Wearing it out? Over 200,000 rounds through my S&W Model 29 (most of them max-pressure handloads) and it's doing fine.I've owned a S&W Model 29 with a 6" barrel and a couple Ruger Blackhawks in .44 mag and .41 mag.
Only .44 I have right now is a Uberti Cattleman. It's fun to shoot but I make light loads to keep from wearing it out. The thing is brutal with full factory loads...