Cancer Vaccine That Essentially Cures Cancer: US Tiptoeing In At A Snail's Pace

[Silhouette]

The Hunt for Effective Anticancer Vaccines

The American study involved only 6 participants with previously untreated melanoma, but, the authors wrote, “4 had no recurrence at 25 months after vaccination, while two with recurrent disease were subsequently treated with anti-PD-1 (anti-programmed cell death-1) therapy and experienced complete tumour regression, with expansion of the repertoire of neoantigen-specific T cells.”1

6 whole participants while other countries are diving in? You're all heart BigPharma USA!

The German team also used exome sequencing to develop personalized vaccines for 13 patients with melanoma. But they used RNA molecules to deliver the vaccine and trigger the participants' immune systems. Nine of the participants, 8 given just the vaccine and 1 given the vaccine plus a checkpoint inhibitor, remained cancer-free 12 to 23 months later.

They realized, however, that “the vast majority of mutations are unique to the individual patient. Hence, mutanome vaccines need to be individually tailored and rapidly manufactured on-demand.”

The team theorized that, because of the similarities between embryonic cells and tumor cells, the body might be coaxed into an immunogenic anticancer response by introducing induced pluripotent stem (iPS) cells.


They used blood samples from the mice to create genetically matching iPS cells, irradiated the iPS cells to prevent proliferation and teratomas, and injected them into a group of mice once a week for 4 weeks. One group of mice received the iPS cells alone. Another received the cells plus the adjuvant CpG, a known immune-stimulating agent. A third group received CpG alone. Then they transplanted a mouse breast cancer line into the test animals. A fourth received a control solution.

....while they grew robustly in the various control groups, they shrank in 7 of the 10 mice given the combination of iPS cells and CpG. Two completely rejected the tumor cells and lived cancer-free for more than a year after transplantation.

******

So the way I understand it is, they use the patient's particular cancer's dna to train up the T-cells to recognize and destroy the cancer. Recognition and destruction are the key because it disguises itself so the body just thinks everything is OK as the cancer grows unchecked.

Before this gets slammed into health forum, let the masses who visit "Current Events" have a shot at reading it and discussing it? Sort of like the moderators' contribution to saving lives as the word spreads?

I lost several family members and friends to cancer. They would've liked to have known about this awhile back. However, vaccines and how they work have been known about for some time. With viruses, they used a modified live virus often, one that isn't deadly but is so close that it trains the immune system to attack the real deal. Also they use killed virus with similar effects of recognition. Seems someone's thinking cap could've been on a long time ago about this one.

True they have to sample tumors from each individual patient because of the wide variation in mutated dna intrinsic to each type of cancer and patient in which it sits. But I think they could streamline the process and get 'er done. It might cut into chemo $$ though. Might be the reason the US is dragging ass.

Discuss.

 

[JakeStarkey]

Need more trials with lots more people.

Hope it is as promising as it looks.

 

[fncceo]

Moving to conspiracy?

 

[bgrouse]

Moving to conspiracy?

It's a conspiracy that big pharma is into making money vs saving people? Or that cancer is more profitable to treat than to cure?

 

[Silhouette]

Moving to conspiracy?

Why? Do you have stock in BigPharma?

 

[william the wie]

90+% of cancers and CV events can be prevented by the same EDTA di-Calcium found in your mayonnaise jar. Similar numbers are found with other food preservative, as in the preservatives in breakfast cereals give the US one of the lowest stomach cancer rates in the world. The FDA prevents such health claims by manufacturers but just google food preservatives and cancer prevention then you can make your own decisions on the matter. Then google for suppliers. If you ignore the FDA and its revolving door you can get the same results much cheaper than this unneeded breakthrough.

 

[fncceo]

he FDA prevents such health claims by manufacturers

... because they're weapons-grade bollocks.

 

[Weatherman2020]

The Hunt for Effective Anticancer Vaccines

The American study involved only 6 participants with previously untreated melanoma, but, the authors wrote, “4 had no recurrence at 25 months after vaccination, while two with recurrent disease were subsequently treated with anti-PD-1 (anti-programmed cell death-1) therapy and experienced complete tumour regression, with expansion of the repertoire of neoantigen-specific T cells.”1

6 whole participants while other countries are diving in? You're all heart BigPharma USA!

The German team also used exome sequencing to develop personalized vaccines for 13 patients with melanoma. But they used RNA molecules to deliver the vaccine and trigger the participants' immune systems. Nine of the participants, 8 given just the vaccine and 1 given the vaccine plus a checkpoint inhibitor, remained cancer-free 12 to 23 months later.

