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COVID-19’s Biological Politics

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badger2

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The Nam Dinh nidovirus, however, also occurs in the Yunnan area (Lancang and Nu Rivers) that hosts SARS-CoV-2’s closest relative, RaTG13.

Dec 2017 Pu’er, Yunnan: Nam Dinh Virus, Missing Link in the Nidoviruses

Tongguan (Mojiang copper mine) and Pu’er can be located on this map:

Jinghong Map

Once more returning to Trump’s antimalarial, hydxroxychloroquine, the mosquito vector of Nam Dinh nidovirus is Culex tritaeniorynchus. As will be shown, there is a copper connection to the antiviral effects in SARS-COV-2 infection.

China: Zika Virus Vector, Culex tritaeniorynchus

Linking to another human coronavirus:

Nov 2015 UK: Destruction of CoV-229E on Copper Surfaces

Nov 2020 India: Copper-Mediated SARS-CoV-2 Immunity / Groundwater
 
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Culex tritaeniorynchus is vector of another phelbovirus, Rift Valley Fever, and indeed links to another fruit bat as its reservoir as well as a bat related to RaTG13-harboring Rhinolophus: Hipposideros, also as its reservoir. RVF is considered a biological weapon.

Rift Valley Fever

Being a missing nidovirus link, Nam Dinh virus has all of the necessary genomic criteria to classify it as a nidovirus (except [italics]) the uridylate-specific endoribonuclease mentioned previously for the shrimp nidovirus (gill-associated virus, GAV). A report from Germany links this enzyme to another parasite linking chloroquine-hydroxychloroquine: African sleeping sickness parasite, Trypanosoma brucei:

2008 Germany: Uridylate-Specific / Zinc / African Trypanosomes
‘....TbMP42.’

A report from Saudi Arabia and Malaysia links chloroquine, endoribonuclease, and vitamin D to SARS-CoV-2:

Sep 2020 Vitamin D / SARS-CoV-2 Nsp15
 
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This report from Israel shows monoclonal antibodies are working against SARS-CoV-2:

21 Aug 2021 Tel Aviv: MD65 & BL6 Monoclonal Antibodies
’....Thus, despite the accumulation of spike mutations, the highly potent MD65 and BL6 monoclonal antibodies retain their ability to bind the prevalent viral mutants, effectively protecting against B.1.1.7 and B.1.351 variants.’
 
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The following report includes a Conflicts of Interest section:

17 Aug 2021 SARS-CoV-2 Monoclonal Antibodies
’....Thus, 2C08-like antibodies can be induced by SARS-CoV-2 vaccines and mitigate resistance by circulating variants of concern.’
 
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Monoclonal antibodies against SARS-CoV-2 links to poliovirus:

25 Aug 2021 SARS-CoV-2 / Fc-gamma Receptor
’Antibody-mediated protection depends on the Fc domain and Fc-gamma receptor-expressing immune cells.’

Aug 1999. Tokyo: Poliovirus Fc-gamma / Monoclonal Antibodies
 
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Links to the new Japanese Delta variant N501S mutation:

Atlantic Salmon Bafinivirus: S501

Chinook Salmon Bafinivirus: S501

Ball Python Nidovirus 1: S501
 
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Ivermectin is going to be linked to Gracie’s fenofibrate thread, so recalling its history, the origin of ivermectin is from a golf course near Ito City, which may be compared with Neophocaenus at Shimuzu Hrbor, west of Ito.

Shimuzu Harbor / Ito City
 
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Shi’s Wuhan lab report for WSSV of crayfish (2006):

It will be shown that ivermectin, from Streptomyces avermitilis at Ito City, Japan, links to algae that harbor Streptomyces, and this same alga, Ulva, can differentiate between the antiviral effects for both yellow head virus (YHV) and white spot syndrome (WSSV) infecting shrimp.

(1986) H.G. Davies, R.H. Green, Avermectins and Milbemycins
’....The source was another example of the fecund Japanese soil, this time from Kawana, Ito City.’

