Franklin Delanor Roosevelt, hands down. Global influence not seen since the British Empire of the 19th Century, completely changed the face of politics domestic and foreign. With the exception of Jesus, whether real or fictional makes no difference, FDR was more influential than any on the list. Most of the rest were merely tools or criminals or both. Anybody who doubts FDR has any influence in the 21st Century needs to go back to school and finish the 8th grade at least.