I have always liked a bigger chunk of lead. Not so long ago the .380 was considered inadequate. But, from what I have read and seen online, the newer .380 ammo is much better and that it is now a decent defensive round. Probably about the bottom end of what I would say was a defensive round.
But then, whatever you have at hand is better than nothing. I can think of a lot of times when, if I had been attacked, I would have had to defend myself with a Ruger 10/22. Hardly optimal.