Cancer Cures

[badger2]

One chemical that surely links to the video of post #1 is cannabiscitrin from Cannabis indica. Here we see the Chinese struggle with the perpetual problematic of identifying active components from hundreds of others:

Cannabiscitrin / Astragalus Seed
Semen Astragali Complanati: an ethnopharmacological, phytochemical and pharmacological review. - PubMed - NCBI
'However, most of the previous studies have shown the effects brought by the total flavonoid fraction extracted from SAR only; further studies are warranted for the biological effects produced by individual components.'

In this study, they are working with the Ben Cao Can Mu Jing, China's oldest herbal, though they produce the chemical structure of cannabiscitrin, they fail to tell the people that cannabiscitrin C21H20O13 is also Myricetin 3'O-glucoside, which links to Viola Myricetin 3-rutinoside-7-rhamnoside, as Myricetin 2,3'--diglucoside in Picea abies (Pinaceae) links important lichens to an important tree against French sailor's scurvy (Labrador), and that same vitamin C which arrests cancer.

 

[badger2]

Cannaflavin A / Cannabis sativa Tinctures
Quality Control of Traditional Cannabis Tinctures: Pattern, Markers, and Stability. - PubMed - NCBI

' 277. Cannaflavin A C26H28O6 6-Geranyl-5,7,4;-trihydroxy-3'-methoxyflavone from C. sativa.

279. Rubraflavone C C30H34O6 3-Geranyl-5,7,2'4'-tetrahydroxy-6-prenylflavone from Morus rubra.'
(Handbook of Natural Flavonoids)

Not only does Morus rubra chemistry link to anti-hepatitis B virus deoxynojirimycin from mulberry tree, but also the geranyl moiety in these compounds links to anti-tuberculosis pelargonidin and the Dr. Taylor (UK) story already posted to this thread as well as the mechanism of geranylation mentioned previously. The question is what the geranyl moiety does in the lungs of the cannabis smoker. Is it destroyed more by smoke, less by vaping or dabbing? Or would it actually make physical contact with Mycobacterium tuberculosis?

 

[badger2]

The Dr. Taylor story was likely mentioned in the tuberculosis thread.

 

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'Aliphatic, i.e. open chained diterpenoids have been reviewed by Asakawa (1982). The presence of free phytol reported for a number of bryophytes, may be contentious since the ester is necessarily ubiquitous in the chlorophyll of all terrestrial green plants. The chemical treatment of the collected plant material is important as the hydrolysis of originally esterified phytol is very easily achieved by enzymatic and/or chemical reaction. The presence of its hexadehydro-derivative, i.e. geranyl geraniol in spores of Polytrichum commune is more remarkable (Liljenberg and Karunen, 1978). This compound represents, in fact, the hydrolysed precursor of all diterpenoids, geranyl geranyl pyrophosphate. Of particular note is the presence of the rare isophytol in Marchantia paleacea var. diptera (Nagai et al, 1978).'
(Bryophytes: Their Chemistry and Chemical Taxonomy)

 

[badger2]

'Beckwith-Wiedemann syndrome (BWS) (OMIM 130650) is a disorder of prenatal overgrowth, birth defects, and predisposition to cancer, and therefore of great interest in understanding embryogenesis and malignancy....Imprinted genes are often marked by differential DNA methylation of the two parental alleles....Abnormal methylation of the normally unmethylated maternal allele of a "differentially methylated region" (DMR) upstream of H19; this aberrant methylation is the likely mechanism of loss of imprinting(LOI) of IGF2.'
(Epstein, Inborn Errors of Development)

 

[badger2]

The lignans of endangered American Bay Star Vine (Schisandra), if any publication exists, would link to the bryophyte-BWS trajectory:

'The question of whether lignan occurs in bryophytes is still not fully resolved. Although polyphenolic, lignin-like materials have been reported from mosses and liverworts, most of the evidence suggests differences from higher plant lignin, especially in the degree of methylation. 2.3'-diacetoxy-5-formyl-3.4', 6-trihydroxy-2'-methoxy-6'-methyldiphenyl ether has been isolated from Trocholejeunea sanvicensis by Asakawa (1984), and 3-methyl-6, 8-dihydroxy-7-(dihydrocinnamoyl)-2H, 5H-1-benzoxepin from Radula variabilis (Asakawa et al, 1978). The polyaromatic sphagnorubins such as sphagnorubin A are associated with the cell walls of Sphagnum spp.

