'....Low-income households were more likely to be at risk than those in higher-income households, as were those residing with black children; adults living with Asian children or children of other races/ethnicities were at lowest risk.'
The combination of COVID-19 and riots is taking a toll on downtown Portland's business base, and one of the city's major employers, Standard Insurance, is not being quiet about it.
finance.yahoo.com
'....There was damage to a lobby where protective equipment against the spread of the coronavirus is distributed.'
Mexico will receive at least 2,000 doses of Russia’s candidate coronavirus vaccine as part of the injection's Phase 3 clinical trials, Mexico’s foreign minister said Thursday.
www.themoscowtimes.com
'....The Latin American country is also readying to conduct late-stage trials of the COVID-19 vaccine of Johnson & Johnson and two Chinese companies.'
One theory is that prior exposure to other viruses may help fight off the novel coronavirus. There are four other, far less deadly coronaviruses which cause the common cold. Earlier this summer, researchers from La Jolla Institute for Immunology published new findings in the journal Cell...
www.yahoo.com
'....There is a huge variation in our genes in the human population....Everyone is genetically different. You can find kids who get respiratory infections 10 to 12 times a year, totally atypical, and when you look at their genome, you find that they have mutations that make them more susceptible.'
Once again, Trump (and his advisors) are correct: hydroxychloroquine works. Three C-19 meds, one also approved in Japan (favilavir) have been recommended:
The corona virus transmits quicker than its two predecessors the MERS-CoV and SARS-CoV, but has reduced casualty. The global effects of this latest pandemic are still unclear. Nevertheless, considering that so far no vaccine has been available; preventive approaches are the best way to fight...
www.ncbi.nlm.nih.gov
'....The Ministry of Science and Technology in the People's Republic of China declared three potential anti-viral medicines suitable for treating COVID-19. Those three are, namely, favilavir, chloroquine phosphate, and remdesivir. Hydroxychloroquine combined with azithromycin enhances the reduction of the viral load in COVID-19 patients.'
Favilavir (post #945) aka favipiravir, is a prodrug activated by human metabolism, a key enzyme being hypoxanthine guanine ribosyltransferase (HGPRT). We thank Australia for keeping an eye on vaccinations in the region, especially covert COVID-19 vaccinations.
23 Aug 2020 Coronavirus: Chinese Mining Company Tests Vaccine on Papua New Guinea Workers Without Country's Permission
'....Phone calls to Ramu's office in the Papua New Guinea city of Madang and the parent company's Beijing headquarters were not answered on Friday....The vaccine could cause false-positive test results in those who received it.'
The report mentions that it was Chinese workers who were vaccinated. However, there is more to the story than meets the eye. Firstly, we link the lack of the enzyme, HGPRT, to Lesch-Nyhan syndrome:
'....similar to those seen in Huntington's disease....inherited in an X-linked recessive manner....carrier females are generally an asymptomatic condition....the overwhelming majority of LNS patients are male.'
The Lesch-Nyhan syndrome links to kuru via the symptom of
choreoathetosis:
Complete deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity causes Lesch Nyhan disease (LND), characterized by hyperuricemia, severe action dystonia, choreoathetosis, ballismus, cognitive and attention deficit and self-injurious behavior. Partial HPRT deficiency is...
www.ncbi.nlm.nih.gov
It was Gajdusek, writing on kuru in the Fore people of New Guinea, who photographed and documented athetoid movements in Yakurimba, a young male suffering from kuru. Next, we note the distance on maps from Madang to the Fore area:
Thus, COVID-19-vaccinated Chinese workers just miles from where the lack of the enzyme, HGPRT, that causes athetoid symptoms link to the athetoid symptoms of kuru. How would the Chinese benefit from such an arrangement?
President Donald Trump on Sunday announced emergency authorization to treat COVID-19 patients with convalescent plasma — a move he called “a breakthrough,” one of his top health officials called “promising” and other health experts said needs more study before it's celebrated. The announcement...
