Snake Meat......source of chinese virus

[Crixus]

The chiinese eat all kinds of exotic foods......and live with pigs in many cases....the source of most of the flu viruses that travel around the world.

.Wuhan: Chinese scientists trace coronavirus to snakes - Breitbart

Hm. I don't think this is 100% accurate. I don't think it's the food, I think it's the cleanliness. The Chinese are just a gross people.

Upon what do you base that comment?

That Chinese folks in China are gross people? Let's begin with the wet markets. They are nothing unique. We have them here. Maybe not have, dogs, and bugs, but we have them. The difference is here we have health inspectors who make sure they are clean, and that live animals are kept humanly. China doesn't have this. And the other part I base my opinion on is how them that live here in Galveston act. They throw their trash on the beach, they are extremely racist and have no idea how to act or be good guests. Honestly, we should have let the Japanese exterminate them before we got involved in WW2.

How many wet markets have you been to in China? How many have you been in the US? How many have you been to in other countries?

In China, none, and I dont care to. Yes I have been to other "wet markets" In other countries, and I have been to many here, and I still frequent a few. Do I have an issue with cleanliness? Here, no I don't. While I may not be able to buy a black bears y'all bladder and some monkey testicles cut fresh off the monkey while I wait, I can get some pheasant, rabbit, chicken, fish and other stuff that I pick out while it's very much alive, have it clubbed over the head, cleaned, butchered and packaged, ot whole for me to deal with. Pretty much what they do in China and everyway else, except for the fact that here, health inspectors make sure the market isn't spreading shit like H1N1, or covid 19.

Your reason for denouncing over a billion people and you have never even seen one. Interesting.

One what? Chi see person? Every nasty flue comes out of that shithole. They are nothing but a third world country that got smart phones and a nuclear reactor. Nothing to them but that. You will see the quality of the people as times begin to suck over there.

 

[badger2]

Starve a Fever, Feed a Cold

The study mentions Raoult:

Nutrition and COVID-19

Symposium: Renin-angiotensin-aldosterone system and hypertension - PubMed

Symposium: Renin-angiotensin-aldosterone system and hypertension

www.ncbi.nlm.nih.gov

'....Hydroxychloroquine in combination with azithromycin has been particularly focused upon the results of a French study where 26 COVID-19 patients received the combination treatment vs. control groups. However, there were several issues with the study design, including its small sample size, the fact that the control groups were from different hospitals, the study was not blinded, and a myriad of other issues. While the study provided an indication that hydroxychloroquine was worth further investigation, its results have been blown out of proportion in the media. Hydroxychloroquine has even been prematurely touted as a "game-changer" by President Donald Trump of the United States, who has admonished that he may even consider taking this untested drug against COVID-19.
....
tbc

 

[Unkotare]

...They are nothing but a third world country that got smart phones and a nuclear reactor. Nothing to them but that. You will see the quality of the people as times begin to suck over there.

Is that the impression you were left with after all your time living there? Is that what you think of all the Chinese people you know well personally? You don't sound like a very good friend.

 

[badger2]

In the news, there is no apparent news about Russian areplivir (post #640).

Colchicine is from autumn crocus, Colchicum autumnale. The study of post #822 continues:

'Indeed, there is a focus on the anti-inflammatory drug, colchicine, which has been previously used effectively against cardiovascular disorders.
....
ACE inhibitors and angiotensin receptor blockers (ARBs)....higher level of ACE2 might increase susceptibility of cells to SARS-CoV-2 viral host entry and propagation, whereas on the other hand the activation of ACE2 may ameliorate the acute lung injury induced by SARS-CoV-2. Despite these concerns, the European Society of Cardiology recommends that patients continue their antihypertensive meds due to a lack of evidence. This may also have dietary implications due to the modulatory effects dietary patterns can have on hypertension, but also due to the fact that some foods are associated with high levels of ACE inhibitory peptides.'

The 'higher level of ACE2' mentioned above, omits an important factor which we mentioned in post #621: the amount of glycosylation of ACE2 is equally important: 'It is the amount of glycosylated ACE2 receptors, and not simply the amount of ACE2 alone that is responsible for the virus binding and fusion.'

Ethnic amounts of ACE2 receptors were mentioned on 13 Feb 2020, post 398, listed in decreasing order.

