I think the Pfizer vaccine and the Moderna vaccine will prove to be safest and most effective . Since they are mRNA vaccinates tweaking them for protection of new variants should be very easy. Moderna said they could have a new vaccine ready by the new year. The downside is that these vaccines require two doses and very low temperature storage.Which is why I am waiting for the traditional vaccines. A few are being made by some Indian companies, and are going through the process for FDA approval. The FDA is dragging it’s feet on them though, since the FDA is in bed with Pfizer and Moderna.
All the vaccines being used are based on either new technologies or have been been complete reworked for Covid. ZyCoV-D, the new vaccine from India is the first DNA vaccine to be given two humans. Of 6 the vaccines in use today, 4 of them create the spike protein. There is nothing really traditional about any of these vaccines. They all end up doing the same thing, they just do it a bit differently. Traditional viral vaccines used live or attenuated viruses. None of these do.