A couple or three reasons:
1) Anything trans is associated with abuses of kids, because in the last few years, that is what trans activists have focused on. Not on avoiding job discrimination, or lobbying government and businesses to have unisex private bathrooms so trannies can safely pee. No, they are concentrating on encouraging public schools to become a pipeline for the transgenderization of children. Maybe Dylan isn't on board with that. Maybe he thinks, 'yeah, this stuff is for adult, we should not be bringing the kids into it.' If he thinks that, he should say it. If he doen't, he is part of the problem and so is Budwiser.
2) Rightly or wrongly, your typical Bud drinker probably doesn't like trannies very much and if he thinks about them, he wonders if he might ever knock back enough to be taken in and get a surprise "girl with something extra." That's if he thinks about trannies at all, which he'd likely rather not. So, he goes to buy a six pack of the King of Beers, and sees this looking at him:
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And thinks, 'who is that homely girl?' He finds out it's a boy and thinks 'are they freakin' kidding me?'
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3) Enough is enough with having wokeness pushed in front of us, whether we want it or not. The backlash is there, because that's what they wanted, and they knew how to get it.
Democrats love to "take you out of your comfort zone" and then excoriate us for being uncomfortable. It was a setup from the start, and how the AB execs fell for it will always be a mystery. Many people's comfort zones use to include Bud, and that has been taken away.