COVID-19’s Biological Politics

[badger2]

We have shown that immortalization of North American bat cells used Bmi-1, including the Netherlands strain of HCoV-NL63, on a trajectory investigating COVID-19 brain autopsies. Bmi-1 also links to Tom Parker's glioblastoma:

Wanted Singer Tom Parker Reveals Inoperable Tumor

https://www.monstersandcritics.com/celebrity/the-wanted-singer-tom-parker-reveals-inoperable-brain-tumor-diagnosis-what-is-glioblastoma/

Bmi-1 Inhibits Glioblastoma

Targeting of BMI-1 with PTC-209 inhibits glioblastoma development - PubMed

Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor and refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers and becomes an attractive therapeutic target. Here we showed that...

www.ncbi.nlm.nih.gov

Interestingly, the Bmi-1-glioblastoma report is from Groningen, The Netherlands and Hubei Key Laboratory of Cell Homeostasis, Wuhan, China.

 

[badger2]

We note that the immortalization of bat lung cells, linking to Tadarida brasiliensis lung cells (Tb1.Lu) for rabies, links the immortalizing agent itself, Bmi-1, to human brain cancer therapy.

 

[badger2]

The ebola mutation, D759G, comparable with Fauci's D614G COVID-19 mutation, happened in Tb1.Lu cells.

 

[badger2]

Obesity would be a factor to consider in mask wearing and increased CO2.

Obesity Hypoventilation Syndrome / COVID-19

Letter to the Editor: Obesity hypoventilation syndrome and severe COVID-19 - PubMed

Letter to the Editor: Obesity hypoventilation syndrome and severe COVID-19

www.ncbi.nlm.nih.gov

'....obesity coexisting with COVID-19 may predispose patients to the risk of more severe conditions.'

 

[badger2]

A question of COVID-19's seasonality in a flu study is in the news, with contradictory reasoning:

COVID-19 may not be seasonal like the flu, study finds: 'Transmission has not slowed down during warm months'

New research suggests that the virus may stick around all year.

www.yahoo.com

'....Gonsenhauser (Ohio State University)...."While there has been speculation that COVID-19 would exhibit seasonality, there has been little supporting evidence of that speculation." '

Gonsenhauser is trained in physiology, genetics and the cognitive science of aging. One could speculate that there is a German genetic background involved here. So, does Gonsenhauser know of the COVID-19 D614G mutation, the one Fauci has commented on, the one that links to Germany?

The question arises as to what role this mutation may play in seasonality, for even a quick search of the literature comes up with the same mutation occurring in influenza:

HA222 Polymorphism / Aspartate-to-Glycine / H1N1

HA222 polymorphism in Influenza A(H1N1) 2009 isolates from Intensive Care Units and ambulatory patients during three influenza seasons - PubMed

Amino acid substitutions which can affect the receptor binding specificity of the influenza virus, like the substitution of aspartic acid with glycine in position 222 of the haemagglutinin (HA) of influenza virus A(H1N1) 2009, have been associated with increased viral pathogenicity and increased...

www.ncbi.nlm.nih.gov

'....substitution of aspartic acid with glycine at position 222....'

 

[badger2]

Interestingly, when we press the d-to-g mutation trajectory, we come upon problematics of access, for the cost to view the HA222 article (above) is $41.95. When we again found the strength and bolstered our courage, we found another d-to-g that links to dengue. Excited at the prospects that this would link to the now-closed snake meat thread, our hopes were dashed, as we discovered (no price [italics]) mentioned to view the entire article:

Jan 2006 Dengue D-to-G Mutation / NS1 / DSS Strain

Impact of dengue virus infection and its control - PubMed

Dengue virus infection has been counted among emerging and re-emerging diseases because of (1) the increasing number of patients, (2) the expansion of epidemic areas, and (3) the appearance of severe clinical manifestation of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), which is...

www.ncbi.nlm.nih.gov

 

[badger2]

Note that when the reader clicks on the above page, one can see "Free Full Text" which access is not available. Likely the first time seeing this type of anomaly, this report from Tailand may have been adjusted for access after the Thais were reporting the use of anti-HIV meds for COVID-19 some months past, though reasons why this might happen are yet unknown.

