Silhouette
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- Jul 15, 2013
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The Hunt for Effective Anticancer Vaccines
6 whole participants while other countries are diving in? You're all heart BigPharma USA!
The team theorized that, because of the similarities between embryonic cells and tumor cells, the body might be coaxed into an immunogenic anticancer response by introducing induced pluripotent stem (iPS) cells.
They used blood samples from the mice to create genetically matching iPS cells, irradiated the iPS cells to prevent proliferation and teratomas, and injected them into a group of mice once a week for 4 weeks. One group of mice received the iPS cells alone. Another received the cells plus the adjuvant CpG, a known immune-stimulating agent. A third group received CpG alone. Then they transplanted a mouse breast cancer line into the test animals. A fourth received a control solution.
....while they grew robustly in the various control groups, they shrank in 7 of the 10 mice given the combination of iPS cells and CpG. Two completely rejected the tumor cells and lived cancer-free for more than a year after transplantation.
******
So the way I understand it is, they use the patient's particular cancer's dna to train up the T-cells to recognize and destroy the cancer. Recognition and destruction are the key because it disguises itself so the body just thinks everything is OK as the cancer grows unchecked.
Before this gets slammed into health forum, let the masses who visit "Current Events" have a shot at reading it and discussing it? Sort of like the moderators' contribution to saving lives as the word spreads?
I lost several family members and friends to cancer. They would've liked to have known about this awhile back. However, vaccines and how they work have been known about for some time. With viruses, they used a modified live virus often, one that isn't deadly but is so close that it trains the immune system to attack the real deal. Also they use killed virus with similar effects of recognition. Seems someone's thinking cap could've been on a long time ago about this one.
True they have to sample tumors from each individual patient because of the wide variation in mutated dna intrinsic to each type of cancer and patient in which it sits. But I think they could streamline the process and get 'er done. It might cut into chemo $$ though. Might be the reason the US is dragging ass.
Discuss.
The American study involved only 6 participants with previously untreated melanoma, but, the authors wrote, “4 had no recurrence at 25 months after vaccination, while two with recurrent disease were subsequently treated with anti-PD-1 (anti-programmed cell death-1) therapy and experienced complete tumour regression, with expansion of the repertoire of neoantigen-specific T cells.”1
6 whole participants while other countries are diving in? You're all heart BigPharma USA!
The German team also used exome sequencing to develop personalized vaccines for 13 patients with melanoma. But they used RNA molecules to deliver the vaccine and trigger the participants' immune systems. Nine of the participants, 8 given just the vaccine and 1 given the vaccine plus a checkpoint inhibitor, remained cancer-free 12 to 23 months later.
They realized, however, that “the vast majority of mutations are unique to the individual patient. Hence, mutanome vaccines need to be individually tailored and rapidly manufactured on-demand.”
The team theorized that, because of the similarities between embryonic cells and tumor cells, the body might be coaxed into an immunogenic anticancer response by introducing induced pluripotent stem (iPS) cells.
They used blood samples from the mice to create genetically matching iPS cells, irradiated the iPS cells to prevent proliferation and teratomas, and injected them into a group of mice once a week for 4 weeks. One group of mice received the iPS cells alone. Another received the cells plus the adjuvant CpG, a known immune-stimulating agent. A third group received CpG alone. Then they transplanted a mouse breast cancer line into the test animals. A fourth received a control solution.
....while they grew robustly in the various control groups, they shrank in 7 of the 10 mice given the combination of iPS cells and CpG. Two completely rejected the tumor cells and lived cancer-free for more than a year after transplantation.
******
So the way I understand it is, they use the patient's particular cancer's dna to train up the T-cells to recognize and destroy the cancer. Recognition and destruction are the key because it disguises itself so the body just thinks everything is OK as the cancer grows unchecked.
Before this gets slammed into health forum, let the masses who visit "Current Events" have a shot at reading it and discussing it? Sort of like the moderators' contribution to saving lives as the word spreads?
I lost several family members and friends to cancer. They would've liked to have known about this awhile back. However, vaccines and how they work have been known about for some time. With viruses, they used a modified live virus often, one that isn't deadly but is so close that it trains the immune system to attack the real deal. Also they use killed virus with similar effects of recognition. Seems someone's thinking cap could've been on a long time ago about this one.
True they have to sample tumors from each individual patient because of the wide variation in mutated dna intrinsic to each type of cancer and patient in which it sits. But I think they could streamline the process and get 'er done. It might cut into chemo $$ though. Might be the reason the US is dragging ass.
Discuss.