Snake Meat......source of chinese virus

[badger2]

This new iPad is notoriously inept and will require an actual keyboard.
We’ll next show the connection between Coccidioides, Histoplasma, and Rhinolophus bats, which viral strains of the latter are closest in sequence similarity to SARS-CoV-2.

(2018) University of Colorado / Hydroxychloroquine / Coccidioides

Miliary Histoplasmosis in a Patient with Rheumatoid Arthritis - PubMed

Miliary histoplasmosis is a rare presentation that may mimic miliary tuberculosis. We report a case of miliary histoplasmosis in a 52-year-old male who was being treated with hydroxychloroquine, methotrexate, and sulfasalazine for his rheumatoid arthritis and presented to the emergency...

www.ncbi.nlm.nih.gov

’....Coccidioides complement immunofixation assay and Coccidioides IgM were positive....Histoplasma capsulatum was isolated....his therapy for rheumatoid arthritis comprised weekly methotrexate, daily hydroxychloroquine, and sulfasalazine. His symptoms were well controlled on this regimen. He also gave a history of rituximab for a year prior to presentation....He was started on amphotericin B. After one week, he was transitioned to oral fluconazole 400mg daily. His hypoxia resolved, and he was discharged home.’

 

[badger2]

According to the Pubmed search engine, a report from 1978 mentions both Rhinolophus and Coccidioides, though to view the report costs $35.95, and the abstract does not mention the connection. Note that the azithromycin mentioned in post# 1,059, is a crucial factor in the deceptive design of UK’s Recovery trial for COVID-19, because it intentionally avoids testing of the Raoult protocol, already mentioned this thread.

(1978) Arizona / Rhinolophus / Coccidioides

Isolation of coccidioides immitis from bat guano and preliminary findings on laboratory infectivity of bats with Coccidioides immitis - PubMed

Isolation of coccidioides immitis from bat guano and preliminary findings on laboratory infectivity of bats with Coccidioides immitis

www.ncbi.nlm.nih.gov

 

[badger2]

In post #1,059, the wife’s lung tissue being compromised was a pre-existing condition. Because llamas and alpacas also contract Coccidioides, there is scientific evidence that supports the altitudinal notion that flying before (or during?) her COVID-19 infection exacerbated susceptibility to the virus.

 

[badger2]

A new antibody directly attacks COVID-19 mutation, D614G (aspartic acid to glycine), which arose around February 2020.

2 Oct 2020 Sorrento & ViralClear Explore Combination Coronavirus Treatments

Sorrento & ViralClear Explore Combination Coronavirus Treatments

Sorrento (SRNE) collaborates with ViralClear Pharmaceuticals to evaluate the combination of antibody and antiviral assets against COVID-19.

finance.yahoo.com

’....merimepodib for possible synergistic anti-viral effect....in combination with Gilman Sciences’ Remdesivir....COVI-AMG (STI 2020; Affinity Matured COVI-AMG)....as well as a D614G SARS-CoV-2 variant....STI 2020 at 500mg reduced virus load in hamster lungs to undetectable levels in 100% of animals.’

We mentioned D614G in posts #836 and #971.

 

[badger2]

However, as will be shown, merimepodib, an inosine monophosphate dehydrogenase inhibitor, links to chloroquine and HIV therapy.

Merimepodib / IMPDH Inhibition

Low molecular weight indole fragments as IMPDH inhibitors - PubMed

The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.

www.ncbi.nlm.nih.gov

We are still tracking the phenyl moiety as it relates to homosexuality in mice (previous messages) though its activity links also to IMPDH inhibition:

Inhibitors of IMPDH (Bristol-Meyers Squibb, Princeton)

Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety - PubMed

The first reported structure-activity relationships (SARs) about the N-[3-methoxy-4-(5-oxazolyl)phenyl moiety for a series of recently disclosed inosine monophosphate dehydrogenase (IMPDH) inhibitors are described. The syntheses and in vitro inhibitory values for IMPDH II, and T-cell...

www.ncbi.nlm.nih.gov

’....SARS (structure-activity relationships) about the N-[3-Methoxy-4-(5-oxazolyl) phenyl moiety....’

