COVID-19’s Biological Politics

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Rambutan has anti-SARS-CoV-2 activity:

Aug 2021 Korea: Rambutan / SARS-CoV-2

Geraniin Inhibits the Entry of SARS-CoV-2 by Blocking the Interaction between Spike Protein RBD and Human ACE2 Receptor - PubMed

The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite the development of vaccines, the emergence of SARS-CoV-2 variants and the absence of effective therapeutics demand the continual investigation of COVID-19. Natural...

pubmed.ncbi.nlm.nih.gov

 

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As the report in post #721 states, ‘Geraniin formed eight hydrogen bonds (Arg 403, Tyr449, Tyr453, Gln493, Ser4945, Gln498, Gly502, Tyr505), four van der Waals interactions (Tyr 495, Gly496, Thr500, Asn501) and one pi-pi (Tyr505) with the spike protein.’

 

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Reviewing the literature on funding of coronavirus research, links Fau Chi’s NIH, Daszak, the Gates Foundation, et al:

Daszak Deleted Tweet

EcoHealth’s Peter Daszak Deletes Tweet Revealing Wuhan Lab Researchers At Fauci-Funded Conference. – Real News Aggregator

realnewsaggregator.com

‘....”you can train in BSL-4 lab in Wuhan”...Bill and Melinda Gates Foundation....Duke-NUS Medical School, Singapore....Coalition for Epidemic Preparedness Innovations....NIH Allergy and Infectious Diseases....10 Dec 2019....’

 

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Obama and Biden funding of Duke-NUS Singapore compares to Daszak attending the Nipah Conference two weeks before China reported its first case (shrimp seller “Patient Zero”) of SARS-CoV-2.

Dec 2019 Nipah International Conference, Singapore

Nipah Virus International Conference

Your nipah 20

nipah2019.miceapps.com

Understanding the Risk of Bat Coronavirus Emergence
(click on Award Abstract)

Award Information | HHS TAGGS

HHS’ Tracking Accountability in Government Grants System (TAGGS) website is a robust reporting tool that displays detailed information on government grants.

taggs.hhs.gov

 

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Nipah virus bat vector eats rambutan fruits, which contain an interesting anti-SARS-CoV-2 compound, geraniin. Here are the locations on the spike of this virus that geranii herba attaches, in the receptor binding domain (RBD), receptor binding motif (RBM), and ACE2:

Geranii Herba as a Potential Inhibitor of SARS-CoV-2 Main 3CLpro, Spike RBD, and Regulation of Unfolded Protein Response: An In Silico Approach - PubMed

Hence, the compounds present in Geranii Herba could be used as possible drug candidates for the prevention/treatment of SARS-CoV-2 infection.

pubmed.ncbi.nlm.nih.gov

 

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Ivermectin physically attaches to SARS-CoV-2 in vitro, and it cannot be disproven not to also do so in vivo. The geraniin of post #725 also attaches to SARS-CoV-2 spike. Therefore, we are interested in criteria used in this ivermectin trial to determine eligibility, because attachment sites for these mentioned also compare to attachment sites for De Santis-Regeneron monoclonal antibodies. References in this article are valuable:

Tel Aviv Trial for Ivermectin

Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19 – A double-blind, randomized placebo-controlled trial

Background Ivermectin, an anti-parasitic agent, also has anti-viral properties. Our aim was to assess whether ivermectin can shorten the viral shedding in patients at an early-stage of COVID-19 infection. Methods The double-blinded trial compared patients receiving ivermectin 0·2 mg/kg for 3...

www.medrxiv.org

’ivermectin favorable outcome....median age 35 years....’

