There's an interesting difference in " breakthrough reports " shown below, in that this report links heart and cancer. Well known in cancer is the endothelial-mesenchymal transition (EMT), and we perked when (six transcription factors [italics]) were found, not just one or two: Badger Herald 30 Jan 2018 Morgride Institute Fellow Shares Breakthroughs on Heart Disease "'....As a postdoc/scientist with Jamie Thomson [in blood development], I identified six transcription factors that together induce and expand progenitors of blood and vascular tissues in culture,"" Vereide said. His other discoveries include the identification of a mechanism by which the Epstein-Barr virus sustains tumor cells.,,,,As someone develops cardiovascular disease, some of their arterial endothelial cells change, Vereide said. They become mesenchymal cells, which act differently than endothelial cells. Endothelial cells are considered to be a "normal"cell type. "Mesenchymal cells can pile up on themselves, narrowing the artery, so it it is difficult for blood to flow through."Vereide said. Some of the precursor cells generated by the research team underwent an EndoMT easily, while other cells resisted the change." .... As for the immediate future, the team has two distinct goals. The first is to look more closely at the genetics of EndoMT cells and the second is to polish the cultivation of cells.