Godboy
Diamond Member
- Dec 29, 2008
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I just read his posts, so yeah. We also know for a fact that you have no objective reply.
Snake Meat......source of chinese virus
- Thread starter MacTheKnife
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Our "replying to oneself" was actually to get the info onto the net. Now, due to the plethora of COVID-19 threads, we can direct people to this USMB thread for further reading of the material, especially the report from Wuhan/Los/Alamos/U of C for potential reservoirs in nature, Chrysemys and Pelodiscus. This thread will remain objective and scientific while citing the authors, regardless of other reactionary postings.
In this article, readers can see the top antiviral compound docking in the COVID-19 pocket:
Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds
online.wiliey.com/doi/abs/10.1--2/minf.2000028
'Fig. 3 a) Predicted Binding Pose of our top hit compound (shown in magenta sticks) in the SARS-CoV-2 pocket....Our DD screening identified 585 new scaffolds for SARS-CoV-2 that are not shared with known protease inhibitors, although they can establish all the critical interactions with the protease active site, thus providing a completely new set of chemicals for testing and optimization.'
Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. - PubMed - NCBI
'Other than pangolins and snakes, as previously suggested, turtles (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis) may act as potential intermediate hosts transmitting SARS-CoV-2 to humans.'
Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3 Billion Compounds
online.wiliey.com/doi/abs/10.1--2/minf.2000028
'Fig. 3 a) Predicted Binding Pose of our top hit compound (shown in magenta sticks) in the SARS-CoV-2 pocket....Our DD screening identified 585 new scaffolds for SARS-CoV-2 that are not shared with known protease inhibitors, although they can establish all the critical interactions with the protease active site, thus providing a completely new set of chemicals for testing and optimization.'
Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. - PubMed - NCBI
'Other than pangolins and snakes, as previously suggested, turtles (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis) may act as potential intermediate hosts transmitting SARS-CoV-2 to humans.'
We think that the antiviral trajectory is important one to follow in conjunction with the vaccine trajectory, the latter taking more time to FDA approval. By including important genetic links to potential reservoirs and vectors of COVID-19 especially inside North America, insight into Thai use of HIV antiviral therapy will link to post # 605 for the docking of COVID19 protease inhibitors.
We also wish to invite new visitors to USMB and to this thread, as well as the Music Forum thread, Evolution of the Saxophone, where readers can hear the sound of the COVID-19 genome (if they accept the science-based protocol on which that amino acid music is based).
The latest cases in Beijing implicate pangolins.
'....15 Jun 2020 'Our preliminary assessment is the virus came from overseas. We still can't determine how it got here. It might've been on contaminated seafood or meat, or spread from the faeces of people inside the market," state media quoted Yang Peng as saying. PromedMail would like to thank Daniel Lucy, M.D., for alerting us to this outbreak yesterday (13 Jun 2020). Media reports at the time mentioned that positive environmental samples included cutting boards used for cutting imported salmon from Europe (reportedly from Norway and Denmark's Faroe Islands)....Other media reports have mentioned that pangolins were sold in the market, as one of the suspected intermediate hosts (but nor proven) and how the Jingshen Seafood Market has a history of selling pangolins. Submitted and translated by ProMed rapporteur Dan Silver
....'
Protecting Global Health, One Alert at a Time | ProMED
ProMED: Your 24/7 early warning system for emerging infectious diseases worldwide. Subscribe now to search alerts.
promedmail.org
....'
Recent Developments in Chinese Culinary Promiscuity
Should the World Be Worried?
www.yahoo.com
Should the World Be Worried?
Should the World Be Worried About the 'Explosive' New Outbreak of Coronavirus in Beijing?
Since 106 new cases emerged around a food market, the Chinese capital has been plunged into what officials are calling “wartime mode.”
Here we attempt to reinforce the potential COVID-19 seafood link to dexamethasone:
Dexamethasone Hyperresponsiveness / Parainfluenza Virus
A potential investigative trajectory is parainfluenza virus-infected sea lice of oarfish.
Next we bring up salmon androsterone due to the cutting boards being contaminated:
A functional and structural androsterone analogue is methylcyclohexanone, which is a pheromone of the most destructive forest insect in North America, the bark beetle, Dendroctonus ponderosae. Next we link two viruses to cyclohexanone. One of them is the respiratory link, the other is the link to Thai anti-HIV meds.
Cyclohexanone Newcastle Disease Virus
Cyclohexanone HIV-1 Integrase
Next we include a porcine link, recalling the German study posted in this thread that showed a porcine intestinal coronavirus subsisting on steel surfaces for up to 24 days:
Pig Testicular 20beta-hydroxysteroid Dehydrogenase / 2-Methylcyclohexanone
Dexamethasone Hyperresponsiveness / Parainfluenza Virus
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www.ncbi.nlm.nih.gov
A potential investigative trajectory is parainfluenza virus-infected sea lice of oarfish.