They realized, however, that “the vast majority of mutations are unique to the individual patient. Hence, mutanome vaccines need to be individually tailored and rapidly manufactured on-demand.”

The team theorized that, because of the similarities between embryonic cells and tumor cells, the body might be coaxed into an immunogenic anticancer response by introducing induced pluripotent stem (iPS) cells.


They used blood samples from the mice to create genetically matching iPS cells, irradiated the iPS cells to prevent proliferation and teratomas, and injected them into a group of mice once a week for 4 weeks. One group of mice received the iPS cells alone. Another received the cells plus the adjuvant CpG, a known immune-stimulating agent. A third group received CpG alone. Then they transplanted a mouse breast cancer line into the test animals. A fourth received a control solution.

....while they grew robustly in the various control groups, they shrank in 7 of the 10 mice given the combination of iPS cells and CpG. Two completely rejected the tumor cells and lived cancer-free for more than a year after transplantation.

******

So the way I understand it is, they use the patient's particular cancer's dna to train up the T-cells to recognize and destroy the cancer. Recognition and destruction are the key because it disguises itself so the body just thinks everything is OK as the cancer grows unchecked.

Before this gets slammed into health forum, let the masses who visit "Current Events" have a shot at reading it and discussing it? Sort of like the moderators' contribution to saving lives as the word spreads?

I lost several family members and friends to cancer. They would've liked to have known about this awhile back. However, vaccines and how they work have been known about for some time. With viruses, they used a modified live virus often, one that isn't deadly but is so close that it trains the immune system to attack the real deal. Also they use killed virus with similar effects of recognition. Seems someone's thinking cap could've been on a long time ago about this one.

True they have to sample tumors from each individual patient because of the wide variation in mutated dna intrinsic to each type of cancer and patient in which it sits. But I think they could streamline the process and get 'er done. It might cut into chemo $$ though. Might be the reason the US is dragging ass.

Discuss.

What we need is more bigger government!

Hilarious how you leftards go around saying the government shoots innocents and prevent life saving drugs from getting to people while screaming we need a bigger more powerful government.

 

[MindWars]

The Hunt for Effective Anticancer Vaccines

The American study involved only 6 participants with previously untreated melanoma, but, the authors wrote, “4 had no recurrence at 25 months after vaccination, while two with recurrent disease were subsequently treated with anti-PD-1 (anti-programmed cell death-1) therapy and experienced complete tumour regression, with expansion of the repertoire of neoantigen-specific T cells.”1

6 whole participants while other countries are diving in? You're all heart BigPharma USA!

The German team also used exome sequencing to develop personalized vaccines for 13 patients with melanoma. But they used RNA molecules to deliver the vaccine and trigger the participants' immune systems. Nine of the participants, 8 given just the vaccine and 1 given the vaccine plus a checkpoint inhibitor, remained cancer-free 12 to 23 months later.

They realized, however, that “the vast majority of mutations are unique to the individual patient. Hence, mutanome vaccines need to be individually tailored and rapidly manufactured on-demand.”

The team theorized that, because of the similarities between embryonic cells and tumor cells, the body might be coaxed into an immunogenic anticancer response by introducing induced pluripotent stem (iPS) cells.


They used blood samples from the mice to create genetically matching iPS cells, irradiated the iPS cells to prevent proliferation and teratomas, and injected them into a group of mice once a week for 4 weeks. One group of mice received the iPS cells alone. Another received the cells plus the adjuvant CpG, a known immune-stimulating agent. A third group received CpG alone. Then they transplanted a mouse breast cancer line into the test animals. A fourth received a control solution.

....while they grew robustly in the various control groups, they shrank in 7 of the 10 mice given the combination of iPS cells and CpG. Two completely rejected the tumor cells and lived cancer-free for more than a year after transplantation.

******

So the way I understand it is, they use the patient's particular cancer's dna to train up the T-cells to recognize and destroy the cancer. Recognition and destruction are the key because it disguises itself so the body just thinks everything is OK as the cancer grows unchecked.

Before this gets slammed into health forum, let the masses who visit "Current Events" have a shot at reading it and discussing it? Sort of like the moderators' contribution to saving lives as the word spreads?

I lost several family members and friends to cancer. They would've liked to have known about this awhile back. However, vaccines and how they work have been known about for some time. With viruses, they used a modified live virus often, one that isn't deadly but is so close that it trains the immune system to attack the real deal. Also they use killed virus with similar effects of recognition. Seems someone's thinking cap could've been on a long time ago about this one.

True they have to sample tumors from each individual patient because of the wide variation in mutated dna intrinsic to each type of cancer and patient in which it sits. But I think they could streamline the process and get 'er done. It might cut into chemo $$ though. Might be the reason the US is dragging ass.

