As has been so often quoted on here elections have consequences so the Republicans really have two choices suck it and work with Trump or find someone to challenge him for the nomination in 2020 if he runs for reelection you think there is chaos now try and force him out and see what happens.
It would really depend. If the GOP Grew a spine and initiated the process to remove Trump through either Impeachment or the 25th Amendment, there wouldn't be an issue in getting the democrats to go along.
the thing is, the only good reason to remove Trump would be if he presented a danger to the country due to his mental instability or his general incompetence. That should go above partisanship.
You see, from the GOP Perspective, there isn't a downside. They would probably get a lot more done with Pence in the White House. It's just that their egos are too big to admit that making Trump the President was a huge mistake to start with.
Get over it.