The report from post #340 continues, as we find some resonance with asparagine and the serine-to-leucine mutations mentioned earlier:
'....Due to very limited knowledge of this novel virus, we are unable to give reasonable explanations for the significant number of amino acid substitutions between 2019-nCoV and SARS or SARS-like CoVs. For example, no amino acid substitutions were present in the receptor-binding motifs (RBMs) that directly interact with human receptor for ACE2 protein in SARS-CoV, but six mutations occurred in the other region of the RBD (receptor-binding domain). Whether these differences could affect the host tropism and transmission property of 2019-nCoV compared to SARS-CoV is worthy of future investigation.'
There is one comparison chart in this report. We first notice these:
ORF(open reading frame)14, position 99: S--->L
Nsp1 (non-structural protein 1), position 269: S--->L
These substitutions compare with those of post #313.
'....Due to very limited knowledge of this novel virus, we are unable to give reasonable explanations for the significant number of amino acid substitutions between 2019-nCoV and SARS or SARS-like CoVs. For example, no amino acid substitutions were present in the receptor-binding motifs (RBMs) that directly interact with human receptor for ACE2 protein in SARS-CoV, but six mutations occurred in the other region of the RBD (receptor-binding domain). Whether these differences could affect the host tropism and transmission property of 2019-nCoV compared to SARS-CoV is worthy of future investigation.'
There is one comparison chart in this report. We first notice these:
ORF(open reading frame)14, position 99: S--->L
Nsp1 (non-structural protein 1), position 269: S--->L
These substitutions compare with those of post #313.