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Engineering Vaccines for Newborns | News | Northwestern Engineering
Engineering Vaccines for Newborns
Nano-carrier system makes vaccines more effective for newborns
Apr 11, 2017 // Amanda Morris
Called the “window of vulnerability,” the first year of a newborn baby’s life is when they are highly susceptible to infectious diseases. This window could narrow or even close completely, if it were possible to vaccinate infants immediately after birth. Instead, two million babies worldwide die each year from infectious diseases before they turn six months old.
Evan Scott“The time of birth is the most reliable point of care for newborns and an efficient opportunity for immunization,” said Northwestern Engineering’s Evan Scott. “The majority of vaccines simply aren’t effective for infants because their immune systems haven’t sufficiently developed.”
Inspired by the BCG (Bacillus Calmette-Guérin) vaccine for tuberculosis, which does work safely and reliably in newborns, Scott and his collaborators are using nanotechnology to make more vaccines that can be administered successfully at the time of birth. They have employed a small molecule that, when delivered into the body via nanoparticles, mimics the type of immune response induced by BCG.
Supported by the National Institutes of Health, National Science Foundation, and Bill and Melinda Gates Foundation, the research was published recently in the Journal of Allergy and Clinical Immunology. Ofer Levy, an infectious diseases specialist at Boston Children’s Hospital, and Jeffrey Hubbell, a biomedical engineer at the University of Chicago, led the study. Scott, assistant professor of biomedical engineering in Northwestern’s McCormick School of Engineering,.......more at link