I think Romney could lose. He's another free spender in the W, McCain mode. He contradicts himself which unlike when Democrats do it the liberal media will report. And the Left who preach tolerance will once again demonstrate they have none scaring people about a Mormon becoming President. He's getting it relatively light right now from the left and their military wing, the media, specifically because they want him nominated. They even try to help with the innuendo they are afraid most of him. Clearly they are not given how hard they are working to get him nominated.
Romney could lose. As could all the Republican candidates.
This election is going to be about economic competence, not about who is the freest, most conservative candidate. Romney has a huge amount of credibility on the economy. Perry does as well, given that Texas has done well over the past decade. But Perry sort of reminds one of a Texan John Kerry. Ron Paul is certainly unique but he doesn't look nor sound the part, and won't get the nomination.