Further on the transferrin trajectory, there is....
Is Transferrin A Missing Link?
'....ADAMTS13, F11, HGFAC, KLKB1 (procoagulants), two anticoagulants C1QTNF1, SERPINA5....expression of procoagulant transferrin (not associated with the Gene Ontology term, "blood coagulation") was higher in males, increased with age, and was upregulated upon SARS-CoV-2 infection.
The Italians were looking for scrapie in porpoise brains, though there are no published reports of this having occurred.
Transferrin / Prion / Scrapie
Prion disease associated neurotoxicity is mainly attributed to PrP-scrapie (PrP(Sc)), the disease associated isoform of a normal protein, the prion protein (PrP(C)). Participation of other proteins and processes is suspected, but their identity and contribution to the pathogenic process is...
www.ncbi.nlm.nih.gov
....Emerging evidence implicates an imbalance of brain iron homeostasis as a significant cause of prion disease-associated neurotoxicity....The underlying cause is change in the characteristics of ferritin, an iron-storage protein that becomes aggregated, detergent insoluble, and partitions with denatured ferritin using conventional methods of ferritin purification. A similar phenotype of iron deficiency is noted in lumbar spinal cord (SC) tissue of scrapie-infected hamsters, a site unlikely to be affected by massive neuronal death and non-specific iron deposition. As a result, the iron uptake protein, transferrin (tf) is upregulated in scrapie-infected SC tissue, and increases with disease progression.'
