Evolution of the Saxophone

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Both sequences from Chinese krait, Bungarus, are from the Animal Toxinological Department, Kunming Institute of Zoology, Kunming, Yunnan, China.

 

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COVID-19 uses ACE2 receptor.

Wuhan Institute of Virology, 22 Nov 2013, Rhinolophus sinicus ACE2, isolate RS-3357

M S G S S W L L L S L V A V T T A Q S T T E D E A K M F L D K....

Apparently, there is no ACE2 sequence for Rhinolophus affinis.

 

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Pangolin Hep A receptor was derived from an automated computational analysis, as is this pangolin ACE2 sequence, which can be compared with bat ACE2:

M S G S S W L L L S L V A V T A A Q S T S D E E A K T F L E K

These sequences can be played and chords added according to the chart in post #2.

 

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Here is a segment from the complete genome of COVID-19 that readers can explore for interesting musical regions:

COVID-19
Wuhan seafood market pneumonia virus isolate 2019-nCoV_HKU-SZ-002a_202 - Nucleotide - NCBI

 

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Codon usage and/or bias can also be studied in post #184.

 

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The reason being that Yunnan bat SARS-like virus is closest to human sequence (96.2%), though Rhinolophus affinis ACE2 has apparently not been sequenced.

Rhinolophus affinis ACE2
Identification of Diverse Bat Alphacoronaviruses and Betacoronaviruses in China Provides New Insights Into the Evolution and Origin of Coronavirus-... - PubMed - NCBI
'....Another alpha-CoV, alpha-YN2018 from Rhinolophus affinis in Yunnan, suggested that this alpha-CoV lineage had multiple host origins, and alpha-YN2018 had recombined with CoVs of other bat species over time....confirmed that ACE2-usable SARSr-CovS were continuously circulating in Rhinolophus in Yunnan.'

 

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Note that the authors of the above study (post #186) includes Eco Health Alliance, New York.

 

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Pangolin ACE2 (post #183) is the most timely (and specific vaccine-related sequence to play [insert your own chords]), if the Chinese are correct:

URL will function if typed in spacebar:
gzscbm.com/web/technique/792.html
'....Researchers from Huazhong Agricultural University analyzed and compared the entire genome sequence....2019-nCoV and found that it is highly similar to the known Yunnan bat Beta-Coronavirus (96.1%)....On 7 Feb, South China Agricultural University and other units conducted metagenomic analysis of wild animal samples and identified the genetic sequence of the coronavirus strain isolated from pangolins as high as 99% with 2019-nCoV, indicating that pangolins are the potential intermediate host.'

 

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Pangolin Music for Composers
(See post #2)
Of course, the composer may add chords anywhere they wish to the melody line:

No items found - Nucleotide - NCBI

PREDICTED: Manis javanica influenza virus NS1A binding protein (IVNS1A - Nucleotide - NCBI

PREDICTED: Manis javanica feline leukemia virus subgroup C cellular re - Nucleotide - NCBI

 

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Manis pentadactyla human immunodeficiency virus type I enhancer bindin - Nucleotide - NCBI

 

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In post #191, one may wish to experiment with ominous-sounding chords placed especially at or near to the two double leucines and/or the two double serines in the sequence.

 

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An apparent insertion in the COVID-19 virus sequence (USMB Snake Meat thread, post #419: " On the Origins of the 2019-NCoV Virus, Wuhan, China") must be translated in order to turn it into music. This seems to be a key sequence, that begins....L S F T F N S G L V L.... (see post #2, this thread)

Readers can translate the entire sequence by using the translation app: www. search for "Translate Nucleotide Sequence Into Protein Sequence." Because of mutations in Orf8 of the virus, as well as codon usage, we are particularly interested in serines and leucines.

 

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A bit of the pangolin ACE2 melody is at post #183, and the music could accompany this footage:

World Pangolin Day, February 15

 

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The COVID-19/pangolin study is not yet published.
Did pangolins spread the China coronavirus to people?
(URL will function if typed in spacebar)
'...."I look forward to the published reports and data." '

The FOXP2 gene links to dyslexia (previous posts). The FoxP3 gene links to pangolins. We have both FoxP2 and FoxP3 human sequences on the electric sax workbench, which sequences we will compare tonight. Meanwhile, for possible vaccine studies, we compare pangolin BATF and human BATF:

BATF (basic leucine zipper AFT-like transcription factor), Homo sapiens
(/ @ every ten aminos)

M P H S S D S S D S / S F S R S P P P G K / Q D S S D D V R R V / Q R R E K N R I A A / Q K S R Q R Q T Q K / A D T L H L E S E D / L E K Q N A A L R K / E I K Q L T E E L K / Y F T S V L S S H E / P L C S V L T S S T / P S P P E V V Y S T / H A F H Q P H V S S / P R F Q P

BATF Manis

M P H S S D S S D S / S F S R S P P S G K / Q D S S D D V R K V / Q R R E K N R I A A / Q K S R Q R Q T Q K / A D T L H L E S E D / L E K Q N A A L R K / E I K Q L T E E M K / Y F T S V LS S H E / P L C S V L T S S T / P S P P E V V Y S T / H A F H Q P H V S S / P R F Q P

There are 5 differences, which will change the melody and perhaps the composer-chosen chords. Keeping in mind that COVID-19 Orf8 position 84 is leucine, while the closest bat virus at position 84 is a serine:

BATF Comparisons

1. @ position 18, human is proline, pangolin is serine.

