COVID-19’s Biological Politics

[badger2]

Bringing the science facts forward: an RGD motif occurs at SARS2 spike position 405-407.

RGD Motif / Parkinson's Disease

Oxidized/deamidated-ceruloplasmin dysregulates choroid plexus epithelial cells functionality and barrier properties via RGD-recognizing integrin binding - PubMed

Choroid plexus epithelial cells (CPEpiCs) determine the composition of cerebrospinal fluid (CSF) and constitute the blood-CSF barrier (BCSFB), functions that are altered in neurodegenerative diseases. In Parkinson's disease (PD) the pathological environment oxidizes and deamidates the...

pubmed.ncbi.nlm.nih.gov

Jun 2019 Cairo / Hydroxychloroquine / Anti-Parkinson's Potential

Hydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition - PubMed

The nuclear orphan receptor (Nurr1) has recently received a perceivable solicitude as a target for the therapeutic intervention against PD. Meanwhile, the dysregulation of autophagy, along with other processes is believed to contribute massively to PD pathophysiology. Hydroxychloroquine, a...

pubmed.ncbi.nlm.nih.gov

'....HCQ successfully ameliorated PD motor dysfunction in spite of the fact that both autophagy and apoptosis were deregulated through Nurr1. modulation.'

@TheJikky 10h+, BioAnon posts about HIV-1 glycoprotein gp120:

https://twitter.com/TheJikky

@ 11 Dec

https://twitter.com/BioAnon_1vy_

When investigating the intriguing fact that Beluga disintegrin is cleaved by both furin and PCSK7, we made an HIV-1 gp160 connection that is comparable with BioAnon's gp120, which Twitter page indeed shows the furin cleavage site in proximity to gp120.

Here is the gp160 study linking PCSK7:

Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines - PubMed

The human immunodeficiency virus HIV envelope glycoprotein gp160 is synthesized as an inactive precursor, which is processed into its fusiogenic form gp120/gp41 by host cell proteinases during its intracellular trafficking. Kexin/subtilisin-related endoproteases have been proposed to be enzyme...

pubmed.ncbi.nlm.nih.gov

There is a neurocognitive disorder linking HIV-1 infection to Beluga's PCSK7 cleaving, and we have already mentioned thrombin recently in this thread:

2015 HIV-1 Neurocognitive Disorder

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder - PubMed

The proprotein convertases (PCs) furin, PC5, PACE4, and PC7 cleave secretory proteins after basic residues, including the HIV envelope glycoprotein (gp160) and Vpr. We evaluated the abundance of PC mRNAs in postmortem brains of individuals exhibiting HIV-associated neurocognitive disorder...

pubmed.ncbi.nlm.nih.gov

'....is cleaved by thrombin....furin and PC7 interact with PAR1....'

Next is a troponin link to azithromycin, recalling that azithromycin physically binds to the SARS2 furin catalytic pocket:

Increased Troponin Levels / Azithromycin

Predictive factors for cardiac conduction abnormalities with hydroxychloroquine-containing combinations for COVID-19 - PubMed

This longitudinal, prospective cohort study aimed to assess risk of QTc interval prolongation and its predicting factors in subjects treated with combinations containing hydroxychloroquine (HCQ) for COVID-19. Moderate-to-severe QTc prolongation during therapy was defined as a QTc interval >470 ms …

pubmed.ncbi.nlm.nih.gov

Digressing further on the tropomodulin study that links to amino acid sequences very reminiscent of the SARS2 furin cleavage motif (RRAR) at position 681-4,

Jul 2004 Tropomodulin / Furin-Like Sequences

Cytoplasmic nuclear transfer of the actin-capping protein tropomodulin - PubMed

Tropomodulin (Tmod) is a cytoskeletal actin-capping protein that interacts with tropomyosin at the pointed end of actin filaments. E-Tmod is an isoform that expresses predominantly in cardiac cells and slow skeletal muscle fibers. We unexpectedly discovered significant levels of Tmod in nuclei...

pubmed.ncbi.nlm.nih.gov

'....In a transgenic model, overexpression of the Tmod in the heart leads to a dilated cardiomyopathic phenotype. This requirement for stoichiometric stability has led to speculation that regulated tropomodulin expression is necessary to maintain stabilized actin filament structures in cardiac muscle cells.
....
The accumulation of Tmod in the nucleus hampers the normal myogenic process in C2 cells.
....
We have been studying functional peptide domains of the E-Tmod (erythrocyte membranes)....nemaline myopathy....'

