

Exploring the biological significance of mutations in SARS-CoV-2 coronavirus, causing the COVID–19 pandemic, has recently become an area of paramount interest for many researchers, who are pouring their tremendous efforts, in cracking the COVID–19 pandemic code. One of many such mutations that...

www.preprints.org

’This information can in turn be of monumental importance in the field of vaccine and drug development because the mutants are becoming resistant to the vaccines and monoclonal antibodies.’

 

[badger2]

The C19 valine to alanine mutation we first link to the “Christchurch” mutation in post number 161 of 10 Nov 2019 of the Evolution of the saxophone thread, which stated, “Christchurch mutation sequence shows a valine flanked by two arginines....the phantom potential of alanine to valine (and vice versa), remains.“ In post number 160 of that thread, the sequence of the Japanese alanine to valine mutation at position 260 was written so that it could be transformed into music according to our isoelectric assignment, which was reproduced in post number 2 of that thread. (This new Apple IPad has some serious problems with transcription of USMB URLs at this time), and thus the reader is forced to manually go to each of the posts that we have mentioned, to view them.

 

[badger2]

In addition, it is noted that alanines play a significant role in antibody mechanisms for ab8 (post number 1,024 of this thread).

 

[badger2]

In addition, we can now link Zika alanine to valine mutation (evolution of the saxophone thread, 1 Nov 2018), because the hydroxychloroquine report in post # 1,027 of this thread, as will be shown, links to Raoult, who did not include zinc, though the tripartite Zelenko protocol did include zinc, which is anti-Zika.

 

[badger2]

Some discourse on the report in post #1,028 for the 483A mutation at Avian Flu Talk, who first posted the report, states ‘....Who the hell are preprints. Ignore it until Lancet or NEJM publish with peer review. The Boogie man. Designed to scare you.’

One would do better to look for previous connections to credibility. One of the authors of the controversial report also published on poliovirus.

Manickavsagam P / Poliovirus (Mar 2020)

Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India - PubMed

Identification of the causes of poor oral vaccine immunogenicity in low-income countries might lead to more effective vaccines. We measured mucosal and systemic immune parameters at the time of vaccination with oral poliovirus vaccine (OPV) in 292 Indian infants aged 6-11 months, including...

www.ncbi.nlm.nih.gov

On 15 Mar 2020, this report linked the V283A mutation:

Emergence of RBD mutations in circulating SARS-CoV-2 strains enhancing the structural stability and human ACE2 receptor affinity of the spike protein

A novel coronavirus SARS-CoV-2 is associated with the current global pandemic of Coronavirus Disease 2019 (COVID-19). Spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the critical determinant of viral tropism and infectivity. To investigate whether the mutations in the RBD have...

www.biorxiv.org

’....13 V483A and 7 G476S mutants from the U.S.A.....’

It would be interesting to know the geographical history of these 13 American mutants.

 

[badger2]

The above report, “Emergence of RBD Mutations,” suggests that the named strain for the V483A mutation may have come from Washington state:
’....WA-S106, 2/29
WA-S86, 3/1
WA-S19, 3/2
....
WA-UW244, 3/16
....the molecular dynamics simulations also indicated that it would be difficult for bat SARS-like CoV to infect humans. However, the pangolin CoV is potentially infectious to humans....an enhancement of the SARS-CoV-2 binding affinity to human ACE2 receptor reveals higher infectivity of the mutant strains.

It should be noted that the mutation V367F enhancing the affinity was found in six strains: one in Hong Kong and five in France. AsRBD is conserved in SARS-CoV-2, the coincidence of six strains with the same mutation across the geographic distance indicates that this mutant may have evolved to be mor robust and that these strains originated as a novel sub-lineage given the close isolation dates (Jan 22 and 23, respectively). Combined with epidemiological data, mutation surveillance is of critical importance as it can reveal more exact transmission routes of the epidemic and provide early warning for additional outbreaks.
....
Since the RBD contains important antigenic epitomes, frequent mutations in RBD, especially those which change the amino acid properties, may weaken the binding affinity of the antibody raised against the prototype strain. This may lead to decreased vaccine efficacy and should be further validated.’

 

[badger2]

If in the above excerpt, WA-S106, 2/29 represents “Washington-S106,” then the tentative date of 2/29 may be compared to our trajectory of 28 Feb, at post #555 of this thread which mentions Grant County, Washington for feline leukemia virus in (the then) suspected intermediate COVID-19 host, painted turtle, Chrysemys picta:

Snake Meat......source of chinese virus

The chiinese eat all kinds of exotic foods......and live with pigs in many cases....the source of most of the flu viruses that travel around the world. .Wuhan: Chinese scientists trace coronavirus to snakes - Breitbart So...Freer, TX is in trouble.

www.usmessageboard.com

‘Grant County’

 

[badger2]

For Grant County, Washibg

 

[badger2]

For Grant County, Washington, the highest number of cases were at Moses Lake:

granthealth.org/updates-for-covid-19-in-grant-county/
’....Moses Lake 876 cases.’

 

[badger2]

We’ll try other versions of the URL, even though the software will capitalize what is not capitalized:

2020 Updates for COVID-19 in Grant County, WA | Granthealth.org

This page includes COVID-19 updates for 2020 and will no longer be updated. For the latest information, please go to the latest COVID-19 updates page. June 24, 2020 - 5:00pm Thirty-five (35) confirmed cases of COVID-19 were reported to GCHD. We are also sad to announce death bringing the total...

granthealth.org

2020 Updates for COVID-19 in Grant County, WA | Granthealth.org

This page includes COVID-19 updates for 2020 and will no longer be updated. For the latest information, please go to the latest COVID-19 updates page. June 24, 2020 - 5:00pm Thirty-five (35) confirmed cases of COVID-19 were reported to GCHD. We are also sad to announce death bringing the total...

www.granthealth.org

 

[badger2]

It is intriguing that the COVID-19 mutation V483A may be closely linked to a virus in Chrysemys Picts bellii, the same species that occurs in China. In the report at post #555, the location of the infected turtle was a small lake 1.3 miles from Potholes Reservoir, which reservoir is 7 miles south of Moses Lake.

 

[Likkmee]

It is intriguing that the COVID-19 mutation V483A may be closely linked to a virus in Chrysemys Picts bellii, the same species that occurs in China. In the report at post #555, the location of the infected turtle was a small lake 1.3 miles from Potholes Reservoir, which reservoir is 7 miles south of Moses Lake.

It's a weapons depot !!!
Remember so-called C19 has fingerprint characteristics of both SARS and AIDS, which can NEVER happen in a cave or pond....just sayin

 

[badger2]

Picta which we will spell out