 

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The Tel Aviv study continues: ‘Viral load of ivermectin group decreased faster than placebo at early stage of intervention, during days two to six. As spontaneous recovery takes place also in the placebo group, viral load is decreased, having similar viral load since day eight....Kaplan-Meier analysis adjusted to symptom onset showed the significant difference between ivermectin group and placebo arms during the course of treatment.
....
To further explore antiviral activity, we observed the culture viability in both placebo and ivermectin groups. The results showed the advantage of ivermectin, where only 13% of samples stayed positive on days two to six, while 48% stayed positive in placebo group. The broad-spectrum antiviral activity of ivermectin is related to its ability to target host importin (IMP) alpha/beta1 nuclear transport proteins, responsible for nuclear entry of cargoes of viral proteins, which in turn blocks host antiviral activity.

Major criticism is that does is 35 times higher than maximum plasma copncentration. But higher doses may not be necessary as some models predict that the lungs achieve higher concentrations, up to 10-fold highere than in serum. In addition, ivermectin concentrations in blood may not reflect activity of its other metabolites, which might be active agents.

A double-blind, randomized trial conducted in Columbia included 476 mild patients....as the authors mentioned in their limitations, decreased viral load or viral shedding better reflects the antiviral activity of the drug rather than longevity of symptoms. Peer-reviewed randomized control trials from Bangladesh support our findings of faster viral clearance in the ivermectin group, and in a small RCT from Spain, treatment with ivermectin showed a tendency toward faster viral clearance....leads to almost 90% non-infectious status as day four (one day after ending treatment, among ivermectin users. From the public health point of view, it may shorten isolation time, which can serve as a major relief of economic and social burden.’

 

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First animals in Mongolia infected with C-19 are beavers:

Beavers in Mongolia test Covid positive

Beavers in Mongolia test Covid positive

www.tribuneindia.com

 

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In China, C-19’s current resurgence (139 cases in four days) seems to be happening via a traveler. Quarantine of immigrants is not assured.

China’s First School-Centered COVID-19 Resurgence: Longer Incubation Feared

E. China's Putian deals with nation's 1st school-centered COVID-19 resurgence; longer incubation feared - Global Times

www.globaltimes.cn

’....involving unvaccinated students.’

Putian City, Fujian

https://new.qq.com/omn/20210911/20210911A04AYC00.html

’....he entered Xiamen Airlines from Singapore....’

 

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In China, C-19’s current resurgence (139 cases in four days) seems to be happening via a traveler. Quarantine of immigrants is not assured.

China’s First School-Centered COVID-19 Resurgence: Longer Incubation Feared

E. China's Putian deals with nation's 1st school-centered COVID-19 resurgence; longer incubation feared - Global Times

www.globaltimes.cn

’....involving unvaccinated students.’

Putian City, Fujian

https://new.qq.com/omn/20210911/20210911A04AYC00.html

’....he entered Xiamen Airlines from Singapore....’

The reader can see depicted the airship and timeline for the traveler in the Fujian report. After the number 852 it reads ‘Singapore.’

 

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Kindergartens are hit by the virus, and sometimes it’s asymptomatic.

139 Positive Cases in Four Days

四天139例阳性感染者 福建本土疫情三个问题凸显-中新网

(记者 龙敏)“坚决遏制疫情蔓延”，面对9月10日以来发生的本土疫情，福建官方如是喊话。而在此次福建本土疫情的始发地，莆田市仙游县已形成铺头学校、协胜鞋厂两条传播链。

www.chinanews.com

’....8 children in kindergarten....’

Testing has now been ramped up.

Number of Toll Stations Increased to 90

ç¦å»ºç´¯è®¡ç¡®è¯152ä¾ï¼ç®¡æ§æªæ½å级ï¼å¦æ ¡å课ãæ¯ç¹å³éâ¦â¦

福建累计确诊152例！管控措施升级：学校停课、景点关闭……,福建,泉州,漳州,莆田市,核酸

www.163.com

’....Sampling will be carried out from 8 to 20 o’clock every day....’