Discuss.

There has to be something more to it. I don't see big Pharma wanting to cure it since it is a multi billion dollar making business . To have a vaccine for it Hmmm they've got something up their sleeves. I sure in the hell wouldn't trust this bs.

These same bastards gave people potion via a vaccines a few decades ago, they've had HIV virus in some other batch of vaccines....

Big Pharma is to dam crooked.

 

[MindWars]

I don't why people gotta be so quick to say " conspiracy" it is not a fkn conspiracy they have come up with a vaccine the " THINK" might work on cancer.

 

[Borillar]

Maybe with passage of the "Right to try" law, more patients will be allowed to try these new treatments.

 

[JustAnotherNut]

There have been a lot of cancer cures and research and treatments, etc for many years that have all been blackwalled in favor of profit at the risk & cost of lives. I doubt this will go anywhere either or at best will take years before it's available

 

[theDoctorisIn]

I've read some articles on this. It's promising, but far from a miracle cure.

The biggest issue is that there are hundreds of different types of cancer, all of which attack the body in different ways. All of these tests have focused on melanoma - a terrible disease - but only one of hundreds.

The whole "big pharma" conspiracy stuff is nonsense - there are a lot of pharmaceutical companies that don't make chemo drugs - any of them would love to own the cure for cancer.

 

[JustAnotherNut]

I've read some articles on this. It's promising, but far from a miracle cure.

The biggest issue is that there are hundreds of different types of cancer, all of which attack the body in different ways. All of these tests have focused on melanoma - a terrible disease - but only one of hundreds.

The whole "big pharma" conspiracy stuff is nonsense - there are a lot of pharmaceutical companies that don't make chemo drugs - any of them would love to own the cure for cancer.

Like Mylan? They don't need chemo or a cancer cure, they have Epi-pens. Too bad FDA doesn't allow the drops as an alternative

 

[jon_berzerk]

The Hunt for Effective Anticancer Vaccines

The American study involved only 6 participants with previously untreated melanoma, but, the authors wrote, “4 had no recurrence at 25 months after vaccination, while two with recurrent disease were subsequently treated with anti-PD-1 (anti-programmed cell death-1) therapy and experienced complete tumour regression, with expansion of the repertoire of neoantigen-specific T cells.”1

6 whole participants while other countries are diving in? You're all heart BigPharma USA!

The German team also used exome sequencing to develop personalized vaccines for 13 patients with melanoma. But they used RNA molecules to deliver the vaccine and trigger the participants' immune systems. Nine of the participants, 8 given just the vaccine and 1 given the vaccine plus a checkpoint inhibitor, remained cancer-free 12 to 23 months later.

They realized, however, that “the vast majority of mutations are unique to the individual patient. Hence, mutanome vaccines need to be individually tailored and rapidly manufactured on-demand.”

The team theorized that, because of the similarities between embryonic cells and tumor cells, the body might be coaxed into an immunogenic anticancer response by introducing induced pluripotent stem (iPS) cells.


They used blood samples from the mice to create genetically matching iPS cells, irradiated the iPS cells to prevent proliferation and teratomas, and injected them into a group of mice once a week for 4 weeks. One group of mice received the iPS cells alone. Another received the cells plus the adjuvant CpG, a known immune-stimulating agent. A third group received CpG alone. Then they transplanted a mouse breast cancer line into the test animals. A fourth received a control solution.

....while they grew robustly in the various control groups, they shrank in 7 of the 10 mice given the combination of iPS cells and CpG. Two completely rejected the tumor cells and lived cancer-free for more than a year after transplantation.

******

So the way I understand it is, they use the patient's particular cancer's dna to train up the T-cells to recognize and destroy the cancer. Recognition and destruction are the key because it disguises itself so the body just thinks everything is OK as the cancer grows unchecked.

Before this gets slammed into health forum, let the masses who visit "Current Events" have a shot at reading it and discussing it? Sort of like the moderators' contribution to saving lives as the word spreads?

I lost several family members and friends to cancer. They would've liked to have known about this awhile back. However, vaccines and how they work have been known about for some time. With viruses, they used a modified live virus often, one that isn't deadly but is so close that it trains the immune system to attack the real deal. Also they use killed virus with similar effects of recognition. Seems someone's thinking cap could've been on a long time ago about this one.

True they have to sample tumors from each individual patient because of the wide variation in mutated dna intrinsic to each type of cancer and patient in which it sits. But I think they could streamline the process and get 'er done. It might cut into chemo $$ though. Might be the reason the US is dragging ass.

