COVID-19’s Biological Politics

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The mite, Notoedres cati, also occurs on another natural reservoir of SARS-CoV:

Racoon Dog (Nyctereutes procyonoides viverrinus) / Notoedres cati

Involvement of two genetic lineages of Sarcoptes scabiei mites in a local mange epizootic of wild mammals in Japan - PubMed

Similar to wild mammals on the continents, mange caused by the mange mite, Sarcoptes scabiei (Acari: Sarcoptidae) is spreading in wild mammals in most of Japan. We collected crusted or alopetic skin from 120 raccoon dogs (Nyctereutes procyonoides viverrinus), three raccoons (Procyon lotor), six...

pubmed.ncbi.nlm.nih.gov

’....The cat mite (Notoedres cati) was the cause in one raccoon dog (Nyctereutes procyonoides viverrinus) and one raccoon.’

Jun 2021 Tel Aviv: Demodicosis / STAT1 Gain-of-Function

Chronic demodicosis in patients with immune dysregulation: An unexpected infectious manifestation of Signal transducer and activator of transcription (STAT)1 gain-of-function - PubMed

Signal transducer and activator of transcription (STAT)1 heterozygous gain-of-function (GOF) mutations are known to induce immune dysregulation and chronic mucocutaneous candidiasis (CMCC). Previous reports suggest an association between demodicosis and STAT1 GOF. However, immune...

pubmed.ncbi.nlm.nih.gov

’....topical ivermectin.’

Jun 2021 Columbia: Shrimp-Mite Allergens

Clinical Relevance of Shrimp Sensitization in Patients with Allergic Rhinitis: Anti-Der p 10 IgE as Predictor - PubMed

Our results suggest that in patients with HDM-associated AR and shrimp IgE sensitization is necessary to evaluate the clinical relevance of shrimp IgE even if the patient has never consumed shrimp because of cross-reactivity. Anti-Der p 10 could be a possible biomarker of clinical relevance to...

pubmed.ncbi.nlm.nih.gov

’....In tropical region, shrimp (5-15%) and mite sensitization (85-95%) is prevalent in allergic patients.’

Shrimp and mite cross-reactivity are a well-known, traditional duo.

A 47-year old human case from Marseille goes beyond shrimp and mites:

2021 Marseille, France: Beyond Shrimp and House Dust Mite Cross Reactivity

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For the evolution of the Nidoviruses, black tiger shrimp link to Australian fauna:

Dec 2020 Australia, Singapore: Black Tiger Shrimp (Penaeus monodon)

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‘Molecular Biology and Pathogenesis of Roniviruses.

Currently, all available information on the Roniviridae has come from studies of yellow head virus (YHV), gill-associated vvirus (GAV, and genotypic variants of these viruses detected in disparate populations of the black tiger shrimp species, Penaeus monodon. These viruses are very closely related and are currently classified as the type species Gill-associated virus of the genus Okavirus.
....
The natural distribution of P. monodon and the genetic relationships of YHV complex of viruses from different geographic locations suggests an association that may predate the tectonic drift that dispersed the Gondwanaland supercontinent some 260 million years ago. This is consistent with the ancient origins and evolutionary conservation of penaeid shrimp, for which Triassic fossils have been discovered in Madagascar; examples of the genus Penaeus have been reported to date to the late Cretaceous period. Moreover, the okavirus genome organization and RNA transcription strategy are relatively simple compared to those of vertebrate nidoviruses, which appear to have evolved in increasing complexity to adapt to higher-order vertebrate hosts. Thus, okaviruses might be regarded as primitive time capsules that provide unique insights into aspects of nidovirus evolution.’
(Cowley JA, Walker PJ, Molecular Biology and Pathogenesis of Roniviruses, in Nidoviruses, op cit, Ch. 24)

 

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Continuing on the allergy trajectory, an Italian study then goes beyond tropomyosin to link Wuhan, China, linking back to hyperosthosis and calcium signaling in Australian wombats mentioned previously:

Sep 2014 Italy: Shrimp Allergy: Beyond Tropomyosin / Arginine Kinase / Sarcoplasmic Calcium-Binding Protein / Hemocyanin

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Huazhong University of Science and Technology, Wuhan, China / Sarcoplasmic Binding Protein (SERCA2a) / Doxorubicin-Induced Cardiotoxicity. / AA9 (adenovirus associated virus serotype 9) Vector-Based Overexpression

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Same Wuhan location, different authors:

Doxorubicin / SARS-Cov-2

Nanomedicine for acute respiratory distress syndrome: The latest application, targeting strategy, and rational design - PubMed

Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of the lung air-blood barrier, leading to irreversible and substantial respiratory function damage. Patients with coronavirus disease 2019 (COVID-19) have been encountered with a high risk of...

pubmed.ncbi.nlm.nih.gov

 

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This Catholic-CIA puppet has now become mouthpiece for the CDC. Give the dumb bastard a pop quiz about mutations of the Delta variant, and he will fail it.

