If you're trying to bring a spiritual incarnate aspect to the argument I respect that and can speak that language. Although I'm a white male I have been very steeped in eastern mysticism and spirituality. I even have an ancestor born in India. I am married to a Catholic and our exposure to Hinduism has actually been instrumental many times in bringing us closer together. It's pretty amazing really. So much so I would almost surmise that we were both Hindus in a past life!
But in this case I would have to assert that someone who is spiritually female inside who incarnates into a male body has not done so as a mistake on anyone's part. And in doing so has involuntarily answered their Dharma which automatically balances their Karma. Incarnation is a marriage of matter and spirit that can only be separated by death. There can be no X trapped inside of a Y's body. Once the spirit and the body come together to form a human being, that human being is a complete synthesis of both where they have been and where they are going. They must answer this call or they well simply make the next life even more difficult for them to reckon with.