So before going into detail about the Tmod sequences similar to furin cleavage sites, this linking report:

1998 Neshiva U., Bronx, New York / HIV-1-Associated Nemaline Myopathy

Distinct light microscopic changes in human immunodeficiency virus-associated nemaline myopathy - PubMed

The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

I sent you a few details in your inbox. Any info specifically to share or retrieve just let me know. The account is very active.

Have never visited the box, though will do it to read the details.

 

[badger2]

Yes, thanks. Those details were noticed. TheJikky somewhere states the London School of Hygiene and Tropical Medicine as being linked to Team Halo.

So, furin is a subtilisin-like proprotein convertase:

A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2 - PubMed

Currently, the world is facing a pandemic of the new coronavirus SARS-CoV-2 that causes COVID-19. Identifying key targets in the viral infection lifecycle is urgently needed for designing therapeutic strategies to combat the virus. Furin is a subtilisin-like proprotein convertase with diverse...

pubmed.ncbi.nlm.nih.gov

A 'subtilisin-like' Pubmed search retrieved the Team Halo connection, which is a Gates Foundation connection to malaria, automatically linking HCQ:

Sep 2022 London School of Hygiene and Tropical Medicine / Subtilisin-Like / Malaria

Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery - PubMed

Widespread resistance to many antimalarial therapies currently in use stresses the need for the discovery of new classes of drugs with new modes of action. The subtilisin-like serine protease SUB1 controls egress of malaria parasites (merozoites) from the parasite-infected red blood cell. As...

pubmed.ncbi.nlm.nih.gov

The previous month, China:

Aug 2022 / China / PCSK9 Subtilisin-Like Kexin Type 9

Ocular disorders associated with PCSK9 inhibitors: A pharmacovigilance disproportionality analysis - PubMed

This pharmacovigilance study identified a possible signal of ocular disorders associated with PCSK9 inhibitors and encourages paying attention to at-risk populations in PCSK9 inhibitors medication.

pubmed.ncbi.nlm.nih.gov

'....lipid-lowering agents....'

The anti-SARS2 effects of such statins as rosuvastatin link to this lipid-lowering phenomenon of PCSK9.

 

[ClaireH]

This is from Jikky:

 

[badger2]

This is from Jikky:

Claire, thank you. You boldly went where no man has gone: smuggling a USMB photo into the Twitter concentration camp. Hope it was successful, we reading them, they reading us.

There seems to be no RGD sequence in the SARS1 spike, and what Twitterists may want to notice is that what coronavirologists knew in 2008 about Parkinson's (post #1,540) links to Dr. Quay's page we first noticed the RGD sequence of the Chinese military virus ZC45. ZC45 is doing the same thing that 229E does, especially noting the deletions after the RGD sequence:

Dr. Quay's Twitter page 24 Aug 2022
ZC45 sequence: RGDP---, (3 amino acid deletions)

HCov-229E, mentioned in the PD post (#1, 540), positions 341-343: RGDCKG----- (5 amino acid deletions)

This could be a modus operandi of the virus rather than a coincidence.

Twitterist Brook Jackson's inquiry about Pfizer's hidden troponin results may link genetically to those who are more susceptible to the coronavirus spike than other "vaccinees." How valid is the troponin-tropomodulin assemblage?

 

[badger2]

We have found another PD link. The Twitterist was suspended:

https://twitter.com/ssayssayssay

'@ 22h Dr. Stephanie Seneff (permanently suspended from Twitter for much of 2022)....and neurological disorders such as Parkinson's and Alzheimer's....'