 

[badger2]

Again, we recall the proximity of the 2020 Italian COVID-19 epicenter in Lombardy to the 2007 chikungunya outbreak in the region, as we further investigate colchicine. Where these reports are failing, is precisely at the point where hydroxychloroquine differs from chloroquine:

Colchicine / Chikungunya-Induced Arthralgia

A Case of Chikungunya Virus Induced Arthralgia Responsive to Colchicine - PubMed

Chikungunya virus is an emerging infectious disease that has started circulating throughout the Americas and Caribbean. It can lead to persistent arthralgia lasting months to years. Treatment has been symptomatic with nonsteroidal anti-inflammatory medications. This case report describes a trial...

www.ncbi.nlm.nih.gov

Jul 2020 Colchicine / COVID-19 / Hydroxychloroquine

Continuous hydroxychloroquine or colchicine therapy does not prevent infection with SARS-CoV-2: Insights from a large healthcare database analysis - PubMed

These findings raise doubts regarding the protective role of these medications in the battle against SARS-CoV-2 infection.

www.ncbi.nlm.nih.gov

Aug 2020 Colchicine / COVID-19

Colchicine and COVID-19 - PubMed

Colchicine and COVID-19

www.ncbi.nlm.nih.gov

Pharmacological differences twixt hcq and cq were post in #770, and (enhanced [italics]) chikungunya is at post #682.

 

[BigDave]

Snake meat is some good eatin'

 

[badger2]

COVID-19 and Anosmia Genetics

We begin an loss of smell (anosmia) trajectory with this report:

https://www.advances.sciencemag.org/content/early/202007/24/sciadv.abc5801.1

'....Of note, only dorsally-located sustentacular cells, which express the markers Sult1c1 and ACSM4 were positive for ACE2. Indeed, reanalysis of the ACE2-positive subset of human sustentacular cells revealed that all positive cells expressed genetic markers associated with dorsal epithelium....expression was observed in a fraction of Bowman's glands cells and HBCs....activated HBCs express higher ACE2 levels than resting cells.'

We next link COVID-19 SLC6A2 to the sulfur transporter SULT1c1:

'an abnormality of the sulfate transporter, which causes diastrophic dysplasia.'
(Epstein, Inborn Errors of Development, p. 4)

Diastrophic Dysplasia / Epiphyseal Dysplasia / SLC26A2

Recessive multiple epiphyseal dysplasia - Clinical characteristics caused by rare compound heterozygous SLC26A2 genotypes - PubMed

Pathogenic sequence variants in the solute carrier family 26 member 2 (SLC26A2) gene result in lethal (achondrogenesis Ib and atelosteogenesis II) and non-lethal (diastrophic dysplasia and recessive multiple epiphyseal dysplasia, rMED) chondrodysplasias. We report on two new patients with rMED...

www.ncbi.nlm.nih.gov

SARS-CoV-2 Solute Carrier SLC6A19

SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics - PubMed

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has challenged the speed at which laboratories can discover the viral composition and study health outcomes. The small ∼30-kb ssRNA genome of coronaviruses makes them adept at cross-species spread while enabling...

www.ncbi.nlm.nih.gov

 

[badger2]

Keeping in mind that SULT1c1 is sulfotransferase in COVID-19-induced anosmia, this solute-carrier trajectory links to the epithelial cells of breast cancer:

SLCs / OATP1A2

Chloroquine and Hydroxychloroquine Are Novel Inhibitors of Human Organic Anion Transporting Polypeptide 1A2 - PubMed

Chloroquine (CQ) and hydroxychloroquine (HCQ) are widely used to treat malaria and inflammatory diseases, long-term usage of which often causes severe side effects, especially retinopathy. Solute carrier transporters (SLCs) are important proteins responsible for the cellular uptake of endogenous...

www.ncbi.nlm.nih.gov

OATP1A2 Genetic Polymorphisms

Genetic polymorphisms and function of the organic anion-transporting polypeptide 1A2 and its clinical relevance in drug disposition - PubMed

The solute carrier organic anion-transporting polypeptides (OATPs) are a family of transporter proteins that have been extensively recognized as key determinants of absorption, distribution, metabolism and excretion of various drugs because of their broad substrate specificity and wide tissue...

www.ncbi.nlm.nih.gov

'....OATP1A2 is nearly 10-fold higher in breast cancer....516 C>T (exon 5) variant showed a decreased uptake of estrone sulfate and MTX (methotrexate)....38T>C (exon 1) variant caused an isoleucine-to-threonine change, and increased uptake of estrone sulfate and MTX.'

Out of 12 shown polymorphisms in OATP1A2, four of them involve branched-chain amino acids. Recalling Aboriginal use of the tree, Codonocarpus for (apparently, though we have no access to the Australian government archives for this document) oral squamous cell carcinoma. In addition, Hegenauer's Chemotaxonomie der Pflanzen, shows particularly the (sequestering [italics]) of branched-chain amino acids as part of its biology.