(to be continued)

 

[badger2]

To make the chloroquine connection to IMPDH inhibition, we first introduce didanosine:

IMPDH Inhibition / Didanosine

Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine - PubMed

2',3'-Dideoxyadenosine (ddAdo) and its deamination product 2',3'-dideoxyinosine (ddIno) (didanosine) inhibit the replication and infectivity of the human immunodeficiency virus (HIV) in a number of in vitro assay systems. Early clinical studies (phase I) have indicated a role for ddIno in the...

www.ncbi.nlm.nih.gov

’....2’,3’-Dideoxyadenosine (ddAdo) and its deamination product 2’,3’-Dideoxyinosine (ddIno) (didanosine) inhibit the replication And infective the of the human immunodeficiency virus (HIV).’

Didanosine / Chloroquine (2001, Netherlands)

The potential place of chloroquine in the treatment of HIV-1-infected patients - PubMed

in view of the above-given data, combination therapy with chloroquine warrants clinical studies in HIV-1-infected patients, mainly in the setting of resource-poor countries.

www.ncbi.nlm.nih.gov

’....We previously found its anti-HIV-1 activity to be additive to that of hydroxyurea plus didanosine combination.’

 

[badger2]

The interesting structure-activity relationship of the phenyl moiety (post #1,065) compares with COVID-19 mutation (post #1,033) V367F, which enhances binding affinity of the antibody, also implicating a phenyl moiety. This mutation was found in six strains and as a novel sub-lineage mutation close in time.

In addition, when we add zinc as the third element in the Zelenko protocol which was zinc, hydroxychloroquine, and azithromycin (previous messages), there is a connection to merimepodib’s IMPDH inhibitory activity:

IMPDH / Zinc

https://www.ncbi.nml.nih.gov/pubmed/10965596

’....the symmetrical and unsymmetrical bis(thiosemicarbazones) complexes of copper, nickel, zinc and cadmium have been examined....the regulatory enzyme of the de novo purine pathway, IMP dehydrogenase, appeared to be a major target of the complexes....these new derivatives demonstrated excellent activity against the growth of suspended lymphomas and leukemias....’

 

[badger2]

The President’s treatment at Walter Reed will be REGN-CoV2, and this is politically charged, because it has the potential to win more of the black vote:

Regeneron Announces REGN-CoV2

https://finance.yahoo.com/news/regenerate-announces-start-reign-cov2-110000458.html

’....REGN-CoV2’s two antibodies bind non-competitively to the critical receptor binding domain of the virus’s spike protein which diminishes the ability of mutant viruses to escape treatment and protects against spike variants that have arisen in the human population, as detailed in recent Science publications.’

Regeneron previously used the same technology and cocktail approach to develop REGN-EB3, a novel triple-antibody treatment for Ebola.

 

[badger2]

Trump’s latest gesture must have impressed Putin, whose daughter has also taken a bold experimental trajectory with the new Russian vaccine. As we have stated elsewhere, romance carries a different placard in the Latin and Slavic countries, and so by default, Trump’s REGN-CoV2 trajectory should win more of the US Hispanic vote. In addition, this report is from both Germany and Rocky Mountain Labs, Montana:

Oct 2019 (EPub Jul 2019)
Anti-Ebola REGN-EB3

Therapeutic strategies to target the Ebola virus life cycle - PubMed

Following the Ebola virus disease epidemic in west Africa, there has been increased awareness of the need for improved therapies for emerging diseases, including viral haemorrhagic fevers such as those caused by Ebola virus and other filoviruses. Our continually improving understanding of the...

www.ncbi.nlm.nih.gov

’....Furthermore, with GTP inhibitors such as merimepodib and mycophenolic acid, one must consider possible effects on the many GTP-dependent host cell enzymes, some of which may function as proviral factors.’

 

[badger2]

Putting to Rest the Lab Escapee Scenario of COVID-19

In the following exegesis of the receptor binding domain (RBD) of COVID-19, the evidence shows no genetic engineering:

May 2020 COVID-19 RBD

Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism - PubMed

The spread of COVID-19 caused by the SARS-CoV-2 outbreak has been growing since its first identification in December 2019. The publishing of the first SARS-CoV-2 genome made a valuable source of data to study the details about its phylogeny, evolution, and interaction with the host...