2. @ position 29, human is arginine, pangolin is lysine.

3. @ position 79, human is leucine, pangolin is methionine.

4. @ position 86, human is asparagine, pangolin is serine.

5. @ position 110, human is alanine, pangolin is threonine.

One of the first studies to link FOXP2 with dyslexia was from (2001) Wellcome Trust, Oxford, UK
A forkhead-domain gene is mutated in a severe speech and language disorder. - PubMed - NCBI

One current (Jan 2020) BATF link to FOXP3 is from Heidelberg/Vienna
Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. - PubMed - NCBI
'....fatal multiorgan autoinflammatory destruction....'

 

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There is a cloaked similarity between HIV-1 virus and SARS-CoV, and an antiviral sequence against both viruses can be turned into a melody (post # 2, this thread) for further study:

Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy
'....I S G I N A S V V N I Q K E I D R L N E V A K K N L E S L I D L Q E L ....'

 

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Why are blacks in Mississippi better readers than blacks in Wisconsin? The video is well worth the 30 minutes because it involves all states and beyond:

12 Feb 2020 News Conference: Wisconsin Call to Action for Reading Excellence
(URL as found)
wiseye.org/2020/02/12/news-conference-wisconsin-call-to-action-for-reading-excellence/

(First Alternate URL)
News Conference: Wisconsin Call to Action for Reading Excellence - WisconsinEye

(Second Alternate URL)
News Conference: Wisconsin Call to Action for Reading Excellence - WisconsinEye

@ timepoint 3:33 'We have the largest black-white achievement gap of any state, 39 points....Wisconsin's white students rank 34th among white students in the nation

@ 6:13 Dr. Mark Seidenberg, Language at the Speed of Sight

an especially informative presentation:
@ 13:10 Donna Hejtmanek....Facebook Science of Reading: What I Should Have Learned in College

@ 20:15 "I wish I would have had this knowledge 30 years ago"

@ 21:18 'shall be based on the International Dyslexia Association knowledge and practice standards for teachers of reading....'

 

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Here is the complete genome of COVID-19. One can see the leucine (that was a serine in the bat virus) at position 84 of Orf8. When using synthesizer switches with extended wires to pre-set a certain amino acid sequence, only about 6 or so un-named switches need be used for repeated notes (ex., a repeated serine is attached to a previous one via the un-named auxiliary switch[can be temporarily marked]), because the tape-recorder can be stopped and a new part of the sequence can be pre-set (re-arranged from the previous arrangement). At any rate, pre-setting the notes means that any part of a sequence can first be heard, in the search for interesting melodies to go with chosen chords. COVID-19 has many possibilities:

Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete geno - Nucleotide - NCBI

 

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At last, some music is emerging from the Hot Zone:

Wuhan Song, Let Us Meet in Spring"
(URL is posted as found)
曾錚 Jennifer Zeng on Twitter

 

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The latest report from Wuhan, San Diego and Los Alamos (Journal of Medical Virology) implicates the painted turtle as intermediate host of COVID-19. Here are two timely amino acid sequences for musical investigation:

Chrysemys picta bellii Influenza Binding Protein
PREDICTED: Chrysemys picta bellii influenza virus NS1A binding protein - Nucleotide - NCBI

C. picta bellii Feline Leukemia Virus
PREDICTED: Chrysemys picta bellii feline leukemia virus subgroup C cel - Nucleotide - NCBI

 

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We are very pleased to see a gadget that has the potential to be used on saxophone and other woodwind instruments, although there's a ridiculous URL to transcribe to see it. Best search www. for 'Ezfret Beginner Guitar Attachment Ebay." This unit has the potential to allow woodwind players to produce chords with either the left or right hand, while using the other to play melodies.Attaching two to a flute, for example, would be most versatile in performance. For our current Mendini sax-Hamzer electronic piano setup, we will use right hand chord production. The cantilevered positioning of the Ezfret also meshes nicely with the ergonomics of our previously proposed performance stick, also applicable to the body of a digeridoo. Unfortunately, the Ezfret does not seem adaptable to the pre-setting of amino acid sequences for preliminary audition (previous posts).