- Thread starter
- #1,561
Bringing the science facts forward: an RGD motif occurs at SARS2 spike position 405-407.
RGD Motif / Parkinson's Disease
Jun 2019 Cairo / Hydroxychloroquine / Anti-Parkinson's Potential
'....HCQ successfully ameliorated PD motor dysfunction in spite of the fact that both autophagy and apoptosis were deregulated through Nurr1. modulation.'
@TheJikky 10h+, BioAnon posts about HIV-1 glycoprotein gp120:
@ 11 Dec
When investigating the intriguing fact that Beluga disintegrin is cleaved by both furin and PCSK7, we made an HIV-1 gp160 connection that is comparable with BioAnon's gp120, which Twitter page indeed shows the furin cleavage site in proximity to gp120.
Here is the gp160 study linking PCSK7:
There is a neurocognitive disorder linking HIV-1 infection to Beluga's PCSK7 cleaving, and we have already mentioned thrombin recently in this thread:
2015 HIV-1 Neurocognitive Disorder
'....is cleaved by thrombin....furin and PC7 interact with PAR1....'
Next is a troponin link to azithromycin, recalling that azithromycin physically binds to the SARS2 furin catalytic pocket:
Increased Troponin Levels / Azithromycin
Digressing further on the tropomodulin study that links to amino acid sequences very reminiscent of the SARS2 furin cleavage motif (RRAR) at position 681-4,
Jul 2004 Tropomodulin / Furin-Like Sequences
'....In a transgenic model, overexpression of the Tmod in the heart leads to a dilated cardiomyopathic phenotype. This requirement for stoichiometric stability has led to speculation that regulated tropomodulin expression is necessary to maintain stabilized actin filament structures in cardiac muscle cells.
....
The accumulation of Tmod in the nucleus hampers the normal myogenic process in C2 cells.
....
We have been studying functional peptide domains of the E-Tmod (erythrocyte membranes)....nemaline myopathy....'
So before going into detail about the Tmod sequences similar to furin cleavage sites, this linking report:
1998 Neshiva U., Bronx, New York / HIV-1-Associated Nemaline Myopathy
RGD Motif / Parkinson's Disease
Oxidized/deamidated-ceruloplasmin dysregulates choroid plexus epithelial cells functionality and barrier properties via RGD-recognizing integrin binding - PubMed
Choroid plexus epithelial cells (CPEpiCs) determine the composition of cerebrospinal fluid (CSF) and constitute the blood-CSF barrier (BCSFB), functions that are altered in neurodegenerative diseases. In Parkinson's disease (PD) the pathological environment oxidizes and deamidates the...
pubmed.ncbi.nlm.nih.gov
Jun 2019 Cairo / Hydroxychloroquine / Anti-Parkinson's Potential
Hydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition - PubMed
The nuclear orphan receptor (Nurr1) has recently received a perceivable solicitude as a target for the therapeutic intervention against PD. Meanwhile, the dysregulation of autophagy, along with other processes is believed to contribute massively to PD pathophysiology. Hydroxychloroquine, a...
pubmed.ncbi.nlm.nih.gov
@TheJikky 10h+, BioAnon posts about HIV-1 glycoprotein gp120:
@ 11 Dec
When investigating the intriguing fact that Beluga disintegrin is cleaved by both furin and PCSK7, we made an HIV-1 gp160 connection that is comparable with BioAnon's gp120, which Twitter page indeed shows the furin cleavage site in proximity to gp120.
Here is the gp160 study linking PCSK7:
Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines - PubMed
The human immunodeficiency virus HIV envelope glycoprotein gp160 is synthesized as an inactive precursor, which is processed into its fusiogenic form gp120/gp41 by host cell proteinases during its intracellular trafficking. Kexin/subtilisin-related endoproteases have been proposed to be enzyme...
pubmed.ncbi.nlm.nih.gov
There is a neurocognitive disorder linking HIV-1 infection to Beluga's PCSK7 cleaving, and we have already mentioned thrombin recently in this thread:
2015 HIV-1 Neurocognitive Disorder
Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder - PubMed
The proprotein convertases (PCs) furin, PC5, PACE4, and PC7 cleave secretory proteins after basic residues, including the HIV envelope glycoprotein (gp160) and Vpr. We evaluated the abundance of PC mRNAs in postmortem brains of individuals exhibiting HIV-associated neurocognitive disorder...
pubmed.ncbi.nlm.nih.gov
Next is a troponin link to azithromycin, recalling that azithromycin physically binds to the SARS2 furin catalytic pocket:
Increased Troponin Levels / Azithromycin
Predictive factors for cardiac conduction abnormalities with hydroxychloroquine-containing combinations for COVID-19 - PubMed
This longitudinal, prospective cohort study aimed to assess risk of QTc interval prolongation and its predicting factors in subjects treated with combinations containing hydroxychloroquine (HCQ) for COVID-19. Moderate-to-severe QTc prolongation during therapy was defined as a QTc interval >470 ms …
pubmed.ncbi.nlm.nih.gov
Digressing further on the tropomodulin study that links to amino acid sequences very reminiscent of the SARS2 furin cleavage motif (RRAR) at position 681-4,
Jul 2004 Tropomodulin / Furin-Like Sequences
Cytoplasmic nuclear transfer of the actin-capping protein tropomodulin - PubMed
Tropomodulin (Tmod) is a cytoskeletal actin-capping protein that interacts with tropomyosin at the pointed end of actin filaments. E-Tmod is an isoform that expresses predominantly in cardiac cells and slow skeletal muscle fibers. We unexpectedly discovered significant levels of Tmod in nuclei...
pubmed.ncbi.nlm.nih.gov
....
The accumulation of Tmod in the nucleus hampers the normal myogenic process in C2 cells.
....
We have been studying functional peptide domains of the E-Tmod (erythrocyte membranes)....nemaline myopathy....'
So before going into detail about the Tmod sequences similar to furin cleavage sites, this linking report:
1998 Neshiva U., Bronx, New York / HIV-1-Associated Nemaline Myopathy
Distinct light microscopic changes in human immunodeficiency virus-associated nemaline myopathy - PubMed
The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM...
pubmed.ncbi.nlm.nih.gov