Chemical Synthesis of Bibenzyl Derivatives

Synthesis of simple bibenzyls from compounds with one benzene ring can be accomplished by a number of route.'
(Bryophytes, op cit)

The benzyl moiety for the Australian Aboriginal tree used against tongue cancer, Codonocarpus, has already been mentioned in this thread.

 

[badger2]

We link Tony Yu's DSRCT (post #269) to Beckwith-Wiedemann syndrome due to IGF and Zoanthus:

1.) DSRCT / IGF inks:

A putative link between exocytosis and tumor development. - PubMed - NCBI

Transcriptional and epigenetic control of IGF1R gene expression: implications in metabolism and cancer. - PubMed - NCBI

2.) 'Genomic imprinting is a parent of origin-specific mark in the gamete....'
(Epstein, Inborn Errors of Development, Beckwith-Wiedemann, p.955)

We link the DSRCT investigations to Japanese Zoanthus gigantis gametes, because they are released at extremely low tide. This links to the original description of BWS as EMG syndrome: "exomphalos, macroglossia, and gigantism. Perhaps there are as-yet unknown circadian genes linked to DSRCT as they are linked to Zoanthus.

 

[badger2]

DSRCT links IGF-1 as we have shown. Beckwith-Wiedemann links IGF2.

Circadian Clock / IGF1
Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation. - PubMed - NCBI

'....insulin-like growth fact 2 (IGF2)....long intronic transcript (LIT1), an antisense RNA, linked to overgrowth and midline abdominal wall defects....'
(Epstein, Beckwith-Wiedemann, p. 955)

DSRCT / NUT Midline Carcinomas
PHOX2B reliably distinguishes neuroblastoma among small round blue cell tumors. - PubMed - NCBI

 

[badger2]

In post #338, we linked Cannabis and herbimycin. Post #347 links exocytosis/BAIP3 gene in DSRCT. Brain-specific angiogenesis inhibitor (BAI protein) links to herbimycin:

'11152. Herbimycin C30H42N2O9, antineoplastic angiostatic antibiotic from Streptomyces hygroscopicus.'
(Organic-Chemical Drugs and Their Synonyms)

 

[badger2]

You'd Think It Was A Chinese Phenomenon

Native Celastrus scandens has gotten no modern attention for cancer:

PubMed search, 'celastrus[AND]scandens[AND]cancer', yields no references.

PubMed search 'celastrus[AND]cancer' yields almost all Chinese entries:
https://www.nlm.nih.gov/pubmed/?term=celastrus[AND]cancer

 

[badger2]

celastrus[AND]cancer - PubMed - NCBI

 

[badger2]

PubMed search 'celastrus[AND]scandens' includes a lonely Polish holdout:

celastrus[AND]scandens - PubMed - NCBI

 

[badger2]

When American prisoners attempt to read the Polish article to find out some chemistry, there is no access.

Chinese Celastrus orbiculatus / Lonicera maakii Co-Invaded Ecosystems
Co-occurring nonnative woody shrubs have additive and non-additive soil legacies. - PubMed - NCBI
'....both species are associated with altered soil properties....altering soil biotic communities....native herbaceous species can have lower arbuscular mycorrhizal fungi root colonization in soils conditioned by Lonicera maakii, and a congenr of L. sinense, suggesting that these invasive shrubs have weaker associations with mycorrhizal fungal species that are important for native plant growth....plants collected at Knoxville, Tennessee, Fall 2012, Maloney Road Park....'