18 Jun 2021 Biden Says

Biden says the Delta variant - set to become the US's dominant strain - is 'particularly dangerous for young people'

Young people who are unvaccinated and socially active may be particularly susceptible to a Delta infection.

www.yahoo.com

 

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For readers who may wish to jump ahead in the investigation, we mentioned Marie Bashir Institute, linking to the Mengla tiger and Bronx Zoo tiger, in posts #481-2 of this thread. The Mengla filovirus (ebola and Marburg virus family) from Rousettus fruit bat now links to an American adenovirus via Marie Bashir, Australia, and Chinese COVID-19 vaccine is vectored by an adenovirus:

COVID-19’s Biological Politics

We have already noted Mengla filovirus found in Rousettus in Mengla County, Yunnan, and linked it in that county to the extermination of the last indochinese tiger. The COVID-19-infected Bronx Zoo tiger we compared with the Thylacoleonids, including Wakaleo vanderleuri from the Etadunna...

www.usmessageboard.com

2017 USA Bat Adenovirus

Evolution and Cryo-electron Microscopy Capsid Structure of a North American Bat Adenovirus and Its Relationship to Other Mastadenoviruses - PubMed

Although many adenoviruses are host specific and likely codiverged with their hosts over millions of years, other adenoviruses appear to have emerged through successful cross-species transmission events on more recent time scales. The wide geographic distribution and genetic diversity of...

pubmed.ncbi.nlm.nih.gov

’....Marie Bashir Institute for Infectious Diseases and Biosecurity, Sydney, NSW, Australia.’

 

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The report in post #505 states: ‘In Vitro Host Range: In particular, titers over 10(7) TCID50/ml were observed in primate (monkey), carnivore (dog, fox), and marsupial (opossum) cells over the 10-day time course....Corynorhinus rafinesquii....Kentucky.’

Adenoviruses have been used in HIV-1 and ebola vaccines. Because in some cases pre-existing immunity can cause more, not less susceptibility to viruses, Fauci’s claim in a 2015 paper that this phenomenon in HIV-1 vaccines was likely unique, the following report questions the uniqueness:

19 Oct 2020 The Lancet, Use of Adenovirus Type-5 Vectored Vaccines: A Cautionary Tale

Use of adenovirus type-5 vectored vaccines: a cautionary tale - PubMed

Use of adenovirus type-5 vectored vaccines: a cautionary tale

pubmed.ncbi.nlm.nih.gov

We can now link previous messages to Demodex found on the masked palm civet and other SARS-CoV reservoirs:

(2016) Corynorhinus / Demodex

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No doubt, Rand Paul should ask Fauci more about vaccines.

 

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On the snake meat thread, we mentioned that retroviral env elements can naturally integrate into the coronavirus genome.

The Lancet article in post #506 reads, ‘....risk of penile acquisition in men who were uncircumsized....unprotected insertive anal sex....Both studies involved an Ad5 construct that did not have the HIV-1 envelope.....In another study, a DNA prime followed by an Ad5 vector were used, in which both constructs contained the HIV-1 envelope.’

Returning to the cat trajectory for marsupial lions, mountain lions and Bronx Zoo tigers, we mentioned integrated FeLV elements on 24 Sep 2020, post # 1, 042:

Snake Meat......source of chinese virus

The software keeps trying to spell p.i.c.t.a “correctly” as Picts, which is the name of a people in Scotland. The fingerprint characteristics we can agree on to the extent that retroviral env elements can integrate into the coronavirus genome. We are still not buying the lab-escapee scenario...

www.usmessageboard.com

’....certain recombinants harboring an altered primary neutralizing epitope in the middle of the SU (envelope glycoprotein) corresponding to the endogenous FeLV sequence can evade immunity developed against common FeLv infection....Up to three fourths of exogenous FeLV envelope glycoprotein....can be replaced by sequences from an endogenous FeLV to produce biologically active chimeric FeLVs. In vitro replication efficiency or cell tropism of the recombinants appears to be influenced by the amount of SU sequences replaced by the endogenous partner, as well as the locus of origin of the endogenous sequences.’

 

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So, the lab-leak conspiracies touting HIV-1 elements in COVI–19 amino acid sequences are based on natural occurrences.

 

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We’ll connect bat MHC I to marsupial MHC I, and bat filovirus reservoir, Rousettus. Listing the contributors to the study....

Sep 2019 Division of HIV/AIDS and Sex Transmitted Virus Vaccines, Beijing; Duke-NUS Medical School, Singapore; University of Macau; Laboratory of Virology, Beijing; Laboratory of Pathogenic Microbiology and Immunology, Beijing

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’....Notably, features of bat MHC I may be shared by MHC I from various marsupials....koala....Tammar wallaby....Tasmanian Devil....Rousettus aegyptiacus 3-5 amino acid insertion....’