 

[badger2]

We posted on coronavirus subsistence on surfaces on 12 Feb 2020, in post #391 of the snake meat thread:

Snake Meat......source of chinese virus

We have sent a communication to Italy in regard to the subspecies and type locality of Bungarus multicinctus wanghaotingi. It may not have been investigated. 11 Feb 2020 Coronavirus Likely Jumped from Bats to an 'Intermediate Host' Before Infecting Humans, WHO Says Coronavirus likely jumped...

www.usmessageboard.com

'....mouse hepatitis virus MHV, 20 degrees C, 28 days.'

So this report of today's media links COVID-19 to the same length of time, showing that this ability is embedded in the coronavirus genome:

28-Day COVID-19 Survival on Smartphone Screens

Research finds coronavirus can survive on phone screens for 28 days

The virus that causes COVID-19 can stay active on non-porous surfaces like smartphones for much longer than the flu virus, according to researchers from Australia’s national science agency.

www.yahoo.com

 

[badger2]

Fauci's COVID-19 mutation, D614G arose almost simultaneously in both Germany and China. The trajectory of investigation must include, then, Hutterite genes in North America, that link the D86G mutation in Bowen-Conradi syndrome to both Austria and South Dakota. Stats should eventually show the number of Hutterite cases, if any any details of these cases. We will show that Bowen-Conradi syndrome links to the virulence of COVID-9.

Bowen-Conradi Syndrome
Wikipedia, the free encyclopedia Bowen-Conradi_syndrome
'....EMG1....'

 

[badger2]

Bowen–Conradi syndrome - Wikipedia

en.wikipedia.org

 

[badger2]

A Hutterite collective genome showing those infected with COVID-19 in either the Canadian Prairie Provinces or the U.S. Great Plains, may yield insights that lead back to Europe, or vice versa.

Mutations of a Gene Essential for Ribosome Biogenesis, EMG1, Causes Bowen-Conradi Syndrome

Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome - PubMed

Bowen-Conradi syndrome (BCS) is an autosomal-recessive disorder characterized by severely impaired prenatal and postnatal growth, profound psychomotor retardation, and death in early childhood. Nearly all reported BCS cases have been among Hutterites, with an estimated birth prevalence of 1/355...

www.ncbi.nlm.nih.gov

'....The D86 residue formed a salt bridge with arginine 84 that would be disrupted by the glycine (G) substitution.'

COVID-19 Salt Bridge

Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV - PubMed

The 2019 novel coronavirus (2019-nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes in the 2019-nCoV...

www.ncbi.nlm.nih.gov

'....with continuous hydrogen bonds and salt bridge anchors, indicating their potential in generating immune responses. Some of these epitopes can be potential candidates for development of COVID-19 vaccines.'

While maintaining the epitope idea, it should be mentioned that Bowen-Conradi syndrome is a ribosomopathy. So too is Native American Indian Childhood Cirrhosis (NAIC) whereby the cirhin gene, CIRH1a, is mutated from an arginine (R) to a tryptophan (W). Again, a coronavirus links to this mutation:

1997 Athens, Georgia Avian Infectious Bronchitis Virus R386W

Identification of amino acids involved in a serotype and neutralization specific epitope within the s1 subunit of avian infectious bronchitis virus - PubMed

Localization of neutralizing, serotype specific epitopes of infectious bronchitis virus has been difficult because these epitopes are conformationally dependent. We identified amino acids involved in a serotype specific, conformationally dependent epitope by analysis of the S1 gene of 13...

www.ncbi.nlm.nih.gov

'....the substitutions at residue 386 were from arginine to proline, histidine, or tryptophan....amino acid residues 304 and 386 on the S1 glycoprotein are involved in a virus neutralizing serotype specific epitope.'

 

[badger2]

Mention was made of avian infectious bronchitis virus in the snake meat thread, 27 & 28 Jan, posts #111 & 133, and posts # 385, 564, 582, etc.

 

[badger2]

For the politics and demographics, then, COVID-19 infections of Native Americans carrying the CIRH1a gene mutation would qualify for further investigation for expression of the coronavirus genome that linked Hutterite genes or surface phenomenon of COVID-19.