 

[badger2]

Bearing in mind that ZC45 Chinese military virus is neurotropic in rats and considering the Parkinson's excerpt (post #1,540), we should cite the references as they occur in the body of the text. Thusfar, we see no RGD motifs in OC-43 or bovine coronavirus spikes.

postencephalitic parkinsonism (35. Fishman PS et al, (1985) Infection of the Basal Ganglia by a Murine Coronavirus, Science 229:877).

a report of antiviral antibodies (34. Fazzini E. et al, (1992) Cerebrospinal Fluid Antibodies to Coronavirus in Patients with Parkinson's Disease, Mov. Disord. 7:155)

and HCoV RNAs (23. Cristallo A, et al (1997) Human Coronavirus Polyadenylated RNA Sequences in Cerebrospinal Fluid from Multiple Sclerosis Patients, New Microbiol. 20:105)

three out of three were positive for HCoV-229E, one for HCoV-OC-43 (5. Arbour N, et al, (2000) Neuroinvasion by Human Respiratory Coronaviruses and Association with Multiple Sclerosis, J. Virol. 74: 8913).

Outside this excerpt, the link to bovine coronavirus, which may have jumped into humans: p. 314 'Thus, HCoV-OC43 could be a human-adapted strain of BCoV (108.Vijgen L, et al (2005) Complete Genomic Sequence of Human Coronavirus OC-43: Molecular Clock Analysis suggests a Relatively Recent Zoonotic Coronavirus Transmission Event, J. Virol. 79: 1595)

 

[ClaireH]

Because we are unable to communicate with Twitter, those who can may wish to smuggle in a photo of USMB to show them. USMB keyword search function may be of assistance to those Twitterists interested in specific terms.

Here is a most revealing chain of emails that Fauci would have preferred they stay hidden. Thankful to the efforts of non-corrupt journalists doing the necessary leg work we can learn using primary documents of Fauci’s trickery.

Fauci Emails Show Doctor Who Rose To Fame To Cover His Own Scandal

More than 3,200 pages of emails dated from January to June 2020 reveal the portrait of a government bureaucrat operating as a government bureaucrat.

thefederalist.com

Edit- this is running on Twitter currently with numerous shares btw.

 

[ClaireH]

Claire, thank you. You boldly went where no man has gone: smuggling a USMB photo into the Twitter concentration camp. Hope it was successful, we reading them, they reading us.

There seems to be no RGD sequence in the SARS1 spike, and what Twitterists may want to notice is that what coronavirologists knew in 2008 about Parkinson's (post #1,540) links to Dr. Quay's page we first noticed the RGD sequence of the Chinese military virus ZC45. ZC45 is doing the same thing that 229E does, especially noting the deletions after the RGD sequence:

Dr. Quay's Twitter page 24 Aug 2022
ZC45 sequence: RGDP---, (3 amino acid deletions)

HCov-229E, mentioned in the PD post (#1, 540), positions 341-343: RGDCKG----- (5 amino acid deletions)

This could be a modus operandi of the virus rather than a coincidence.

Twitterist Brook Jackson's inquiry about Pfizer's hidden troponin results may link genetically to those who are more susceptible to the coronavirus spike than other "vaccinees." How valid is the troponin-tropomodulin assemblage?

Your precise info will be shared using your links to studies on Twitter directed to Jikky’s feed for his numerous followers.

 

[badger2]

Here is a most revealing chain of emails that Fauci would have preferred they stay hidden. Thankful to the efforts of non-corrupt journalists doing the necessary leg work we can learn using primary documents of Fauci’s trickery.

Fauci Emails Show Doctor Who Rose To Fame To Cover His Own Scandal

More than 3,200 pages of emails dated from January to June 2020 reveal the portrait of a government bureaucrat operating as a government bureaucrat.

thefederalist.com

Edit- this is running on Twitter currently with numerous shares btw.

This dynamic is just what's needed to reveal the fraud. Jikky has mentioned some unfamiliar names. Must read.

 

[badger2]

Your precise info will be shared using your links to studies on Twitter directed to Jikky’s feed for his numerous followers.

This is great news. The legwork is very much appreciated.