We’ve already mentioned Trichosurus vulpecula in anatomical comparison to the Wakaleo marsupial lion in this thread:

(1996) Intestinal Contents of Trichosurus vulpecula, Massey University, Palmerston North, New Zealand

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’Adenovirus was identified in six samples, herpesvirus in two samples, coronavirus in four samples, and corona-like viruses in 14 samples.’

 

[badger2]

The FIPV coronavirus in cats, dogs and brush-tailed possum, Trichosurus vulpecula, links to chloroquine resistant malaria:

Ap 2020 U. of Sydney, Australia / U. Of Sao Paulo, Brazil
Mefloquine / FIPV / Trichosurus

https://pubmed.ncbi.nlm.nih.gov/322877278

’....Mefloquine, a human anti-malarial agent, has been shown to inhibit FIPV in vitro....used for both prevention and treatment of chloroquine-resistant Plasmodium falciparum malaria in humans....mefloquine was also incubated with microsomes from Trichbosurus vulpecula, as this species of possum is recognized as a rapid xenobiotic metabolizer.’

 

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Coronaviruses and Arteriviruses comprise the Nidoviruses. Pelodiscus soft-shelled turtle was mentioned in the snake meat thread.

Trionyx (Pelidiscus) Hemorrhagic Syndrome Arterivirus / Lung

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Pelodiscus (Trionyx) / SARS-Cov-2

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[badger2]

The fear-mongering by the Catholic-CIA puppet in the White House as well as the media must be deciphered. When the CIA goes to church, it’s not to pray for rain, but to study techniques of crowd control.

We’ll take a closer look at the Delta variant as well as variants of other Nidoviruses, keeping in mind that Delta mutations arose in the (Indian [italics]) genome as host, not any other particular genome as host, even though Delta has some of the same mutations as other variants. That is the confusion that is fueling the current confusion and CIA-sponsored propaganda. We say CIA rather than FBI due to the painting hanging in the White House dining room, mentioned earlier in the thread.

Note that B.1.617.2 is the second earliest (from Dec 2020):

Indian Delta Series and Their Mutations

B.1.617 L452R (also a California, USA mutation), E484Q, D614G, Feb 2021

B.1.617.1 T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1070H, Dec 2020

B.1.617.2 T19R, G142D, 156del, 157del, R158G, L452R, D950N, Dec 2020

B.1.617.3 T19R, G142D, L452R, E484Q, D614G, P681R, D950N, Oct 2020, Oct 2020

We will now compare mefloquine use (posts #510-11) in FIPV with mutations that occur in the FIPV genome.

 

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Anne Laudisoit is the Eco Health Alliance connection in the Congo to this June 2021 report:

Congo Coronavirus Surveillance

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Chinese vaccines use an adenovirus vector (Ad5), linking to the first bat adenovirus in U.S., the Kentucky bat previously mentioned.

22 Jun 2021 Chinese Vaccine Fail

China's COVID vaccine fail: The country's shots may be ineffective at preventing virus spread

Multiple countries that eagerly inoculated their people with China's COVID vaccines face devastating new case surges.Why it matters: This revelation undermines China’s vaccine diplomacy, which Beijing has prioritized in the developing world to win influence and commercial deals.Stay on top of...

news.yahoo.com

 

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With Angiostrongylus cases now occurring in dogs in the UK, previously mentioned was the lungworm in giant panda, the article does not name the lungworm and the cited Chinese-language article, which likely does name the lungworm, is unavailable.

Already mentioned was Daszak’s lungworm article linking the London Zoo.

There is an amino acid sequence for retroviral elements, having already mentioned Trichosurus Wobbly Possum Disease Virus (WPDV), a neurotropic Nidovirus.

Mar 2001 Trichosurus Genome Type D Env Retroviral Element

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’....suggests recent (or ongoing) retrotranscriptional activity
....
Env signaling peptide: MISTLLISLLLFAETDA
....Type D retroviruses had, until recently, been observed only in primates....type D recently found in mice....’

Having already mentioned CEACAM1 in this thread, coronavirus brain invasion is documented, here:

MHV / Brain Invasion

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’....Since all MHV strains use the same cell receptor (CEACAM1), and both MHV3 and MHV-A59 can bind to BMECS (brain microvascular endothelial cells), another factor may be involved in BBB (blood brain barrier) invasion according to MHV serotype....We demonstrate here that the highly hepatotropic MHV3 strain, but not the MHV-A59 of 51.6-MHV3 variant, elicited an in vivo and in vitro breakdown of functional and structural integrity of the BBB, enabling viral invasion of the brain.’