www.ncbi.nlm.nih.gov

’....No major divergence of the interaction interface of SARS-CoV-2 RBD with hACE2 was noticed from the similarity matrix analysis. This suggests that the molecular elements required for the binding with the receptor might also be involved in the interaction with other orthologous forms of ACE2 and that these elements are not optimized specifically for the human form. Therefore it is unlikely that the interface of RBD from SARS-CoV-2 is a result of human intervention via genetic engineering aiming to increase the affinity toward ACE2. For example, residue E484 contributes unfavorably to the bonding energy with 2.24 kcal/mol due to an electrostatic repulsion with E75 from hACE2. This residue is an apparent choice for engineering a protein-protein complex with high affinity by substituting E484 with a polar residue. It is, however, noteworthy that the lesser homogeneity of the nodes of SARS-CoV-2 group, in comparison to SARS-CoV, may suggest a higher tolerance for the mutation of the new virus which would allow it to cross the species barrier more easily and to efficiently optimize the interaction in the host.’

 

[badger2]

Current media is incorrect about FDA warnings concerning hydroxychloroquine. FDA relegated that decision to physician and patient only.

 

[badger2]

That Trump’s physician prescribed hydroxychloroquine is only part of the critique to dismiss his credibility. That he is also an osteopath is another unfounded critique. Here we dispel any doubts.

Trump’s antibody therapy was with REGN-CoV2, not only linking to anti-Ebola REGN-EB3, but also to bone morphogenetic proteins:

REGN-2477 / ACVR1 / BMPs / Rapamycin

Therapeutic advances for blocking heterotopic ossification in fibrodysplasia ossificans progressiva - PubMed

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which heterotopic bone forms in muscle and soft tissue, leading to joint dysfunction and significant disability. FOP is progressive and many patients are wheelchair-bound by the 3rd decade of life. FOP is caused by an...

www.ncbi.nlm.nih.gov

’....R206H mutation appears to change signaling specificity....overactivation of these intracellular signaling pathways occurs when canonical bone morphogenetic proteins (BMPs) bind to the mutated ACVR1 receptor.’

That Trump also received Remdesivir along with REGN-CoV2, indeed links as well to Ebola virus therapy:

Ebola Therapeutics

The in vitro interaction of Trypanosoma cruzi bloodstream forms and mouse peritoneal macrophages - PubMed

The uptake and further development of bloodstream forms from T. cruzi Y and CL strains in mouse peritoneal macrophages have been investigated. Parasites from the Y strain (which present predominance of slender forms) are 20 to 30-fold more infective to macrophages than those from CL strain in...

www.ncbi.nlm.nih.gov

’....an interim analysis that showed superiority of these groups to ZMapp and remdesivir.’

Rapamycin (above) targets mTOR. Trump’s clinical obesity links precisely here, and his swift recovery should attract many non-blm obese black voters For 3 Nov 2020:

Sep 2020 COVID-19 / Obesity / mTOR as Culprit

von Willebrand disease: Diagnosis and treatment, treatment of women, and genomic approach to diagnosis - PubMed

von Willebrand disease (VWD) is the most common inherited bleeding disorder. VWD is caused by deficiencies in von Willebrand factor (VWF), a critical adhesive haemostatic protein. This review provides an overview of VWD diagnosis and treatment, special considerations in treating women with VWD...

www.ncbi.nlm.nih.gov

’....In adipose tissues, ACE2 expression levels exceed those expressed in the lung.’

 

[badger2]

The last entry was incorrectly transcribed.

Obesity and COVID-19: The mTOR pathway as a possible culprit - PubMed

Obesity and COVID-19: The mTOR pathway as a possible culprit

www.ncbi.nlm.nih.gov

 

[badger2]

Ebola therapeutics (above) is also mistranscribed:

Therapeutic strategies to target the Ebola virus life cycle - PubMed

Following the Ebola virus disease epidemic in west Africa, there has been increased awareness of the need for improved therapies for emerging diseases, including viral haemorrhagic fevers such as those caused by Ebola virus and other filoviruses. Our continually improving understanding of the...

www.ncbi.nlm.nih.gov

’....showed superiority of these groups to ZMapp and Remdesivir.’

 

[badger2]

Trump’s REGN-CoV2 links to BMPs. Here we show that Trump’s REGN-CoV2-BMP assemblage also links to Ruth Ginsberg’s pancreatic cancer.

Although Epstein’s book supposedly is not in the University of Wisconsin library system, a physical copy is indeed located at UW’s. northernmost campus. Quoting from a personal copy....

