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We have shown that immortalization of North American bat cells used Bmi-1, including the Netherlands strain of HCoV-NL63, on a trajectory investigating COVID-19 brain autopsies. Bmi-1 also links to Tom Parker's glioblastoma:
Wanted Singer Tom Parker Reveals Inoperable Tumor
Bmi-1 Inhibits Glioblastoma
Interestingly, the Bmi-1-glioblastoma report is from Groningen, The Netherlands and Hubei Key Laboratory of Cell Homeostasis, Wuhan, China.
Wanted Singer Tom Parker Reveals Inoperable Tumor
Bmi-1 Inhibits Glioblastoma
Targeting of BMI-1 with PTC-209 inhibits glioblastoma development - PubMed
Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becomes an attractive therapeutic target. Here we showed that...
www.ncbi.nlm.nih.gov
Interestingly, the Bmi-1-glioblastoma report is from Groningen, The Netherlands and Hubei Key Laboratory of Cell Homeostasis, Wuhan, China.