 

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This is an excellent example of Chinese communist propaganda. The video may take time to load, stall, then load again. The Ugandan in the video. We wondered specifically how Uganda was paid off to cultivate this classic commie propaganda, complete with (vaccination symbolism [italics]):

15 Sep 2021 Experts Hail China’s People-Centered Philosophy of Dealing With COVID-19
www.news.cn/english/2021-09/15/c_1310189426.htm

13 Sep 2021 Museveni’s China Visit: Hunan Investors to Inject Shs6.3trn Into Industrial Park Development in Uganda

Museveni’s China Visit: Hunan Investors to Inject Shs6.3trn into Industrial Park Development in Uganda | The Kampala Post

A group of investors from Hunan, China's 7th most populous province and the 10th most extensive province by area -- want to invest about $1.8billion (about Shs6.3 trillion) in developing an industrial park in Katosi, Mukono district.

www.kampalapost.com

’....is one of the five Memoranda of Understanding under the framework cooperation agreement between Uganda and Hunan Province....signed in June 2019.’

 

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This Fujian outbreak is targeting younger ages:

16 Sep 2021 Fujian Outbreak: 40% of Cases Under 12 Years Old

福建莆田本土确诊病例中四成以上为12岁以下

莆田确诊病例四成以上为12岁以下

www.163.com

’....Not encountered before, 58 are 14 and below....patients are not allowed to be accompanied.’

 

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Dumbing Down: Chinese Communists at the Kazakhstan Border

Further on in this post links Wuhan Institute of Virology to the Kazahstan border.

Communist contempt and disregard is noted. From the beginning, what remained esoteric was information about all of the (rest of SARS-CoV-2 [italics]) that remained outside the Homo sapiens host. The current report from Nature fixates on Wuhan, while completely disregarding the Chinese communist expressways that link Mojiang, (source of SARS-CoV-2’s closest relative), Not far from the nasty Kunming Flower and Animal Market, etc., to Wuhan. In addition, no bats were being sold at Huanan Seafood Market, and the report is anal rentitive: it can’t seem to cough up two nucleotide differences to feed to the reader-prisoner, a la Scotland Yard, paranoid that indeed there will be lab manipulations if the information goes public.

16 Sep 2021 Nature.com. ‘Did the Coronavirus Jump From Animals Twice?’

Did the coronavirus jump from animals to people twice?

A preliminary analysis of viral genomes suggests the COVID-19 pandemic might have multiple animal origins — but the findings still have to be peer reviewed.

www.nature.com

’....originated in multiple markets in Wuhan....two broad lineages, known as A and B, which have key genetic differences....Huanan Seafood Market in Wuhan, which also sold wild animals....the findings are “consistent with there being at least two introductions of SARS-CoV-2 into the human population,” says David Robertson, a virologist at the University of Glasgow, UK. Lineages A and B are defined by two key nucleotide differences. But some of the earliest genomes have a combination of these differences.
....
A study published in June found that live animals susceptible to SARS-CoV-2 such as raccoon dogs and mink, were sold in numerous markets in Wuhan....It’s more likely that the pandemic had its origins in the wildlife trade.’

Wuhan Institute of Virology cites this mosquito-pig report:

Vector Competence / Tritaeniorynchus / Pigs

Vector competence of certain Culex and Aedes mosquitoes for the Chittoor virus, the Indian variant of the Batai virus - PubMed

Chittoor virus (CHITV), a mosquito-borne bunyavirus (Orthobunyavirus: Bunyaviridae) isolated in India, has been found to be antigenically close to the Batai virus (BATV), which has a wide distribution across Asia, Europe, and Africa. The latter virus causes influenza-like illness in humans and...

pubmed.ncbi.nlm.nih.gov

The only study that cites the vector competence report, above, is this one:

Feb 2021 Wuhan Institute of Virology

Pathogenesis and Immune Response of Ebinur Lake Virus: A Newly Identified Orthobunyavirus That Exhibited Strong Virulence in Mice - PubMed

<span><i>Orthobunyaviruses</i> are a group of viruses with significant public and veterinary health importance. These viruses are mainly transmitted through mosquito-, midge-, and tick-vectors, and are endemic to various regions of the world. Ebinur Lake virus (EBIV), a newly identified member...

pubmed.ncbi.nlm.nih.gov

 

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Above should read ‘anal retentive.’