Discuss.

you act as if there is only one type of cancer

in order to be successful there will have to be many cures found

chemo is cheap

compared to my biologic

which runs 32 grand every 21 days

 

[theDoctorisIn]

The Hunt for Effective Anticancer Vaccines

The American study involved only 6 participants with previously untreated melanoma, but, the authors wrote, “4 had no recurrence at 25 months after vaccination, while two with recurrent disease were subsequently treated with anti-PD-1 (anti-programmed cell death-1) therapy and experienced complete tumour regression, with expansion of the repertoire of neoantigen-specific T cells.”1

6 whole participants while other countries are diving in? You're all heart BigPharma USA!

The German team also used exome sequencing to develop personalized vaccines for 13 patients with melanoma. But they used RNA molecules to deliver the vaccine and trigger the participants' immune systems. Nine of the participants, 8 given just the vaccine and 1 given the vaccine plus a checkpoint inhibitor, remained cancer-free 12 to 23 months later.

They realized, however, that “the vast majority of mutations are unique to the individual patient. Hence, mutanome vaccines need to be individually tailored and rapidly manufactured on-demand.”

The team theorized that, because of the similarities between embryonic cells and tumor cells, the body might be coaxed into an immunogenic anticancer response by introducing induced pluripotent stem (iPS) cells.


They used blood samples from the mice to create genetically matching iPS cells, irradiated the iPS cells to prevent proliferation and teratomas, and injected them into a group of mice once a week for 4 weeks. One group of mice received the iPS cells alone. Another received the cells plus the adjuvant CpG, a known immune-stimulating agent. A third group received CpG alone. Then they transplanted a mouse breast cancer line into the test animals. A fourth received a control solution.

....while they grew robustly in the various control groups, they shrank in 7 of the 10 mice given the combination of iPS cells and CpG. Two completely rejected the tumor cells and lived cancer-free for more than a year after transplantation.

******

So the way I understand it is, they use the patient's particular cancer's dna to train up the T-cells to recognize and destroy the cancer. Recognition and destruction are the key because it disguises itself so the body just thinks everything is OK as the cancer grows unchecked.

Before this gets slammed into health forum, let the masses who visit "Current Events" have a shot at reading it and discussing it? Sort of like the moderators' contribution to saving lives as the word spreads?

I lost several family members and friends to cancer. They would've liked to have known about this awhile back. However, vaccines and how they work have been known about for some time. With viruses, they used a modified live virus often, one that isn't deadly but is so close that it trains the immune system to attack the real deal. Also they use killed virus with similar effects of recognition. Seems someone's thinking cap could've been on a long time ago about this one.

True they have to sample tumors from each individual patient because of the wide variation in mutated dna intrinsic to each type of cancer and patient in which it sits. But I think they could streamline the process and get 'er done. It might cut into chemo $$ though. Might be the reason the US is dragging ass.

Discuss.

you act as if there is only one type of cancer

in order to be successful there will have to be many cures found

chemo is cheap

compared to my biologic

which runs 32 grand every 21 days

You're right - now. Likely for a long time.

But there's promise there.

Cell phones used to cost thousands of dollars, and have weights measured in pounds.

 

[fncceo]

A cure for cancer is potentially the highest grossing pharmaceutical in history.

Cancer vaccines and antibody delivery systems are soon expected to 25% of pharmaceutical revenues in the next decade.

If you’re suggesting that pharmaceutical companies risk that revenue by releasing drugs without sufficient human trials, I have one word for you.

Thalidomide.

 

[Silhouette]

There has to be something more to it. I don't see big Pharma wanting to cure it since it is a multi billion dollar making business . To have a vaccine for it Hmmm they've got something up their sleeves. I sure in the hell wouldn't trust this bs.

These same bastards gave people potion via a vaccines a few decades ago, they've had HIV virus in some other batch of vaccines....

Big Pharma is to dam crooked.

Compared to the $$ BigPharma makes off of chemo, a one shot vaccine made in a local lab is going to cut deep into their profits. Your scare tactics are noteworthy though. Does it bother you that you may be costing human life whoring for BigPharma like that?

 

[Silhouette]

I've read some articles on this. It's promising, but far from a miracle cure.

The biggest issue is that there are hundreds of different types of cancer, all of which attack the body in different ways. All of these tests have focused on melanoma - a terrible disease - but only one of hundreds.

The whole "big pharma" conspiracy stuff is nonsense - there are a lot of pharmaceutical companies that don't make chemo drugs - any of them would love to own the cure for cancer.

The theory is sound for any type of solid tumor That's why it's called "personalized" vaccine. They create a vaccine for each patient by using that patient's unique tumor cells.