 

[badger2]

To a list of factors besides COVID-19's increased affinity for ACE2 receptors should be added the mutational machinery mentioned in this Chinese report:

Human SARS-CoV-2 has evolved to reduce CG dinucleotide in its open reading frames - PubMed

The outbreak of COVID-19 has brought great threat to human health. Its causative agent is a severe acute respiratory syndrome-related coronavirus which has been officially named SARS-CoV-2. Here we report the discovery of extremely low CG abundance in its open reading frames. We found that CG...

www.ncbi.nlm.nih.gov

'....We report the discovery of extremely low CG abundance in SARS-CoV-2 open reading frames (ORFs). We found that CG reduction in SARS-Cov-2 is achieved mainly through mutating C/G into A/T and CG is the best target for mutation. Meanwhile, 5'-untranslated region of SARS-CoV-2 has high CG content and is capable of forming an internal ribosome entry site (IRES) to recruit host ribosome for translating its RNA. These features allow SARS-CoV-2 to reproduce efficiently in host cells, because less energy is consumed in disrupting the stem-loops formed by its genomic RNA.

Notably, genomes of cellular orgnisms have very low CG abundance suggesting that mutating C/G into A/T occurs universally in all life forms. Moreover, SRS-CoV-2 has evolved to decrease CG dinucleotide in its open reading frames (ORFs). Moreover, CG is the dinucleotide related to CpG island, mutational hotspot and single nucleotide polymorphism in cellular organisms. After being released into cytoplasm of a host cell, viral RNA is translated immediately to produce viral proteins by using the translational machinery of host cells.
....
The stability of the stem-loop structure is dependent on number of hydrogen bonds formed between bases in the stem part. Because C-G and T-A base-pairs are formed through three and two hydrogen bonds, respectively, a viral RNA strand with high numb of C and G bases will form more stable stem-loops than that with high number of T and A bases....We analysed dinucleotide distribution and stability of twenty-four coronavirus species. We found that ORFs of SARS-CoV-2 have an extremely low abundance of CG dinucleotide. The secondary structure of SARS-CoV-2 genomic RNA is less stable than many other coronaviruses. Therefore, it is suggested that SARS-CoV-2 is more efficient in reproduction than other coronaviruses, because less energy is consumed in disrupting the stem-loops formed by its genomic RNA.

In our opinion, it is the lower C/G content in genomic RNA that allows SARS-CoV-2 to reproduce higher numbes of virus particles before triggering the immunoreaction of host cells, because less energy is consumed in replicating each virus particle.'

 

[badger2]

Geographical and Adult MIS-C

On the snake meat thread, we reported on MIS-C on 8 Jul 2020 and on 10 Aug 2020 (Boston Children's Hospital) on the same thread. It was reported on another thread linking Trump and Fauci on 29 Jul 2020 (7,000 kids in Florida).

16 Oct 2020 MIS-C Now Seen in Adults

A rare Covid-19 complication was reported in children. Now, it's showing up in adults.

"This needs to be in the forefront of every intensive care unit physician's mind," said one expert.

www.nbcnews.com

8 Jul 2020

Snake Meat......source of chinese virus

At Pubmed, there is only one entry for chloroquine use in the suspected COVID-19 intermediate host, Chrysemys: (1985) Chrysemys / Thyroid / Chloroquine https://www.ncbi.nlm.nih.gov/pubmed/3905504 '....chloroquine or bacitracin inhibited the degradation activity.'

www.usmessageboard.com

29 Jul 2020

Trump is upset that Fauci is more popular than him.............

Wow..................just when I thought that Trump couldn't go any lower, he manages to do so. Yesterday, he was bitching at his press conference that Fauci was more popular than him, and he appeared to be a bit butt hurt about it. Sorry, but being president doesn't mean that everyone is...

www.usmessageboard.com

10 Aug 2020

Snake Meat......source of chinese virus

As will be shown, this author has important COVID-19 information. In the authopr's report 1), the name of the drug is not mentioned. The author's report 2) is the important information: 1) 29 Jul 2020 UMBC Chemist Hopes 10-Year-Old-Drug Can Help Those Infected with Coronavirus...

www.usmessageboard.com

 

[midcan5]

More info for the interested reader in link and other sources linked below.