 

[badger2]

For Brook Jackson's troponin questions to Pfizer (above), we should add these studies:

Feb 2022 Russia: Troponin False Positives

False-Positive Causes in Serum Cardiac Troponin Levels - PubMed

Cardiac troponins (cTns) are the most valuable and specific markers of cardiovascular diseases, including acute myocardial infarction. These biomarkers can also be used to assess the degree of myocardial damage in non-cardiac diseases that can negatively affect the cells of cardiac muscle...

pubmed.ncbi.nlm.nih.gov

'....fibrin clots, heterophilic antibodies, alkaline phosphatase, rheumatoid factor, cross-reactions with skeletal troponins....'

Recalling the previous link made to phlebovirus fibrin clots:

27 Nov 2022 Post #77 Phlebovirus Fibrin Clots

DIED SUDDENLY - Full Documentary

Yes, us smart people have gotten vaxxed, worn masks and social distanced as sensibly called for without complaint. Even your hero Trump got vaxxed and you know you'd never be allowed to bet anything of substance so stop kidding yourself, wanker. Grow up and try to enjoy social life for a change...

www.usmessageboard.com

'....intravascular fibrin deposition.'

Sandflies vector phleboviruses. VSV-based ebola vaccine links sandfly genus Lutzomiya, a vector of VSV. The precise SARS2 mutation that links increased VSV pseudoparticle production is D614G, the mutation Fau Chi gets backwards in his video (freudian slip).

The Science Underlying COVID-19: Implications for the Cardiovascular System - PubMed

The coronavirus disease 2019 (COVID-19) pandemic has affected health and economy worldwide on an unprecedented scale. Patients have diverse clinical outcomes, but those with preexisting cardiovascular disease, hypertension, and related conditions incur disproportionately worse outcome. The high...

pubmed.ncbi.nlm.nih.gov

'....acquisition of a furin cleavage site....reflected in the release of highly sensitive troponin and natriuretic peptides, which are extremely prognostic, in particular, those showing continued rise, along with cytokines such as IL-6.'

 

[badger2]

We can adjust the chron that links the RGD motifs of the PLA's virus, ZC45, and HCoV-229E, back to 1967.

'The Pre-SARS Era: HCoV-229E and HCoV-OC43.....Recent phylogenetic analysis based on the spike (S) and nucleocapsid (N) protein genes of HCoV-229E revealed that several different variants, causing different types of respiratory tract infections, were isolated from patients in Australia between 1979 and 2004. The sequencing and analysis of these HCoV-229E variants strongly suggested genetic drift had occurred. However, the similarity among these variants circulating in Australia and other strains identified in other geographical locations during the same period revealed that HCoV-229E has not undergone major recombination since its isolation in 1967. (20. Chibo D, et al (2006) Analysis of Human Coronavirus 229E Spike and Nucleoprotein Genes Demonstrates Genetic Drift Between Chronologically Distinct Strains, J. Gen. Virol. 87:1203).'
(Nidoviruses, ASM Press [2008] p.314)

 

[ClaireH]

Attached is a tweet from Jikky.

 

[badger2]

Attached is a tweet from Jikky.

Yes, Fau Chi and Gates knew that azithromycin physically attached to the fruin catalytic pocket, directly competing with their "vaccines." Fau Chi then removed azithromycin, as Jikky documents @Twitter. The evidence-based science is here:

Comparative Computational Analysis of Dirithromycin and Azithromycin in Search for a Potent Drug against COVID-19 caused by SARS-CoV-2: Evidence from molecular docking and dynamic simulation - PubMed

Due to the emergency and uncontrolled situation caused by the COVID-19 pandemic that arising in the entire world, it is necessary to choose available drugs that can inhibit or prevent the disease. Therefore, the repurposing of the commercial antibiotic, dirithromycin has been screened for the...

pubmed.ncbi.nlm.nih.gov

 

[badger2]

We bring this forward especially for the Twitterists, because of what many of them have written about zoonoti Worobey and the Huanan Seafood Market hypothesis. It seems that they did not know about Worobey and the coelacanth, which also links another ancient fish, Myllokunmingia from Kunming, Yunnan and also links two co-authors of each other, EC Holmes and Yong-Zhen Zhang (Beijing CDC). The Kunming Institute of Zoology links these co-authors and Kunming Hospital is where the ill Mojiang miners were admitted.

