Cannabis compounds stopped COVID virus from infecting human cells in lab study

[Dont Taz Me Bro]

We're saved. Everyone just needs to go out and get high.

Cannabis compounds prevented the virus that causes COVID-19 from penetrating healthy human cells, according to a laboratory study published in the Journal of Nature Products.

Cannabis compounds stop COVID virus from infecting human cells in lab study

In the study, the compounds bound to spike proteins found on the virus and blocked a step the pathogen uses to infect people.

fortune.com

 

[TNHarley]

No wonder I havent got it yet

 

[Otis Mayfield]

Can’t access the article, but a few things make me skeptical.
They say micromolar (uM) affinity. That is usually not good enough. 10 uM is about the cutoff of what you would want in a lead compound - something to be further improved by a medicinal chemist. I suspect they were above 10 uM because if you have low uM affinity you should definitely call it out.

They used a pseudo virus but do not say which. They do not tell you which cell line or cell type they used for their disease model. This info should have gone in the abstract. It would not have taken more than a few characters.

Basically the quality of the abstract makes me doubt the quality of the research.

Also please keep in mind that this is a pseudo virus in a cell model. The graveyard of drugs is filled with filled with compounds that looked good in disease models, but did not work. Generally, the further away you are from a live virus in a live human, the less predictive the model.


-----------------


Yup. uM activity is crap. We’d discard anything that wasn’t in the nM range. And even then try and optimize.
You’d never get those kinds of concentrations in a human (well not never, but you’d be gulping down grams of the stuff if your Vd was good, tens of grams if it wasnt).


-------------------------------


In vitro, not in vivo, so its relevance to humans still has to be determined.

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants | Hacker News

news.ycombinator.com

 

[JohnDB]

Can’t access the article, but a few things make me skeptical.
They say micromolar (uM) affinity. That is usually not good enough. 10 uM is about the cutoff of what you would want in a lead compound - something to be further improved by a medicinal chemist. I suspect they were above 10 uM because if you have low uM affinity you should definitely call it out.

They used a pseudo virus but do not say which. They do not tell you which cell line or cell type they used for their disease model. This info should have gone in the abstract. It would not have taken more than a few characters.

Basically the quality of the abstract makes me doubt the quality of the research.

Also please keep in mind that this is a pseudo virus in a cell model. The graveyard of drugs is filled with filled with compounds that looked good in disease models, but did not work. Generally, the further away you are from a live virus in a live human, the less predictive the model.


-----------------


Yup. uM activity is crap. We’d discard anything that wasn’t in the nM range. And even then try and optimize.
You’d never get those kinds of concentrations in a human (well not never, but you’d be gulping down grams of the stuff if your Vd was good, tens of grams if it wasnt).


-------------------------------


In vitro, not in vivo, so its relevance to humans still has to be determined.

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants | Hacker News

news.ycombinator.com

I still believe that single malt scotch is a better antiviral than what people give it credit for. I drink it and haven't gotten Covid yet...

Of course I r had three shots of Moderna too...but I still think that the scotch has done the most good.

 

[lennypartiv]

We're saved. Everyone just needs to go out and get high.

We need to get high and hard.

---Tucker Carlson, Fox News Doctor Discuss Viagra as Possible Treatment for COVID---

Tucker Carlson, Fox News Doctor Discuss Viagra as Possible COVID Treatment

A double-vaccinated nurse in the U.K. credits an experimental treatment, including a large dose of Viagra, for saving her life after she got the disease.

www.newsweek.com

 

[Dont Taz Me Bro]

I still believe that single malt scotch is a better antiviral than what people give it credit for. I drink it and haven't gotten Covid yet...

LOL. I drink scotch and haven't had COVID either.

 

[odanny]

If cannabis wasn't made illegal by the Feds, think of all the possible benefits that it could have, medically. We need research dollars for that, and the government blocks that. How f'd up is that? We know about CBD, how about THC?

 

[BlindBoo]

Kief-o-Vax! Keep Covid away. On Sale now.

Of course you need a continual dose thought each day.....So stock up!

 

[badger2]

There's no reason to effeminize the gonads with cannabis when there are multiple alternatives that stop the commie virus in vitro. Ivermectin physically attaches to it.

 

[Oddball]

 

[JohnDB]

LOL. I drink scotch and haven't had COVID either.

See....and everyone keeps doubting me.

 

[badger2]

View attachment 586981

Yes, there is. It can't de-effeminize the gonads.

 

[petro]

So far it seems to be working for my unvaxxed ass. I will do my part and continue my experiment for the good of humanity.
You're welcome.

 

[Mr Natural]

Yet something else to thank us Boomers for.

You're welcome!

 

[Blues Man]

Ok let's just say it.

POT CURES EVERYTHING.

No wonder I'm so healthy

 

[ScorpioRising007]

We're saved. Everyone just needs to go out and get high.

More reasons Doctors and Nurses should be allowed to get high on the job.