 

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If minks were being sold in Wuhan, they were certainly sold at Kunming. Mink coronavirus spike at position 1188 is a G (glycine). It is also a G for the yak coronavirus spike at that position, linking Chinese females riding of yaks north of Mojiang copper mine to mink-fur clothing. RaTG13, SARS-CoV-2’s closest relative at Mojiang has G at spike position 75. It is also a glycine for mink. Was the glycine itself the cause of Fau Chi’s freudian slip during his youtube video and not the entire SARS-CoV-2 mutation, D614G?

 

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Reinforcing yak as intermediate host of SARS-CoV-2 is this report from Belarus:

Sep 2020 Belarus / Yak / SARS-CoV-2

SARS-CoV-2: Structural diversity, phylogeny, and potential animal host identification of spike glycoprotein - PubMed

To investigate the evolutionary history of the current pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a total of 137 genomes of coronavirus strains with release dates between January 2019 and 25 March 2020, were analyzed. To investigate the potential...

pubmed.ncbi.nlm.nih.gov

’....Therefore, our results suggest that human SARS-CoV-2, responsible for the current outbreak of COVID-19, could also come from yak as an intermediate host.’

 

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The irony in this communist-based report is that the virus is lurking in nature on the Yunnan side of the Myanmar border. Riuli is well known for drug trafficking and prostitution.

17 Sep 2021 Chinese Border Town on Lockdown After Burmese Migrants Test Positive for COVID-19

Chinese Border Town on Lockdown After Burmese Migrants Test Positive for COVID-19

NANG SENG NOM — Chinese authorities have locked down the city of Ruili in Yunnan Province after two Burmese migrants tested positive for COVID-19 over the weekend. The two Burmese migrant workers entered Ruili—referred to as Shweli in Burmese—on September 12. “Nobody is allowed to go out of...

bnionline.net

 

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Those most vulnerable to COVID-19 show a neuro link to mosquito-vectored viruses mentioned above and Japanese encephalitis:

18 Sep 2021 SMI2 Russia: Uchenye nazvali kategorii naibolee iuazimykh k COVID-19 liudei
Scientists Have Named the Categories of People Most Vulnerable to COVID-19
’....Sovmestno issledovanie uchenykh Edinburskogo, Nottingemskogo i Oksfordskogo universiteta pokazalo, chto u liudei s sindromom Dauna risk smerti of COVID-19 byl primerno v 13 raz vyshe, chem u naseleniia v tselom, dazhe posle vaktsinatsii, v to vremia kak u liudei s dementsiei i bolezn’iu Parkinsona risk smerti ot koronavirusa uvelichivalsia vdvoe.
A joint study by researchers at the Universities of Edinburgh, Nottingham, and Oxford, showed that people with Down syndrome were about 13 times more likely to die from COVID-19 than the general population, even after vaccination, while people with dementia and the disease, Parkinson’s risk dying from coronavirus is doubled.

Bylo ustanovleno, chto otchasti uvelichenie riska bylo sviazano s kontaktami etikh patsientov s litsami, osushchestvliaiushchimi ukhod.
Issledovanie takzhe pokazalo, chto bolee vysokomu risku infitsirovaniia podverzheny pozhilye liudi i muzhchiny, a takzhe vykhodtsy iz Indii i Pakistana.
Part of the increased risk was found to be due to the contact of these patients with caregivers. The study also showed that older people and men as well as people from India and Pakistan, are at higher risk of infection.’

 

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Earlier, the WHO (28 Jun 2021) reported on the Bashkortostan facility for Sputnik V vaccine:

15 Sep 2021 Moscow Times: WHO Suspends Sputnik V Approvval Process Over Manufacturing Breaches

WHO Suspends Sputnik V Approval Process Over Manufacturing Breaches - The Moscow Times

The World Health Organization (WHO) has suspended its approval process for Russia’s Sputnik V coronavirus vaccine, pending a fresh inspection of at least one Russian factory manufacturing the shot.

www.themoscowtimes.com