Probably life exists everywhere it can, just as on earth. Probably we will never make contact with intelligent life elsewhere due to all the obvious elements of vast time and space. Absolutely, it makes no existential difference. The presence or absence of others changes nothing about the essential questions of "being" for the individual. In a way, we are, each of us, alone and isolated in our unique, personal envelop of flesh and mind. We see and hear and believe that it is real, yet our dreams reveal that it could all, also, be a dream. That can be pleasant or unpleasant to contemplate, as one chooses, but it need not be. Most of all, it would not be changed simply by knowing that there appears to be other life forms who have the same situation.