We’ve already linked the Blumberg Foundation to TGEV coronavirus in the snake meat thread, Blumberg (NASA Astrobiology) having discovered the Australian antigen of hepatitis B virus.

Since Blumberg used an antiviral compound from the mulberry tree, we’ll add the RGD motif to this investigation:

Mar 2020 Non-Mulberry RGD Endothelial Barrier

In Vitro Culture of Human Corneal Endothelium on Non-Mulberry Silk Fibroin Films for Tissue Regeneration - PubMed

Development of a suitable carrier for engineering the CE to address a major clinical requirement of healthy donor tissues for transplantation.

pubmed.ncbi.nlm.nih.gov

’....natural cell binding RGD motif....’

Yesterday, this writer found an RGD motif in the spike protein of FIPV, a virus that also infects Trichosurus....tbc...

 

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Tracking coagulopathies, from Promedmail, a lungworm map:

Lungworm Map | My Pet and I

Enter your location below to see the number of cases of lungworm caused by Angiostrongylus vasorum reported in your area. Lungworm is potentially deadly to dogs

uk.mypetandi.com

....abnormal clotting, coughing, breathing problems, changes in behaviour, reluctance to exercise, poor appetite, weight loss....The larvae can be found in mollusc’s slime trails, meaning dogs are at risk if they cross their path....If you spot slugs and snails in your garden or local parks, then be extra vigilant when out with your dog.’

The lungworm infection of giant panda in China links this scenario precisely to masked palm civets entering their dens, undoubtedly coming into contact with their lungworms.

We note the deletions in the Delta variant of COVID-19, at positions 156 and 157, comparing this with MHV coronavirus:

’Various mutations and deletions in the MHV hypervariable region (HVR) have been associated with neuroattenuation. Tp specifically examine the role of HVR in pathogenesis and neurovirulence we generated a series of recombinant viruses....del434-575....MHV HVR 488-600....The most striking difference between the two spikes is that the MHV A59 spike contains a deletion of 52 amino acids in the hypervariable region relative to MHV-4....The MHV-4 was not sufficient, however, too confer increased neurovirulence as demonstrated by the similar virulence of S A59 HV-4R51 and S A59 R16. Furthermore, these data suggest that the MHV-A59 spike can tolerate manipulations within the HVR with little effect on neurovirulence.’
(Joanna J. Phillips, Susan R. Weiss, MHV Neuropathogenesis: Study of the Chimeric S Genes and Mutations in the Hypervariable Region, in The Nidoviruses: Coronaviruses and Arteriviruses)

 

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That was human coronavirus 229E rather than FIPV (feline infectious peritonitis virus), that carries the RGD motif at positions 341-343. Interestingly, this RGD motif occurs just prior to a 5 amino-acid deletion in hCov-229E, and there are corresponding deletions in the proposed HVRs of some of these 8 comparative coronaviruses:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095789/bin/41591_2004_BFnm1024_MOESM4_ESM.pdf

 

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Comparing ACE-2 with SARS-CoV-2:

Proximal Origins of SARS-CoV-2

The proximal origin of SARS-CoV-2 - Nature Medicine

www.nature.com

’....
Ace2

Y442
L472
N479
D480
T487
Y491

corresponds to

SARS-CoV-2

L455
F486
Q493
S494
N501
Y505
....’

Comparing mutations from post #513, we note B.1.617.1 and the Q1070H mutation. In genomic comparisons (post #518) the FIPV spike @1070 is V (valine), and for HCoV-NL63, it is I (isoleucine. In SARS-CoV, that position reads A (alanine), so SARS-CoV-2 substitutes a histidine for what was an alanine. Note the use of branched-chain aminos: valine, leucine and isoleucine.

For the important ebola-vaccine-linking mutation @ position 614, it is Q (glutamine) for FIPV, D for SARS-CoV, G for HCoV-NL63, and G for the Indian variants. The Delta variant (B.1.617.2) mimics HCoV-NL63, as does other SARS-CoV-2 variants.

 

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The RGD motif in COVID-19 links to the N501Y mutation in several C-19 variants (S. Africa, Brazil, UK):

Jan 2021 COVID-19 RGD Motif

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’....N501Y....’

There is no available genome sequences for Trichosurus, although it does vector Mycobacterium bovis from cattle, that also infects humans. BCG vaccine is the gold standard for human bladder cancer therapy, and volatilome studies, as will be shown, will link a lipocalin from Trichosurus vulpecula called vulpeculin, to Mycobacterium bovis via the vaccine. A boundary may be crossed by gastrointestinal transmission of Mycobacterium in China, thus linking comparative genomics of the 8 coronaviruses, especially TGEV (which also links a Blumberg Foundation study) in post #518.

Mar 2021 China: Possible Gastrointestinal Transmission of Mycobacterium bovis

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