Probably one of the great proofs of the fakeness of professional wrestling.
In a fictional context, giants make for great monsters, bigger and mightier than normal people.
In reality, the human body only really works well within a certain size range, and when you get beyond that range, it doesn't work all that well at all. In a fair fight, a man of normal size, and reasonable robustness, could probably kick the ass of a giant like André. Giants usually have some degree of physical disability, along with health problems and short lifespans. André only lived to the age of 46.
It professional wrestling was real, I don't think that André the Giant could have been at all successful at it. At his size, he was probably too close to collapsing under his own weight, to be able to function with someone intentionally trying to collapse him.
The tallest man known to have ever lived, Robert Wadlow, only lived to the age of 29 years. He had to wear braces to support his legs, because they weren't strong enough to support his full weight normally. At the time of his death, he was less than an inch short of nine feet tall.
By similar principles, if you could scale an insect up to the side of a human, it would collapse under its own weight. The way insects are structured works well in that size range, but not for anything very much bigger. It takes different kinds of structure for a living organism to exist at different sizes. An elephant is build differently than a horse, which is built differently than a human, which is built differently than an ant, which is built differently than a rotifer.