Celastrus orbiculatus
Plants Profile for Celastrus orbiculatus (Oriental bittersweet)

 

[badger2]

Celastrus scandens
Plants Profile for Celastrus scandens (American bittersweet)

 

[badger2]

You'd Think It Was A Chinese Phenomenon

'Celastrus scandens.

Chippewa: boiled roots used as an ointment for cancer or any obstinate sore; decoction of stalk applied to skin "eruptions."
(Densmore F, Uses of Plants by the Chippewa Indians)

Cherokee: used as a wash for "foul ulcers."
(Hamel and Chilotsky, Cherokee Plants)

'There are several important points about this group of compounds; (a) that these alkaloids are limited in distribution to the Celastraceaem (b) there are no other groups of sesquiterpines which contain such highly oxygenated skeletal. Even the stereochemistries of some of the parent alcohols have some interesting features. The C-4 methyl group is always axial and with few exceptions the C1, C2, C3 and C6 hydroxyl groups are equatorial, axial, and equatorial, respectively. Very little biosynthetic information is available, although the pyridine ring is derived from nicotinic acid. The biosynthesis of the five-carbon side chain on the nicotinic acid residue is unknown.'
(Cordell GA, Introduction to Alkaloids: A Biogenetic Approach, p. 865)

 

[badger2]

Celapanine C30H35NO10, is from Celastrus paniculatus. Celapanigine C32H37NO9 is also from C. paniculatus:

Celastrus paniculatus / Aluminum / Decelerator of Alzheimer's
Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastrus paniculatus seed oil: Neurobehavioural, biochemical, histol... - PubMed - NCBI

 

[badger2]

We noticed increasing numbers of hydrogens in the chemical formulas as we went along. How high do they go? In Dictionary of Alkaloids, the index stops at Palytoxin C129H223N3O54. Here we link palytoxin to Zoanthus, already mentioned:

'P-00029. Palytoxin, produced by Palythoa tuberculosa and P. toxica. Structure shown is for palytoxin from a Tahitian Palythoa species. Palytoxins from P. toxica have slightly different structures. Highly toxic. LD50 is 62.5 ng/kg (crab).

P-00030. Palyzoanthoxanthin C14H16N6 pigment from Zoanthus pacificus, Palythoa mammilosa, P.tuberculosa.'
(Dictionary of Alkaloids Chapman and Hall)

We do not find any published connections to this assemblage that links DSRCT, as we have shown.

One DSRCT link for the UK is here:

Kate Granger
gttps://en.wikipedia.org/wiki/Kate_Granger

Apart from connections to pigment cell cancers, we note a staining discrepancy for DSRCT that may be of value:

DSRCT
https://en.wikipedia.org/wiki/Desmoplastic_small_cell-tumor
'....reference #4: "....Five intra-abdominal small round cell tumors showed nuclear staining for WT-1 C-terminal, but not for the N-terminal antibody....resulting in atypical staining patterns....'


Thus, a pigments-and-stains trajectory should yield more about the genes already shown that link Zoanthus to DSRCT.

 

[badger2]

If palytoxin can shut down ion channels in the cell, where are the studies published that link it to CRSPR/Cas-9 for precision targeting of cancer cells such as DSRCT?

Palytoxin
Palytoxin, the World's Second Deadliest Poison, Possibly Available at Your LFS

 

[badger2]

We add Chionanthus to this thread not only because it links to the Emerald Ash Borer, but because it may also link to Marburg virus due to African Buprestids and the parasites in dogs at Bulawayu, precisely where the Australian hitch-hiker infected with Marburg virus took a photograph during his tourism.

'Chionanthus virginicus L. Grey Beard Root. Decoction for cancer, Georgia, 1959, National Cancer Institute central files.'
(Hartwell, Plants Used Against Cancer)

 

[badger2]

The problem is that the reader must subscribe to read the article. This is the trend: books disappear from three dimensions, while pay-for cyberspace-as-drug.adopts the prisoner to the absurdity.

MCF Breast Cancer Cells / Water Quality Testing
Benchmarking Water Quality from Wastewater to Drinking Waters Using Reduced Transcriptome of Human Cells. - PubMed - NCBI