Post #1,537 Worobey-Han and Coelacanth Foamy Virus

COVID-19’s Biological Politics

Washington Officials Traded Stocks with Exquisite Timing https://twitter.com/R_H_Ebright

www.usmessageboard.com

Fau Chi's NIH is linked to this:

Canine Foamy Virus Vector / CD18 Integrin / CLAD

Foamy virus vectors come of age - PubMed

Foamy virus vectors come of age

pubmed.ncbi.nlm.nih.gov

Human LAD / NIH

Preclinical Evaluation of Foamy Virus Vector-Mediated Gene Addition in Human Hematopoietic Stem/Progenitor Cells for Correction of Leukocyte Adhesion Deficiency Type 1 - PubMed

<span><i>Ex vivo</i> gene therapy procedures targeting hematopoietic stem and progenitor cells (HSPCs) predominantly utilize lentivirus-based vectors for gene transfer. We provide the first pre-clinical evidence of the therapeutic utility of a foamy virus vector (FVV) for the genetic correction...

pubmed.ncbi.nlm.nih.gov

Human foamy has an RGD motif at positions 294-6

UniProt

uniprot.org

So for the CD18 integrins....

Participation of CD11a-c/CD18, CD2 and RGD-binding receptors in endogenous and interleukin-2-stimulated NK activity of CD3-negative large granular lymphocytes - PubMed

The effect of RGD-sequence-containing pentapeptides and monoclonal antibodies (MAbs) against the adhesion molecules CD11a-c/CD18, ICAM-1 (CD54) and CD2 on the binding and cytotoxicity of endogenous (freshly purified) and IL-2-stimulated CD3-negative NK cells has been studied. Antibody to CD18...

pubmed.ncbi.nlm.nih.gov

'....The RGD-peptide substantially inhibited the binding of IL-2-stimulated killer cells to COLO (adenocarcinoma cell line), and the combination of this peptide with Mabs to CD18, CD54, and CD2 practically blocked the adhesion.'

 

[ClaireH]

More evidence that testing positive for covid prevented standard care, tried and true, for elderly with pneumonia. Many people died because treatment was withheld. This will come out very badly for those making this decision to change protocol. 3 pills- all these patients needed to survive.

https://www.nice.org.uk/guidance/ng191/resources/managing-covid-19-treatments-july-2022-v27.0-pdf-11070542125

 

[ClaireH]

The following link contains study results that were buried, as most know by now along with many others, in order continue the false covid narrative.

Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2

To prevent future pandemics, it is important that we understand whether SARS-CoV-2 spilled over directly from animals to people, or indirectly in a laboratory accident. The genome of SARS-COV-2 contains a peculiar pattern of unique restriction endonuclease recognition sites allowing efficient...

www.biorxiv.org

 

[badger2]

More evidence that testing positive for covid prevented standard care, tried and true, for elderly with pneumonia. Many people died because treatment was withheld. This will come out very badly for those making this decision to change protocol. 3 pills- all these patients needed to survive.

https://www.nice.org.uk/guidance/ng191/resources/managing-covid-19-treatments-july-2022-v27.0-pdf-11070542125

Yes, we see for azithromycin, "not recommended." Azithromycin is a SARS2-specific antiviral antibiotic, and binds into the furin catalytic pocket of SARS2 spike. The virus will then have difficulty in using furin cleavage for any increased infection advantage. This very peculiar furin cleavage site also has the next-to-impossible for naturally occurring CGG for arginine, which is mostly used by those engineering a virus.

 

[badger2]

The following link contains study results that were buried, as most know by now along with many others, in order continue the false covid narrative.

Endonuclease fingerprint indicates a synthetic origin of SARS-CoV-2

To prevent future pandemics, it is important that we understand whether SARS-CoV-2 spilled over directly from animals to people, or indirectly in a laboratory accident. The genome of SARS-COV-2 contains a peculiar pattern of unique restriction endonuclease recognition sites allowing efficient...

www.biorxiv.org

Thanks for this. We will review.