Papua New Guinea blocked the arrival of a flight carrying workers from China after a Chinese mine operator said its employees were given a coronavirus vaccine in a possible unauthorized trial, authorities said Friday. The Pacific nation's pandemic response controller, David Manning, banned...
news.yahoo.com
'....A Chinese company is testing a vaccine on volunteers in Indonesia.'
Linking kuru in New Guinea to the essential anti-COVID-19 agent, ...favipiravir and its target enzyme (hypoxanthine guanine phosphoribosyltransferase [HGPRT]), a Pubmed search 'hypoxanthine guanine prion' yields 6 references, one of which is this Mohave report (recalling the 'slow viruses' of Gajdusek, et al) the patient was treated with ganciclovir:
An infectious illness, attributed to atypically structured cytopathic "stealth" viruses, occurred in 1996 in the Mohave Valley region of the United States. A stealth virus-infected child from this region has developed a severe noninflammatory, vacuolating (spongiform) en cephalopathy. The...
'....These procedures are outlined below with regard to our targeting of subtle alterations into the prion protein gene, a gene whose product, PrPc, is involved intimately in the transmissible spongiform encephalopathies.'
Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) are the foremost causative agents of malaria. Due to the development of resistance to current antimalarial medications, new drugs for this parasitic disease need to be discovered. The activity of...
www.ncbi.nlm.nih.gov
The Chinese report in this thread for Neophocaena link poterntial COVID-19 intermediate hosts, including Bovidae.
Pubmed search 'cetacea prion' yields 8 references, and one of them from Bologna, Italy (2007), costs $35.95 to view:
The partial PrP gene sequence and the deduced protein of eight cetacean species, seven of which have never been reported so far, have been determined in order to extend knowledge of sequence variability of the PrP genes in different species and to aid in speculation on cetacean susceptibility to...
Long non-coding RNAs (lncRNA) and microRNAs (miRNAs) are a subject of active investigation in neurodegenerative disorders including Parkinson's disease (PD). We hypothesized a regulatory role of lncRNA H19 with involvement of hypoxanthine phosphoribosyltransferase 1 (HPRT1) in dopaminergic...
www.ncbi.nlm.nih.gov
'....treatment with lentiviral oe-HPRT1, agomir-mir-301b-3P and inhibition of the wnt/beta-catenin pathway.'
Alabama and Poland: SARS-CoV-2 May Regulate Cellular Responses Through Depletion of Specific Host miRNAs, Lung Cellular and Molecular Physiology, 5 Aug 2020
'....As shown in Table 1, COVID-19-mediated decrease of host mir-34a-3P and mir-495-5P levels could increase XBP1s and BiP expression, respectively, by increasing the ER (endoplasmic reticulum) folding capacity and promoting survival. Through mir-376b-3P, the virus could also potentially modulate the mTOR and autophagy pathways.'
Thusfar, it is unknown whether there have been any COVID-19 cases amongst the Fore people, though vaccinated Chinese in proximity to them is indeed peculiar.
Recalling from the literature the two Chinese physicians who wagered on the gender of the forthcoming child of a female who received accupuncture to two specific points on her leg, mir-34a-3p that links to COVID-19 (previous post) also links to abortion:
This study suggests that miR-34a-3p/5p, miR-141-3p/5p, and miR-24 in decidual NK cells could be associated with URSA. These findings might contribute to the panel of diagnostic and prognostic biomarkers with clinical utility, and facilitate the development of new strategies for targeted therapy...
MicroRNA (miR)-34a was recently determined to contribute to the pathological development of Alzheimer's disease (AD). miR-34a deficiency significantly attenuates cognitive deficits in amyloid precursor protein (APP)/presenilin 1 (PS1) mice; however, its role in early AD pathology and the...
