You might take a look at the debates in the Virginia Ratifying Convention regarding Article I, Sec 8, Cl 15 between Patrick Henry and George Mason on one side and James Madison and John Marshall on the other-- I believe the debate occurs on or about June 17, 1788 IIRC. Then take a look at St George Tucker's Blackstone on the same article found in the appendix. You might look at the 10th with a different perspective....
You might want to look at the case law concerning 10th Amendment claims, as the Constitution exists solely in the context of its case law:
“The [Tenth A]mendment states but a truism that all is retained which has not been surrendered. There is nothing in the history of its adoption to suggest that it was more than declaratory of the relationship between the national and state governments as it had been established by the Constitution before the amendment, or that its purpose was other than to allay fears that the new national government might seek to exercise powers not granted, and that the states might not be able to exercise fully their reserved powers.
[...]
From the beginning and for many years, the amendment has been construed as not depriving the national government of authority to resort to all means for the exercise of a granted power which are appropriate and plainly adapted to the permitted end.”
United States v. Darby | US Law | LII / Legal Information Institute
Consequently, the Tenth Amendment does not 'authorize' the states to 'ignore' or seek to 'nullify' Federal law or the rulings of Federal courts. The states have no 'authority' to decide what is Constitutional and what is not, as that is the sole purview of the Federal courts.
And this is indeed the original intent of the Founding Generation: that Federal laws, the Federal Constitution and its case law, and the rulings of Federal courts are the supreme law of the land, binding on the states and local jurisdictions, safeguarding the rights of the American citizens who reside in the states, whose rights are neither subject to 'majority rule' nor the 'will of the people':
This Constitution, and the Laws of the United States which shall be made in Pursuance thereof; and all Treaties made, or which shall be made, under the Authority of the United States, shall be the supreme Law of the Land; and the Judges in every State shall be bound thereby, any Thing in the Constitution or Laws of any State to the Contrary notwithstanding.
Article VI, US Constitution