Covid-19 Lessons

The lesson here is the republican party and their followers are a danger both to democracy and to the health and safety of the people. The effort starting largely by Reagan (and before) to destroy government shows today. South Korea is ahead of us in virus testing as is China. Learn this lesson...

www.usmessageboard.com

'Researchers concluded that, if passengers wear surgical masks continuously, very little of the virus spreads, because of how the air is circulated and filtered on the planes.'

https://www.washingtonpost.com/local/trafficandcommuting/defense-department-study-finds-low-risk-of-coronavirus-infection-through-air-on-a-packed-airline-flight/2020/10/15/e84aa092-0e30-11eb-8a35-237ef1eb2ef7_story.html

'The Most Likely Way You’ll Get Infected With Covid-19'

'You don’t have to sanitize your apples anymore, but you do have to wear a mask'

The Most Likely Way You’ll Get Infected With Covid-19

You don’t have to sanitize your apples anymore, but you do have to wear a mask

elemental.medium.com

Long term effects of Covid and vaccine progress:

'Lasting symptoms may not be down to a single syndrome but several different ones'

Long Covid: what we know so far

Lasting symptoms may not be down to a single syndrome but several different ones

www.theguardian.com

'Covid vaccine tracker: when will a coronavirus vaccine be ready?'

Covid vaccine tracker: when will a coronavirus vaccine be ready?

More than 170 teams of researchers are racing to develop a safe and effective vaccine. Here is their progress

www.theguardian.com

"If people think nature is their friend, then they sure don't need an enemy." Kurt Vonnegut

 

[badger2]

Almost every county in Wisconsin is now considered a COVID-19 hotspot.

16 Oct 2020

Almost all of Wisconsin is classified as a COVID 'hot spot'

Officials in the state report some hospitals have already reached 90 percent capacity in their intensive care units.

www.yahoo.com

 

[badger2]

It is unknown how many recent cases testing positive in Wisconsin were sequestered, did or did not wear masks, or spent much time out-of-doors.

 

[badger2]

There is at least one other ribosomopathy to add to the assemblage for Hutterites and Native Americans: 5q-myelodysplastic syndrome, and this syndrome will link to what was posted for bone morphogenetic protein on the snake meat thread for Trump’s osteopath as well as megakaryocytes which we’re shown in both COVID-19 and dengue brain autopsies.

Wall Street Journal, U.S. Reports Highest Daily Coronavirus Cases Since July

U.S. Reports Highest Daily Coronavirus Cases Since July

Daily new coronavirus infections in the U.S. surged to their highest level since late July, approaching numbers seen during the outbreak’s midsummer peak.

www.wsj.com

’....North and South Dakota have the highest ratio of infections, with nine or more new cases per 10,000 people according to Johns Hopkins’s data. Montana and Wisconsin followed with more than six new infections per 10,000 people.’

 

[badger2]

‘Sometimes the best loves leave large tracts of territory unexplored in the Other.’
(Gilles Deleuze)

Unfortunately, the same does not hold for COVID-19 epidemiology. We next link the Bowen-Conradi D-to-G mutation mentioned earlier when comparing Fauci’s COVID-19 D614G, to COVID-19-resistant stromal cells via bone marrow:

Note that dengue links to COVID-19 at this point: brain autopsy

Bowen–Conradi syndrome - Wikipedia

en.wikipedia.org

’....A D86G mutation of EMG1 destroys an EcoRV restriction nuclease site in the most highly conserved region of the protein. Skeletal dysmorphology is seen....The embryos exhibited dramatically decreased cell proliferation, which we also detected in autopsy brain tissue and bone marrow

Sept 2020 Goethe University Hospital, Germany

Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells - PubMed

Previous studies reported on the safety and applicability of mesenchymal stem/stromal cells (MSCs) to ameliorate pulmonary inflammation in acute respiratory distress syndrome (ARDS). Thus, multiple clinical trials assessing the potential of MSCs for COVID-19 treatment are underway. Yet, as...

www.ncbi.nlm.nih.gov

’....We show that MSCs are resistant to SARS-CoV-2 infection and retain their immune modulation potential. To date, the major sources for manufacture of MSC therapeutics are bone marrow (BM) and adipose tissue.’