We link anti-inflammatory activity of baricitinib use in COVID-19 therapy to the plant genus, Salvia. Like chloroquine and hydroxychloroquine, baricitinib is used in lupus (CLE & SLE) treatment.
14 Sep 2020 Baricitinib / Anti-Inflammatory
Baricitinib / Jak/Stat
Stat3 / Cryptotanshinone / Salvia
Tanshinones / SARS-CoV
Tanshinones link the three virus families mentioned earlier today in this thread, Retroviridae, Flaviviridae, and Hepadnaviridae.
Tanshinone II-A / HIV
Tanshinone II-A / Hepatocellular Carcinoma
14 Sep 2020 Baricitinib / Anti-Inflammatory
Anti-inflammatory drug may shorten COVID-19 recovery time
A drug company says that adding an anti-inflammatory medicine to a drug already widely used for hospitalized COVID-19 patients shortens their time to recovery by an additional day. Eli Lilly announced the results Monday from a 1,000-person study sponsored by the U.S. National Institute of...
www.yahoo.com
Baricitinib / Jak/Stat
JAK inhibitors in dermatology: The promise of a new drug class - PubMed
New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase-signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling pathway upon which many different proinflammatory signaling pathways converge. Numerous inflammatory dermatoses are...
www.ncbi.nlm.nih.gov
Stat3 / Cryptotanshinone / Salvia
Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways - PubMed
Cryptotanshinone (CTS), a lipophilic compound extracted from root of Salvia miltiorrhiza (Danshen), has demonstrated multiple pharmacological activities, including anti-inflammation, anti-proliferation and anti-infection. However, the effect of CTS on pulmonary fibrosis is unknown. This study...
www.ncbi.nlm.nih.gov
Tanshinones / SARS-CoV
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases - PubMed
In the search for anti-SARS-CoV, tanshinones derived from Salvia miltiorrhiza were found to be specific and selective inhibitors for the SARS-CoV 3CL(pro) and PL(pro), viral cysteine proteases. A literature search for studies involving the seven isolated tanshinone hits showed that at present...
www.ncbi.nlm.nih.gov
Tanshinones link the three virus families mentioned earlier today in this thread, Retroviridae, Flaviviridae, and Hepadnaviridae.
Tanshinone II-A / HIV
Tanshinone II A inhibits tat-induced HIV-1 transactivation through redox-regulated AMPK/Nampt pathway - PubMed
Tat transactivating activity regulated by NAD(+) -dependent histone deacetylase sirtuin1 (SIRT1) connects HIV transcription with the metabolic state of the cell. Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the mammalian NAD(+) biosynthesis. Nampt, SIRT1, and AMPK...
www.ncbi.nlm.nih.gov
Tanshinone II-A / Hepatocellular Carcinoma
Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma - PubMed
Herbal compounds derived from CHM are of much significance in devising new drugs and providing unique ideas for the war against HCC. We propose that these breakthrough findings may have important implications for targeted-HCC therapy and modernization of CHM.
www.ncbi.nlm.nih.gov