May 2021 Thailand: YHV / WSSV / Ulva intestinalis
’....Ulva intestinalis hot water crude extract (Ui-HWCE) exhibits growth promoting, immune stimulatory and antiviral activity.’

The Ui-HCWE was antiviral only for the nidovirus, YHV, not for Wuhan lab’s WSSV.

Feb 2019 Desertomycin from Streptomyces-Ulva / MCF-7 Breast Cancer

Ivermectin indeed docks to the SARS-CoV-2 virus:

Icahn Medical School, Mt. Sinai, New York: Ivermectin Docks to the SARS-CoV-2 Spike Receptor Binding Domain Attached to ACE2
 
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Ivermectin (from Omura’s Kawana golf course Streptomyces) can now be linked with azithromycin (used in combination with paromomycin [Streptomyces]) via Satoshi Omura’s cerulenin, which links to fatty acid biosynthesis and Gracie’s fenofibrate thread which includes the statins:

Satoshi Omura / Cerulenin
‘....Cerulenin, produced by a true fungus, Acremonium caerulens, proved to be the first inhibitor of fatty acid (lipid) biosynthesis ever found. It became the lead compound for development of the medically important statins, inhibitors of cholesterol biosynthesis, and it remains a pivotal research reagent to this day.’

Azithromycin is used in combination with paromomycin (from Streptomyces rimosus), a secondary metabolite of this organism, which also produces oxytetracycline and tetracycline. Azithromycin and paromomycin are in combination against cryptosporidiosis. According to the Wiki paromomycin page

‘Polyketide Synthesis: S. Rimosus’s oxytetracycline polyketide synthase acyl carrier protein differs from most ACPs by having a C-terminus extension. Reference :
White SW, et al, “The Structural Biology of Type II Fatty Acid Biosynthesis” .‘

White SW links Omura’s cerulenin:

Mar 2001 White SW et al / Cerulenin

Azithromycin binds to the SARS-CoV-2 RBD at position Y103. This links, without mutating, to TGEV spike protein position 103, which is a tyrosine (Y). TGEV is the porcine coronavirus that has been shown in a German study to be able to subsist on metal surfaces for up to 28 days.
 
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If a porcine virus (PRRSV) is the most ancient ancestor to SARS-CoV-2, viability on surfaces may correlate with other time windows in its biology.

From Promedmail....
Lancet Infectious Diseases: Post-Vaccination Infection Risk Factors
’ To conclude, the odds of post-vaccination infection following the first dose was increased in frail, older adults and in those living in deprived areas, and were decreased in individuals without obesity. Compared with unvaccinated controls, after the second vaccine dose, individuals were less likely to have prolonged illness (symptoms for 28 days or more), more than 5 symptoms in the first week of illness, or present to hospital.’
 
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Some environmental comparisons of viral persistence are:

’SARS-CoV-1 on plastic 22-25 deg. C: 28 days (Chan, et al, 2011)’

TGEV >49 days water @ 4 deg. C
TGEV reagent water 49 days @ 25 deg. C
HCov E229 > 130 days @ 4 deg. C
FIPV > 130 days @ 4 deg. C

’SARS-CoV-2 viral RNA persisted in feces for 33 days after the patient was tested negative for viral RNA in the respiratory tract....The indicator organism (poliovirius-1) showed six times longer persistence in water than HCoV of FIPV.’
 
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We’ll review the history of ivermectin, linking it to an Oregon pocket gopher. Along the way, this German study will be considered:

Jun 2021 Ivermectin gegen Hakenwurm — und Coronavirus?
 

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Conclusion being that there are lots of under utilized alternative medications to ameliorate covid symptoms.
 
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Conclusion being that there are lots of under utilized alternative medications to ameliorate covid symptoms.
Other people may be more interested in alternate chemistry that physically attaches to the communist SARS-CoV-2 virus such as ivermectin.

 
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It looks like fruit-bat vectors, since Nipah (with a high mortality rate) samples also came from bitten fruits:

6 Sep 2021 Kozhikode Village, India / Nipah Virus Outbreak
’....rambutan fruits....’
 

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