’A recurrent mutation in the BMP type 1 receptor, ACVR1, causes fibrodysplasia ossificans progressiva, a rare autosomal dominant disorder characterized by ectopic chondrogenesis and osteogenesis.
....
Mutations affecting the human BMP2/4 ligand andBMP 5/7 specific type I receptor lead to morphological defects such as brachydactyly and hereditary hemorrhagic telangiectasia, whereas mutations in the shared BMP type II receptor or the shared SMAD4 cause cancer.

Table 3-4
....ACVR1b: pancreatic carcinoma, specific type I receptor.’
(Epstein, Inborn Errors of Development, p. 40)

 

[badger2]

Trump’s antibody technology may also affect hyperlipidemic black voters.

COVID-19 / Hyperlipidemia

Incidence and Risk Factors for Acute Kidney Injury and Its Effect on Mortality in Patients Hospitalized From COVID-19 - PubMed

Acute kidney injury is a common complication among hospitalized patients with COVID-19 infection. We found significantly higher odds of AKI with increasing age and among patients with hyperlipidemia, those with chronic kidney disease, and among African Americans. We demonstrate an independent...

www.ncbi.nlm.nih.gov

’....Patients with AKI had significantly higher odds of mortality....this affect was proportional to the stage of AKI....370 patients....African-American descent.’

Hyperlipidemia / REGN-727

Inhibition of pro-protein convertase subtilisin kexin 9 [corrected] (PCSK-9) as a treatment for hyperlipidaemia - PubMed

PCSK-9 inhibition is a potentially interesting novel addition to the armamentarium of LDL-C reducing drugs. Its effects in reducing LDL-C will need to be confirmed to reduce CVD events in large-scale clinical trials.

www.ncbi.nlm.nih.gov

’....PCSK-9 mutations in familial hyperlipidemia.’

HIV / PCSK-9

Current pharmacotherapy for the treatment of dyslipidemia associated with HIV infection - PubMed

<span><b>Introduction</b>: Cardiovascular disease is an important cause of morbidity and mortality in persons with human immunodeficiency virus (PWH). The risk of atherosclerotic cardiovascular disease (ASCVD) is higher in PWH compared to uninfected persons. Dyslipidemia is a critical link in...

www.ncbi.nlm.nih.gov

’....cardiovascular disease is an important cause of morbidity And mortality in persons with HIV....PCSK-9 inhibitors are reviewed (Gilead Sciences, Janssen Pharmaceuticals).’

 

[badger2]

Janssen Pharmeceuticals was mentioned in posts #255 &256, the link is also Johnson and Johnson, HIV, etc.

Snake Meat......source of chinese virus

This was posted @ AFT one minute ago: Totally Misery -- Scene from a Chinese Hospital Twitter

www.usmessageboard.com

 

[badger2]

Probably the most scarey thing currently is to watch college-educated white females taking the dem bait and going for Biden. We must write it this way, otherwise apple’s stupid software will tweak: No, o.s.t.e.o in the most scientific sense of the word, precisely due to bone morphogenetic proteins and their implicating genes.

Trump’s Doctor a DO

Trump's doctor may be the first osteopathic physician to serve as president's top healer

With Trump's doctor Sean Conley in the spotlight, a New Mexico physician explains what osteopathic medicine is and the difference between a DO and MD.

www.yahoo.com

 

[badger2]

Trump’s REGN-COV2 was added to the RECOVERY Trial in Sep 2020. Already shown were pathologies linked to the RECOVERY Trial in post 1,027.
https://www.usmessage board.com/threads/snake-meat-source-of-chinese-virus.802608/page-52#post-25539892

REGN-COV2

Casirivimab/imdevimab - Wikipedia

en.wikipedia.org

RECOVERY Trial

RECOVERY Trial - Wikipedia

en.wikipedia.org

Trump was also taking zinc, which links Zelenko’s tripartite protocol, not simply Raoult’s protocol, which was only the duo, hydroxychloroquine and Azithromycin.

 

[badger2]

Snake Meat......source of chinese virus

We link anti-inflammatory activity of baricitinib use in COVID-19 therapy to the plant genus, Salvia. Like chloroquine and hydroxychloroquine, baricitinib is used in lupus (CLE & SLE) treatment. 14 Sep 2020 Baricitinib / Anti-Inflammatory...

www.usmessageboard.com