 

[badger2]

Since the speculation of Cheremys as intermediate host of COVID-19 is science-based, and since Cheremys has been treated with chloroquine for helminth-caused conjunctivitis, development as an animal model for COVID-19 makes sense. The hydroxyl moiety added to chloroquine makes it more fit for human use. On the other hand, chloroquine in an animal model such as Cheremys infected with COVID-19 does not yet exist.

 

[badger2]

Next we link anoxia to solute carriers in the proposed COVID-19 intermediate host. Anoxia was mentioned in posts #596, 653, and 667.

Chrysemys / Anoxia Tolerance

Anoxia tolerance in turtles: metabolic regulation and gene expression - PubMed

Freshwater turtles of the Trachemys and Chrysemys genera are champion facultative anaerobes able to survive for several months without oxygen during winter hibernation in cold water. They have been widely used as models to identify and understand the molecular mechanisms of natural anoxia...

www.ncbi.nlm.nih.gov

'....anoxia-responsive transmembrane solute carriers.'

 

[badger2]

Previously, we pointed to a report that mentions Raoult's combination treatment for COVID-19: hydroxychloroquine and azithromycin, and the same report links antihypertensives:

COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation - PubMed

The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. As a result, there has been considerable economic distress globally and a significant loss of life. Sadly, the...

www.ncbi.nlm.nih.gov

'....ACE inhibitors and angiotensin receptor blockers (ARBs) higher levels of ACE2 might increase susceptibility of cells to SARS-CoV-2 viral host entry and propagation, whereas on the other hand the activation of ACE2 may ameliorate the acute lung injury induced by SARS-CoV-2. Despite these concerns, the European Society of Cardiology recommends that patients continue their usual antihypertensive medications due to a lack of evidence. This may also have dietary implications....'

Blumberg (NASA Astrobiology) has used iminosugar decoys (deoxynojirimycin), 9-nonyl moieties of deoxynojirimycin, and others, to prevent maturation of hepatitis B virus. Here we link hepatic SULT1 to minoxidil-mediated hypertension, to pick up hydroxy- and imino-moieties:

Induction of rat hepatic aryl sulfotransferase (SULT1A1) gene expression by triamcinolone acetonide: impact on minoxidil-mediated hypotension - PubMed

The hypotensive agent minoxidil (6-imino-1, 2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine) depends upon aryl sulfotransferase (SULT1)-catalyzed sulfation for its bioactivation. Previous reports suggest that glucocorticoids induce class-specific SULT1 and isoform-specific SULT1A1 gene...

www.ncbi.nlm.nih.gov

'....hydroxy....imino....'

Next, we find a zebrafish model for cytosolic SULT1, which links the thyroid, sexual gland par excellence:

Tyler, Texas / Zebrafish Cytosolic SULT1

cDNA cloning, expression, and functional characterization of a zebrafish SULT1 cytosolic sulfotransferase - PubMed

Using the reverse transcriptase-polymerase chain reaction technique, a full-length cDNA encoding a novel zebrafish sulfotransferase was cloned and sequenced. Sequence analysis indicated that this zebrafish sulfotransferase belongs to the SULT1 cytosolic sulfotransferase gene family. The...

www.ncbi.nlm.nih.gov

'....displayed activities toward....thyroid hormones....'

In a proposed Chrysemys-COVID-19 model, chloroquine would link insulin to the thyroid as well as Zelenko's (previous posts) zinc:

(1985) Chrysemys Thyroid / Chloroquine / Insulin

Specific uptake, dissociation, and degradation of 125I-labeled insulin in isolated turtle (Chrysemys dorbigni) thyroid glands - PubMed

Thyroid glands from turtles (Chrysemys dorbigni) pretreated with potassium iodide were incubated with 125I-insulin in the presence or absence of unlabeled insulin, in order to study its specific uptake. At 24 degrees, the specific uptake reached a plateau at 180 min of incubation. The dose of...

www.ncbi.nlm.nih.gov

'....insulin-binding sites in the turtle thyroid gland may be suggested....bacitracin and chloroquine inhibited degradation activity....Among 10 divalent metal cations tested, Hg(2+), Co(2+), Zn(2+), Cd(2+), Cu(2+), and Pb(2+) exhibited dramatic inhibitory effects on the activity of the zebrafish sulfotransferase.'

This may be compared to COVID-19 anosmia and SULT1c1 in olfactory epithelia, positive for ACE2, which is the target of this virus.

 

[badger2]

Thus, the European Society of Cardiologists mentions antihypertensives because of paucity of evidence, though simultaneously fails to mention their antiviral potentials.

The chloroquines can induce both pro- and anti-arrhythmia effects, and the procyanidins mentioned in post #688 are paramount for stabilizing human heart rhythm. Therefore, a Chrysemys model would include a regimen of procyanidins in conjunction with COVID-19 infection.