Next we bring up salmon androsterone due to the cutting boards being contaminated:
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www.ncbi.nlm.nih.gov
A functional and structural androsterone analogue is methylcyclohexanone, which is a pheromone of the most destructive forest insect in North America, the bark beetle, Dendroctonus ponderosae. Next we link two viruses to cyclohexanone. One of them is the respiratory link, the other is the link to Thai anti-HIV meds.
Cyclohexanone Newcastle Disease Virus
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www.ncbi.nlm.nih.gov
Cyclohexanone HIV-1 Integrase
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www.ncbi.nlm.nih.gov
Next we include a porcine link, recalling the German study posted in this thread that showed a porcine intestinal coronavirus subsisting on steel surfaces for up to 24 days:
Pig Testicular 20beta-hydroxysteroid Dehydrogenase / 2-Methylcyclohexanone
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www.ncbi.nlm.nih.gov
USMB British thread for COVID-19/dexamethasone does not mention that Newcastle virus came from Newcastle-upon-Tyne in 1927.
Virulent Newcastle Disease
en.wikipedia.org
Isopeptidases are a class of cysteine proteases, the latter having already been mentioned in this thread. Here we link cyclohexanone to isopeptidase inhibition:
Feb 2018 Isopeptidase Inhibition Based on the Bis (Arylidene) Cyclohexanone Scaffold
Virulent Newcastle Disease
Virulent Newcastle disease - Wikipedia
Isopeptidases are a class of cysteine proteases, the latter having already been mentioned in this thread. Here we link cyclohexanone to isopeptidase inhibition:
Feb 2018 Isopeptidase Inhibition Based on the Bis (Arylidene) Cyclohexanone Scaffold
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At thePubmed page for the "Binding Landscape" article above, there is a section titled "Similar Articles." The first entry is "Synthesis, Characterization, and Optimization for In Vivo Delivery of a Nonselective Isopeptidase Inhibitor As a New Antineoplastic Agent."
Therefore, the pig/bark beetle assemblage is on a correct investigative trajectory for COVID-19.
Jun 2020 Dexamethasone / COVID-19 / Oncology
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Therefore, the pig/bark beetle assemblage is on a correct investigative trajectory for COVID-19.
Jun 2020 Dexamethasone / COVID-19 / Oncology
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CrusaderFrank
Diamond Member
- May 20, 2009
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Thanks, Obama!
The Beijing cutting board contamination was from salmon of Norway, Denmark or the Faroe Islands.
Sea Lice / Salmon Farms, Faroe Islands
Jan 2019 Lepeophtheirus salmonis (Kroeyer 1837) / Infectious Salmon Anemia Virus
Salmon Lice / IHNV
'....mechanical rather than a biological vector or reservoir.'
Dexamethasone / Atlantic Salmon
Dexamethasone / Salmo / Gyrodactylus
'....mucous cell discharge elicited by infection is inhibited by the drug.'
Dexamethasone / Myeloma
Covid-19 / Myeloma
Sea Lice / Salmon Farms, Faroe Islands
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www.ncbi.nlm.nih.gov
Jan 2019 Lepeophtheirus salmonis (Kroeyer 1837) / Infectious Salmon Anemia Virus
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www.ncbi.nlm.nih.gov
Salmon Lice / IHNV
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www.ncbi.nlm.nih.gov
Dexamethasone / Atlantic Salmon
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www.ncbi.nlm.nih.gov
Dexamethasone / Salmo / Gyrodactylus
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www.ncbi.nlm.nih.gov
Dexamethasone / Myeloma
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Covid-19 / Myeloma
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PubMed shows 3 entries for coronavirus and isopeptidase, we have already mentioned mouse hepatitis virus early on in the thread.
MHV
MHV
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www.ncbi.nlm.nih.gov
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AsiaOne states that more than 1200 flights have been cancelled. Another headline states "Coronavirus: China Halts Salmon Imports Over Possible Link to Beijing Outbreak."
17 Jun 2020 Danish Mink Face Cull After Catching Coronavirus
17 Jun 2020 Danish Mink Face Cull After Catching Coronavirus
The isopeptidase article of post #614 also states: 'UB or UBL fused to the reporter enzyme phospholipase A(2) (pla(2))….ubiquitin-like protein isopeptidase activities.'
PubMed search 'covid-19 phospholipase A2' yields no references, 'covid-19 phospholipase' makes the chloroquine connection;
May 2020 Chloroquine / Phospholipase
PubMed search 'covid-19 phospholipase A2' yields no references, 'covid-19 phospholipase' makes the chloroquine connection;
May 2020 Chloroquine / Phospholipase
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Congress should absolutely ask that the war spending be detailed apart from other items.- Started by berg80
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