#19: The current Haaretz report cannot verify for sure whether it was partial or complete two-dose vaccination in each host. We must intervene before continuing, with host differences concerning CYP2D6:
Oct 2020 Spain CYP2D6 / SARS-CoV-2
Establishing accurate and large-scale genotype-phenotype correlations and predictions of individual response to pharmacological treatments are two of the <i>holy grails</i> of Personalized Medicine. These tasks are challenging and require an integrated knowledge of the complex processes that...
pubmed.ncbi.nlm.nih.gov
’....The CYP2D6 gene is a vvery well documented case in which large genetic variability is known to affect patients’ phenotype in a complex manner....encodes for cytochrome P450 2D6 monooxygenase, an enzyme involved in the metabolism of a wide variety of biomolecules (such as lipids) as well as several of the most marketed drugs, including SARS-CoV therapies (e.g. chloroquine and hydroxychloroquine)....displays large genetic diversity, including non-sense, frameshift and missense mutations, and gene duplications.’
The geographical location of the host matters:
Ap 2020 Ghost Within A Ghost
G6PD deficiency in the COVID-19 pandemic: Ghost within Ghost
pubmed.ncbi.nlm.nih.gov
’....Up to the time of writing this letter, the association between G6PD deficiency and novel coronavirus (COVID-19) is absent in COVID-19 reports. This absence could be because G6PD deficiency was overlooked during the current COVID-19 pandemic. One may argue that by using hydroxychloroquine to treat COVID-19 was less likely, as hydroxychloroquine needs to be cautiously used in G6PD deficiency. Another reason for this absence could be that G6PD deficiency in the countries most affected by COVID-19 is rare and/or of the mild type....Hydroxychloroquine has oxidative properties that could decrease glutathione levels and may cause severe hemolysis in COVID-19 patients....Mediterranean region, 10% G6PD deficiency....In Hubei Province in China, origin of COVID-19, the incidence of G6PD deficiency is only 0.098% and about 50% are due to WHO Class III mild type.‘
Variations in host metabolism of chloroquine and hcq link to CYP2D6 mutations in vivax malaria in Yunnan Province. Furthermore, vaccine-induced coagulopathies are now under scrutiny for precise amino acids, such as in the Delta variant mutation K417T, which was originally published by the CDC at that position in the P.1 Brazil-Japan variant as K417N/T (K = lysine). They then changed it, eliminating the N (asparagine), which was indeed a clue to glycosylation sites.
Belgium / The Netherlands / Thrombospondin Deficiency / Thrombotic Thrombocytopenic Purpura / Lysine
We propose that plasminogen activation on endothelial cells acts as a natural backup for ADAMTS13 to degrade obstructive platelet-VWF complexes. Our findings indicate that thrombolytic agents may have therapeutic value in the treatment of microangiopathies and may be useful to bypass inhibitory...
pubmed.ncbi.nlm.nih.gov