Well there's one worry the alt-left should carry with them, Trump will not have to toss many more Hail Mary's than he might have had to before this Omnibus Bill. This means, he will look at his promises and say "ok, NAFTA negotiations are stuck in a runt, f it, we're out of that (to cheers from unions, the Rustbelt and many who aren't happy with the deal)."
"The Wall needs to be paid for, you aren't willing to support National Security, govt is shut down until you do"
"We are getting screwed over by the EU, China, Canada, Mexico, South Korea and others. For every tariff they apply to our goods, we will match it, every barrier they place, we will try and meet them as best we can. No more exploitation of America".
On and on, you get the picture. He can no longer play nice and reach across the aisle to those who want the Status Quo, the Status Quo is more than ever his enemy.
He has a tougher climb now, and thus, to inspire voters to support him, he's going to work harder to drain the swamp and govern much closer to his campaign promises than ever before.
That's how I see it, if he is serious about 2018 and 2020. Just consider his recent appointments for CIA, National Security and even his legal team. When he feels threatened or corners he goes into "to hell with Mr. Nice Guy" mode.