colfax_m
Diamond Member
- Nov 18, 2019
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Not according to the paper you cited.#1,552: You are incorrect. COVID-19 can use TPRSS2 as an alternate enzyme. It does not need ACE2.
ACE2 is the binding cite. TMPRSS2 is a protease that introduces a conformational change that results in cellular entry. Whether there are other proteases that could facilitate cellular entry, I don’t know, but ACE2 is always required as the initial binding site.
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