 

[badger2]

Blumberg's 9-nonyl moiety against HBV links to phytoestrogens:

2007, UK: Sulfotransferase / Sult1A1

Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption - PubMed

Some endocrine disrupting compounds such as phthalates and phenols act non-genomically by inhibiting the sulfotransferase (SULT 1E1 and SULT 1A1) isoforms which inactivate estrogens by sulfonation. A range of environmental phenolic contaminants and dietary flavonoids was tested for inhibition of...

www.ncbi.nlm.nih.gov

'....SULT 1A1....4-nonyl-phenol inhibited SULT 1E1....'

 

[badger2]

Treating COVID-19 early is key to intercepting virus control, and it's in minutes with foot-and-mouth disease virus:

(1984) Chloroquine / Foot-and-Mouth Disease

Effect of lysosomotropic agents on the foot-and-mouth disease virus replication - PubMed

The effect of two lysosomotropic agents, NH4Cl and chloroquine, on the foot-and-mouth disease virus (FMDV) replicative cycle was studied. When the drugs were present throughout the viral replicative cycle, an important inhibition of viral RNA synthesis and virus production was detected. The...

pubmed.ncbi.nlm.nih.gov

Trump's advocacy of hydroxychloroquine is basically correct, though other factors come into play with each patient.

 

[badger2]

We have linked lupus and hydroxychloroquine in post #756 of the thread. Mannose binding lectin is also linked to lupus, and we've already mentioned the recent alanine-to-glycine mutation in COVID-19 spike protein:

Copenhagen / Mannose-Binding Lectin / Lupus

The 'involution' of mannose-binding lectin - PubMed

Mannose-binding lectin (MBL) acts as a serum opsonin in innate immune defense and induces complement activation by the lectin pathway. In humans, low levels of functional serum MBL are caused by the dominant action of three single nucleotide substitutions in exon 1 that disrupt the glycine-rich...

www.ncbi.nlm.nih.gov

'....glycine-rich backbone of MBL protein....glycine residues of the collagen-like region....'

Mannose-Binding Lectin / SARS-CoV Susceptibility

Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection - PubMed

MBL gene polymorphisms were significantly associated with susceptibility to SARS-CoV infection; this might be explained by the reduced expression of functional MBL secondary to having the codon 54 variant.

www.ncbi.nlm.nih.gov

'....H/L, Y/X, P/Q variants....significantly associated with susceptibility to SARS-CoV.'

 

[badger2]

Errata: It is not an alanine-to-glycine mutation, and is an aspartic acid-to-glycine mutation (D614G), first mentioned at USMB thread "Keeping America Great Again" in post #61,134 on 2 Jul 2020. We mentioned it in post #774 of this thread on 19 Jul 2020.

Jul 2020 D614G

Could the D614G substitution in the SARS-CoV-2 spike (S) protein be associated with higher COVID-19 mortality? - PubMed

The increasing number of deaths due to the COVID-19 pandemic has raised serious global concerns. Increased testing capacity and ample intensive care availability could explain lower mortality in some countries compared to others. Nevertheless, it is also plausible that the SARS-CoV-2 mutations...

www.ncbi.nlm.nih.gov

 

[badger2]

This is the first person to receive a vaccine in phase 3:

3 hrs ago

Georgia News Anchor Becomes First Person to Receive COVID-19 Vaccine Shot in Phase 3 Trial

The Phase 3 trial is expected to recruit 30,000 volunteers who will receive two injections of either the vaccine or a placebo

www.yahoo.com

 

[badger2]

Today's report on a non-human primate COVID-19 vaccine:

https://finance.yahoo.com/news/j-j-covid-19-vaccine.000000906.html

 

[badger2]

We'll try this URL for the Johnson & Johnson vaccine:

Johnson & Johnson’s single-shot coronavirus vaccine has begun human trials

Johnson & Johnson’s experimental coronavirus vaccine entered human trials this month after an early study showed it helped protect a group of primates with a single shot.According to …

thehill.com

 

[badger2]

7 hours ago
FDA Chief: Hydroxychloroquine Use a Decision Between Doctor and Patient

FDA chief: Hydroxychloroquine use a decision between doctor and patient

Stephen Hahn, the commissioner of the Food and Drug Administration (FDA), on Thursday declined to take a definitive stance on whether people should take hydroxychloroquine as a treatment for t…

thehill.com

30 Jul 2020 Fauci Contradicts Trump

Dr. Fauci Asserts Hydroxychloroquine 'Not Effective' vs. COVID-19

Dr. Anthony Fauci debunks a renewed claim by President Donald Trump that hydroxychloroquine can cure COVID-19.

www.ibtimes.com