Prion diseases are a group of fatal neurodegenerative disorders that affect humans and animals. Besides of the pathological agent, prion, there are some elements that can influence or determine susceptibility to prion infection and the clinical phenotype of the diseases, e.g., the polymorphism...
These results indicate that SNP rs2910164 G > C is associated with increased odds for P. falciparum infection in first-time pregnant women who are considered to lack sufficient acquired immune responses against pregnancy-specific strains of P. falciparum. These findings suggest that miRNA-146a is …
www.ncbi.nlm.nih.gov
Mirna-146a links to COVID-19 via 14-3-3 csf protein:
SARS-CoV-2 is the etiologic agent of COVID-19. There is currently no effective means of preventing infections by SARS-CoV-2, except through restriction of population movement and contact. An understanding of the origin, evolution and biochemistry (molecular biology) of SARS-CoV-2 is a...
www.ncbi.nlm.nih.gov
'....all located in a stretch that forms a phosphorylation dependent interaction site, including C-TAK1 phosphorylation sites for 14-3-3....is a cellular response mechanism for the control and inhibition of the replication, transcription and packaging of the SARS-CoV-2 genome.'
We will take a bit closer look at these anti-COVID-19 candidates. Not surprisingly, hydroxychloroquine and chloroquine are left off the list, which is less science and more the desperation/coercion of economic politics.
'....In Ap 2020, a whistleblower complaint by former Head of U.S. Biomedical Advanced Research and Development Authority (BARDA) Rick Bright suggested he had been removed from his position over raising concerns over providing funding for the further development of MK-4482 due to similar drugs having mutagenic properties (producing birth defects). A previous company, Pharmasset, that had investigated the drug's active ingredient had abandoned it.'
'....EIDD-2801 works similarly to Gilead Sciences' remdesivir, an unapproved drug, that was developed for ebola virus....But remdesivir can only be given intravenously, meaning it would be difficult to develop widely....EIDD-2801 was able to overcome the coronavirus proofreading function. Unlike remdesivir, EIDD-2801 lacks human safety data.'
However, Trump et al's hydroxychloroquine also blocks COVID-19(SARS-CoV-2) proofreading. One can view the hydroxyls (OH groups) of MK-4482 on the wiki page, though the idea was originally hydroxychloroquine's, because the addition of the hydroxyl group rendered hcq safer than cq.
14 Aug 2020 Proofreading Hydroxychloroquine/Chloroquine
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a severe global health crisis. In this paper, we used docking and simulation methods to identify potential targets and the mechanism of action of chloroquine (CQ) and hydroxychloroquine (HCQ) against...
www.ncbi.nlm.nih.gov
'....Furthermore, cq and hcq also influenced the proofreading and capping of viral RNA in SARS-CoV-2, performed by nsp10/nsp14 and nsp10/nsp16. In particular, hcq demonstrated a better energy binding with the examined targets compared to cq, probably due to the hydrogen bonding of the hydroxyl group of hcq with polar amino acid residues.'
So choosing the first candidate at random, one can see that there is clearly ahistorical bias in the use of MK-4482, when the actual antiviral innovation belonged to Trumps' hydroxychloroquine.
The ability to kill SARS-CoV-2 on surfaces for up to seven days is attention-grabbing, but experts say it’s unlikely to do much in stopping the spread of COVID-19.
www.yahoo.com
British military scientists have discovered a product, citriodiol, found in insect repellent that can kill a strain of COVID-19:
British military scientists have discovered that a product found in insect repellent can kill the strain of coronavirus that causes COVID-19, Sky News reported on Wednesday. The product, Citriodiol, could offer a new layer of protection against COVID-19 according to scientists at the UK's...
In this study, the monoterpenes, α-pinene and geraniol, were biotransformed to synthesize monoterpene alcohol compounds. Polyporus brumalis which is classified as a white rot fungus was used as a biocatalyst. Consequently α-terpineol was synthesized from α-pinene by P. brumalis mycelium, after...
