This is the general idea of the modern competitor to the information theoretic approach.
www.nature.com
Path integrals are a lot like Feynman diagrams in physics, they seek to describe ensemble probabilities using "the sum of all possible paths".
In this approach there is also no direct quantitative bridge between what is predicted and what is observed - and in biology as in physics, the concept of "all" possible pathways is ridiculous to begin with, but in biology as in physics, the actuals seem to line up pretty well with the observables after 2 or 3 "renormalizations".

Path probability selection in nature and path integral - Scientific Reports
Understanding of any biological evolutions, such as speciation, adaptation behavior and biodiversity pattern, is based on a fundamental concept of fitness, in which natural selection implies the improvement and progress of fitness in either direct/indirect benefit or genetic transmission to the...

Path integrals are a lot like Feynman diagrams in physics, they seek to describe ensemble probabilities using "the sum of all possible paths".
In this approach there is also no direct quantitative bridge between what is predicted and what is observed - and in biology as in physics, the concept of "all" possible pathways is ridiculous to begin with, but in biology as in physics, the actuals seem to line up pretty well with the observables after 2 or 3 "renormalizations".